Literature DB >> 25264144

Studying microstructure in molecular crystals with nanoindentation: intergrowth polymorphism in felodipine.

Manish Kumar Mishra1, Gautam R Desiraju, Upadrasta Ramamurty, Andrew D Bond.   

Abstract

Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  X-ray diffraction; crystal engineering; microstructure; nanoindentation; polymorphism

Mesh：

Substances：

Year:  2014        PMID： 25264144     DOI： 10.1002/anie.201406898

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  5 in total

1.  Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V.

Authors:  Saikat Roy; N Rajesh Goud; Adam J Matzger
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

2.  Uniaxial Negative Thermal Expansion and Mechanical Properties of a Zinc-Formate Framework.

Authors:  Hongqiang Gao; Wenjuan Wei; Yizhang Li; Rong Wu; Guoqiang Feng; Wei Li
Journal:  Materials (Basel)       Date:  2017-02-10       Impact factor: 3.623

3.  Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties.

Authors:  M B Avinash; Devaraj Raut; Manish Kumar Mishra; Upadrasta Ramamurty; T Govindaraju
Journal:  Sci Rep       Date:  2015-11-03       Impact factor: 4.379

4.  Crystal chemistry and photomechanical behavior of 3,4-dimethoxycinnamic acid: correlation between maximum yield in the solid-state topochemical reaction and cooperative molecular motion.

Authors:  Manish Kumar Mishra; Arijit Mukherjee; Upadrasta Ramamurty; Gautam R Desiraju
Journal:  IUCrJ       Date:  2015-10-16       Impact factor: 4.769

Review 5.  Influences of Crystal Anisotropy in Pharmaceutical Process Development.

Authors:  Eftychios Hadjittofis; Mark Antonin Isbell; Vikram Karde; Sophia Varghese; Chinmay Ghoroi; Jerry Y Y Heng
Journal:  Pharm Res       Date:  2018-03-19       Impact factor: 4.200
  5 in total

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