Literature DB >> 26926048

Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V.

Saikat Roy1, N Rajesh Goud1, Adam J Matzger2.   

Abstract

This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.

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Year:  2016        PMID： 26926048      PMCID： PMC4964875          DOI： 10.1039/c6cc00959j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  21 in total

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Authors:  Shuang Chen; Ilia A Guzei; Lian Yu
Journal:  J Am Chem Soc       Date:  2005-07-13       Impact factor: 15.419

2.  A strategy for predicting the crystal structures of flexible molecules: the polymorphism of phenobarbital.

Authors:  G M Day; W D S Motherwell; W Jones
Journal:  Phys Chem Chem Phys       Date:  2007-01-24       Impact factor: 3.676

3.  Studying microstructure in molecular crystals with nanoindentation: intergrowth polymorphism in felodipine.

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Journal:  Angew Chem Int Ed Engl       Date:  2014-09-26       Impact factor: 15.336

4.  Infrared identification of barbiturates with particular reference to the occurrence of polymorphism.

Authors:  R J Mesley; R L Clements
Journal:  J Pharm Pharmacol       Date:  1968-05       Impact factor: 3.765

5.  Crystalline polymorph selection and discovery with polymer heteronuclei.

Authors:  Christopher P Price; Adam L Grzesiak; Adam J Matzger
Journal:  J Am Chem Soc       Date:  2005-04-20       Impact factor: 15.419

6.  Conformational polymorphism in organic crystals.

Authors:  Ashwini Nangia
Journal:  Acc Chem Res       Date:  2008-03-19       Impact factor: 22.384

7.  Conformational polymorphism of tolbutamide: A structural, spectroscopic, and thermodynamic characterization of Burger's forms I-IV.

Authors:  Satyanarayana Thirunahari; Srinivasulu Aitipamula; Pui Shan Chow; Reginald B H Tan
Journal:  J Pharm Sci       Date:  2010-07       Impact factor: 3.534

8.  New form discovery for the analgesics flurbiprofen and sulindac facilitated by polymer-induced heteronucleation.

Authors:  Adam L Grzesiak; Adam J Matzger
Journal:  J Pharm Sci       Date:  2007-11       Impact factor: 3.534

9.  Comparison of the four anhydrous polymorphs of carbamazepine and the crystal structure of form I.

Authors:  Adam L Grzesiak; Meidong Lang; Kibum Kim; Adam J Matzger
Journal:  J Pharm Sci       Date:  2003-11       Impact factor: 3.534

10.  A new gamma-polymorph of chlorpropamide: 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide.

Authors:  Tatiana N Drebushchak; Nikita V Chukanov; Elena V Boldyreva
Journal:  Acta Crystallogr C       Date:  2007-05-11       Impact factor: 1.172
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  2 in total

1.  Enhanced NMR Discrimination of Pharmaceutically Relevant Molecular Crystal Forms through Fragment-Based Ab Initio Chemical Shift Predictions.

Authors:  Joshua D Hartman; Graeme M Day; Gregory J O Beran
Journal:  Cryst Growth Des       Date:  2016-10-04       Impact factor: 4.076

2.  Survey and analysis of crystal polymorphism in organic structures.

Authors:  Kortney Kersten; Ramanpreet Kaur; Adam Matzger
Journal:  IUCrJ       Date:  2018-01-25       Impact factor: 4.769
  2 in total

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