OBJECTIVES: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). METHODS: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. RESULTS: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA. CONCLUSIONS: In RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values remain unaffected, suggesting that T1-shortening in these patients is related to the amount of Gadolinium given. KEY POINTS: • In multiple sclerosis, previous Gadolinium administrations correlate with dentate nuclei T1 relaxometry. • Such correlation is linked to linear Gadolinium chelates and unrelated to disease duration or severity. • Dentate nuclei T2* relaxometry is age-related and independent of previous Gadolinium administrations. • Changes in dentate nuclei T1 relaxometry are not determined by iron accumulation. • MR relaxometry can quantitatively assess Gadolinium accumulation in dentate nuclei.
OBJECTIVES: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). METHODS: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. RESULTS: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA. CONCLUSIONS: In RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values remain unaffected, suggesting that T1-shortening in these patients is related to the amount of Gadolinium given. KEY POINTS: • In multiple sclerosis, previous Gadolinium administrations correlate with dentate nuclei T1 relaxometry. • Such correlation is linked to linear Gadolinium chelates and unrelated to disease duration or severity. • Dentate nuclei T2* relaxometry is age-related and independent of previous Gadolinium administrations. • Changes in dentate nuclei T1 relaxometry are not determined by iron accumulation. • MR relaxometry can quantitatively assess Gadolinium accumulation in dentate nuclei.
Authors: Christian Langkammer; Nikolaus Krebs; Walter Goessler; Eva Scheurer; Franz Ebner; Kathrin Yen; Franz Fazekas; Stefan Ropele Journal: Radiology Date: 2010-09-15 Impact factor: 11.105
Authors: Alexander Radbruch; Lukas D Weberling; Pascal J Kieslich; Oliver Eidel; Sina Burth; Philipp Kickingereder; Sabine Heiland; Wolfgang Wick; Heinz-Peter Schlemmer; Martin Bendszus Journal: Radiology Date: 2015-04-06 Impact factor: 11.105
Authors: Stefan Ropele; Iris D Kilsdonk; Mike P Wattjes; Christian Langkammer; Wolter L de Graaf; Jette L Frederiksen; Henrik B Larsson; Marios Yiannakas; Claudia Am Wheeler-Kingshott; Christian Enzinger; Michael Khalil; Maria A Rocca; Till Sprenger; Michael Amann; Ludwig Kappos; Massimo Filippi; Alex Rovira; Olga Ciccarelli; Frederik Barkhof; Franz Fazekas Journal: Mult Scler Date: 2014-04-30 Impact factor: 6.312
Authors: S Swaminathan; W A High; J Ranville; T D Horn; K Hiatt; M Thomas; H H Brown; S V Shah Journal: Kidney Int Date: 2008-04-09 Impact factor: 10.612
Authors: Alexander Radbruch; Lukas D Weberling; Pascal J Kieslich; Johanna Hepp; Philipp Kickingereder; Wolfgang Wick; Heinz-Peter Schlemmer; Martin Bendszus Journal: Invest Radiol Date: 2015-12 Impact factor: 6.016
Authors: G Pontillo; S Cocozza; R Lanzillo; C Russo; M D Stasi; C Paolella; E A Vola; C Criscuolo; P Borrelli; G Palma; E Tedeschi; V B Morra; A Elefante; A Brunetti Journal: AJNR Am J Neuroradiol Date: 2018-12-20 Impact factor: 3.825
Authors: Carlo C Quattrocchi; Joana Ramalho; Aart J van der Molen; Àlex Rovira; Alexander Radbruch Journal: Eur Radiol Date: 2018-11-09 Impact factor: 5.315
Authors: G Barisano; B Bigjahan; S Metting; S Cen; L Amezcua; A Lerner; A W Toga; M Law Journal: AJNR Am J Neuroradiol Date: 2019-07-25 Impact factor: 3.825