| Literature DB >> 2760059 |
O M Conneely1, D M Kettelberger, M J Tsai, W T Schrader, B W O'Malley.
Abstract
The chicken progesterone receptor A and B proteins differ by an additional 128 amino acids located at the N terminus of the B protein. Using site-directed mutagenesis, we demonstrate that these two proteins arise by alternate initiation of translation from two in-phase AUG codons located on a single mRNA transcript. Both proteins are transcriptionally active in terms of their ability to activate a progesterone-responsive target gene. These results suggest a functional significance for evolutionary conservation of two forms of this steroid receptor.Entities:
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Year: 1989 PMID： 2760059
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157