BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping. SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume. RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load. CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.
BACKGROUND:Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping. SUBJECTS AND METHODS: Ninety-seven MSpatients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume. RESULTS: Compared to controls, R2* was increased in all deep GM regions of MSpatients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load. CONCLUSION:Iron accumulation in deep GM of MSpatients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.
Authors: Christian Enzinger; Frederik Barkhof; Olga Ciccarelli; Massimo Filippi; Ludwig Kappos; Maria A Rocca; Stefan Ropele; Àlex Rovira; Torben Schneider; Nicola de Stefano; Hugo Vrenken; Claudia Wheeler-Kingshott; Jens Wuerfel; Franz Fazekas Journal: Nat Rev Neurol Date: 2015-11-03 Impact factor: 42.937
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Authors: A Burgetova; P Dusek; M Vaneckova; D Horakova; C Langkammer; J Krasensky; L Sobisek; P Matras; M Masek; Z Seidl Journal: AJNR Am J Neuroradiol Date: 2017-04-27 Impact factor: 3.825
Authors: Thomas Martin Doring; Vanessa Granado; Fernanda Rueda; Andreas Deistung; Juergen R Reichenbach; Gustavo Tukamoto; Emerson Leandro Gasparetto; Ferdinand Schweser Journal: PLoS One Date: 2016-05-12 Impact factor: 3.240
Authors: Eva Baranovicova; Ema Kantorova; Dagmar Kalenska; Lucia Lichardusova; Michal Bittsan-Sky; Dusan Dobrota Journal: J Biomed Res Date: 2017-07-13
Authors: Peter Kelemen; Jamila Alaoui; Dominik Sieron; Andrew Chan; Christian P Kamm; Mirjam R Heldner; Jan Gralla; Roland Wiest; Rajeev K Verma Journal: Sci Rep Date: 2018-11-15 Impact factor: 4.379
Authors: Faiez Al Nimer; Christina Elliott; Joakim Bergman; Mohsen Khademi; Ann M Dring; Shahin Aeinehband; Tommy Bergenheim; Jeppe Romme Christensen; Finn Sellebjerg; Anders Svenningsson; Christopher Linington; Tomas Olsson; Fredrik Piehl Journal: Neurol Neuroimmunol Neuroinflamm Date: 2016-01-07