Literature DB >> 2682630

Regulation of a bifunctional mRNA results in synthesis of secreted and nuclear probasin.

A M Spence1, P C Sheppard, J R Davie, Y Matuo, N Nishi, W L McKeehan, J G Dodd, R J Matusik.   

Abstract

Probasin, a rat prostatic protein, is statistically related to members of a protein family that includes serum, cellular, and nuclear proteins. In vivo, probasin appears both in the secretions and in the nucleus of prostatic epithelial cells. Using primer extension and S1 nuclease protection assays we detected only one probasin mRNA. Thus, the localization of this protein to two separate cellular regions must be encoded by this one mRNA. Furthermore, in vitro translation of synthetic probasin mRNA demonstrated that a protein containing a signal peptide and a protein lacking a signal peptide were synthesized by initiation at different AUG codons. These data are consistent with a mechanism of translational regulation of a eukaryotic bifunctional mRNA.

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Year:  1989        PMID： 2682630      PMCID： PMC298167          DOI： 10.1073/pnas.86.20.7843

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Sequences and properties of two ribosome binding sites from the small size class of reovirus messenger RNA.

Authors:  M Kozak; A J Shatkin
Journal:  J Biol Chem       Date:  1977-10-10       Impact factor: 5.157

2.  Post-castration rebound of an androgen regulated prostatic gene.

Authors:  R Sweetland; P C Sheppard; J G Dodd; R J Matusik
Journal:  Mol Cell Biochem       Date:  1988-11       Impact factor: 3.396

3.  The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event.

Authors:  O M Conneely; D M Kettelberger; M J Tsai; W T Schrader; B W O'Malley
Journal:  J Biol Chem       Date:  1989-08-25       Impact factor: 5.157

4.  The amino acid sequence of goat beta-lactoglobulin.

Authors:  G Préaux; G Braunitzer; B Schrank; A Stangl
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1979-11

5.  Gene-sized pieces produced by digestion of linear duplex DNA with mung bean nuclease.

Authors:  W D Kroeker; D Kowalski
Journal:  Biochemistry       Date:  1978-08-08       Impact factor: 3.162

6.  Exonuclease III of Escherichia coli K-12, an AP endonuclease.

Authors:  S G Rogers; B Weiss
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

7.  Influence of mRNA secondary structure on binding and migration of 40S ribosomal subunits.

Authors:  M Kozak
Journal:  Cell       Date:  1980-01       Impact factor: 41.582

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Molecular cloning of odorant-binding protein: member of a ligand carrier family.

Authors:  J Pevsner; R R Reed; P G Feinstein; S H Snyder
Journal:  Science       Date:  1988-07-15       Impact factor: 47.728

Review 10.  A profusion of controls.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1988-07       Impact factor: 10.539
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  18 in total

1.  Relationship between utilization of dual translational initiation signals and protein processing in Streptomyces.

Authors:  S Taguchi; K Nishiyama; I Kumagai; H Momose; K Miura
Journal:  Mol Gen Genet       Date:  1991-04

2.  Structural organization of the gene for prostaglandin D synthase in the rat brain.

Authors:  M Igarashi; A Nagata; H Toh; Y Urade; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

Review 3.  Mouse models of prostate cancer: picking the best model for the question.

Authors:  Magdalena M Grabowska; David J DeGraff; Xiuping Yu; Ren Jie Jin; Zhenbang Chen; Alexander D Borowsky; Robert J Matusik
Journal:  Cancer Metastasis Rev       Date:  2014-09       Impact factor: 9.264

4.  Existence of two forms of rat liver arginyl-tRNA synthetase suggests channeling of aminoacyl-tRNA for protein synthesis.

Authors:  P Sivaram; M P Deutscher
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

Review 5.  The lipocalin protein family: structure and function.

Authors:  D R Flower
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

6.  Structural and functional characterization of rev-like transcripts of equine infectious anemia virus.

Authors:  R Rosin-Arbesfeld; M Rivlin; S Noiman; P Mashiah; A Yaniv; T Miki; S R Tronick; A Gazit
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

7.  A glycoprotein modified with terminal N-acetylglucosamine and localized at the nuclear rim shows sequence similarity to aldose-1-epimerases.

Authors:  A Heese-Peck; N V Raikhel
Journal:  Plant Cell       Date:  1998-04       Impact factor: 11.277

8.  Two species of Rev proteins, with distinct N termini, are expressed by caprine arthritis encephalitis virus.

Authors:  A Gazit; P Mashiah; H Kalinski; A Gast; R Rosin-Abersfeld; S R Tronick; A Yaniv
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

9.  Co-localisation of autoimmune antibodies specific for double stranded DNA with procorticotrophin-releasing hormone within the nucleus of stably transfected CHO-K1 cells.

Authors:  M G Castro; E Morrison; P Tomasec; E A Linton; P R Lowenstein
Journal:  Cell Tissue Res       Date:  1995-12       Impact factor: 5.249

10.  mRNA leader length and initiation codon context determine alternative AUG selection for the yeast gene MOD5.

Authors:  L B Slusher; E C Gillman; N C Martin; A K Hopper
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205
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