Andrea Lazik-Palm1, Oliver Kraff2, Christina Geis3, Sören Johst2, Juliane Goebel3, Mark E Ladd3,2,4, Harald H Quick2,5, Jens M Theysohn3. 1. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany. andrea.lazik@uk-essen.de. 2. Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany. 3. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany. 4. Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 5. High-Field and Hybrid MR Imaging, University Hospital Essen, Essen, Germany.
Abstract
OBJECTIVES: To investigate the influence of intravenous gadolinium on cartilage T2 and T2* relaxation times and on morphological image quality at 7-T hip MRI. METHODS: Hips of 11 healthy volunteers were examined at 7 T. Multi-echo sequences for T2 and T2* mapping, 3D T1 volumetric interpolated breath-hold examination (VIBE) and double-echo steady-state (DESS) sequences were acquired before and after intravenous application of gadolinium according to a delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) protocol. Cartilage relaxation times were measured in both scans. Morphological sequences were assessed quantitatively using contrast ratios and qualitatively using a 4-point Likert scale. Student's t-test, Pearson's correlation (ρ) and Wilcoxon sign-rank test were used for statistical comparisons. RESULTS: Pre- and post-contrast T2 and T2* values were highly correlated (T2: acetabular: ρ = 0.76, femoral: ρ = 0.77; T2*: acetabular: ρ = 0.80, femoral: ρ = 0.72). Gadolinium enhanced contrasts between cartilage and joint fluid in DESS and T1 VIBE according to the qualitative (p = 0.01) and quantitative (p < 0.001) analysis. The delineation of acetabular and femoral cartilage and the labrum predominantly improved with gadolinium. CONCLUSIONS: Gadolinium showed no relevant influence on T2 or T2* relaxation times and improved morphological image quality at 7 T. Therefore, morphological and quantitative sequences including dGEMRIC can be conducted in a one-stop-shop examination. KEY POINTS: • Hip cartilage T2 values correlate highly before and after gadolinium at 7 T • Hip cartilage T2* values correlate highly before and after enhancement at 7 T • Morphological hip cartilage imaging benefits from intravenous gadolinium at 7 T • The delineation of acetabular and femoral cartilage can be improved by gadolinium • Morphological and quantitative sequences including dGEMRIC can be combined as a one-stop-shop examination.
OBJECTIVES: To investigate the influence of intravenous gadolinium on cartilage T2 and T2* relaxation times and on morphological image quality at 7-T hip MRI. METHODS: Hips of 11 healthy volunteers were examined at 7 T. Multi-echo sequences for T2 and T2* mapping, 3D T1 volumetric interpolated breath-hold examination (VIBE) and double-echo steady-state (DESS) sequences were acquired before and after intravenous application of gadolinium according to a delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) protocol. Cartilage relaxation times were measured in both scans. Morphological sequences were assessed quantitatively using contrast ratios and qualitatively using a 4-point Likert scale. Student's t-test, Pearson's correlation (ρ) and Wilcoxon sign-rank test were used for statistical comparisons. RESULTS: Pre- and post-contrast T2 and T2* values were highly correlated (T2: acetabular: ρ = 0.76, femoral: ρ = 0.77; T2*: acetabular: ρ = 0.80, femoral: ρ = 0.72). Gadolinium enhanced contrasts between cartilage and joint fluid in DESS and T1 VIBE according to the qualitative (p = 0.01) and quantitative (p < 0.001) analysis. The delineation of acetabular and femoral cartilage and the labrum predominantly improved with gadolinium. CONCLUSIONS:Gadolinium showed no relevant influence on T2 or T2* relaxation times and improved morphological image quality at 7 T. Therefore, morphological and quantitative sequences including dGEMRIC can be conducted in a one-stop-shop examination. KEY POINTS: • Hip cartilage T2 values correlate highly before and after gadolinium at 7 T • Hip cartilage T2* values correlate highly before and after enhancement at 7 T • Morphological hip cartilage imaging benefits from intravenous gadolinium at 7 T • The delineation of acetabular and femoral cartilage can be improved by gadolinium • Morphological and quantitative sequences including dGEMRIC can be combined as a one-stop-shop examination.
Entities:
Keywords:
Hip cartilage; T2 mapping; T2* mapping; Ultra-high-field MRI; dGEMRIC
Authors: J M Theysohn; O Kraff; S Orzada; N Theysohn; T Classen; S Landgraeber; M E Ladd; T C Lauenstein Journal: Skeletal Radiol Date: 2013-08-18 Impact factor: 2.199
Authors: Iris M Noebauer-Huhmann; Pavol Szomolanyi; Vladimír Juras; Oliver Kraff; Mark E Ladd; Siegfried Trattnig Journal: Invest Radiol Date: 2010-09 Impact factor: 6.016
Authors: José G Raya; Eike Dettmann; Mike Notohamiprodjo; Svetlana Krasnokutsky; Steven Abramson; Christian Glaser Journal: Eur Radiol Date: 2014-05-10 Impact factor: 5.315
Authors: Jatta E Kurkijärvi; Mikko J Nissi; Jarno Rieppo; Juha Töyräs; Ilkka Kiviranta; Miika T Nieminen; Jukka S Jurvelin Journal: Magn Reson Imaging Date: 2007-12-26 Impact factor: 2.546
Authors: Emily S Mills; Jacob A Becerra; Katie Yensen; Ioanna K Bolia; Edward C Shontz; Kareem J Kebaish; Andrew Dobitsch; Laith K Hasan; Aryan Haratian; Charlton D Ong; Jordan Gross; Frank A Petrigliano; Alexander E Weber Journal: Orthop Res Rev Date: 2022-09-14
Authors: Noam Ben-Eliezer; José G Raya; James S Babb; Thomas Youm; Daniel K Sodickson; Riccardo Lattanzi Journal: Cartilage Date: 2019-08-27 Impact factor: 3.117