I A Grafe1, G Nöldge2, C Weiss3, M Libicher2, M Baier4, P Nawroth1, P-J Meeder4, B Wiedenhöfer4, C Kasperk5. 1. Division of Osteology, Department of Medicine I and Clinical Chemistry, Ruprecht-Karls-University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. 2. Department of Radiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany. 3. Department of Biostatistics, Faculty of Clinical Medicine Mannheim, University of Heidelberg, INF 410, 69120, Heidelberg, Germany. 4. Department of Orthopedic Surgery, University of Heidelberg, INF 410, 69120, Heidelberg, Germany. 5. Division of Osteology, Department of Medicine I and Clinical Chemistry, Ruprecht-Karls-University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Christian.Kasperk@med.uni-heidelberg.de.
Abstract
BACKGROUND: It is unclear if an MR-detectable bone marrow edema is a prerequisite for pain reduction and morphological correction by kyphoplasty. This comparative trial evaluates clinical and radiomorphological outcomes after kyphoplasty of painful osteoporotic vertebral fractures with and without preoperative MR-detectable bone marrow edema for 1 year of follow-up. METHODS: Preoperative MR-images of 45 patients who received kyphoplasty for treatment of painful osteoporotic vertebral fractures were evaluated with regard to presence (n = 27) or absence (n = 18) of vertebral bone marrow edema. Pain scores (VAS 0-100) and radiomorphological measures (midline vertebral height, kyphosis angle) were analysed at baseline, postoperatively and after 12 months. RESULTS: In the "bone edema" group, pain scores improved from 72.7 to 46.8 (postoperative) and 48.0 (12 months, P < 0.001, both). In the group without preoperative bone edema, pain score improved from 70.7 to 60.3 (postoperative, P = 0.013) and to 50.1 (12 months, P = 0.001). Pain scores of both groups were significantly different directly postoperative (P = 0.026), but not after 12 months (P = 0.714). Vertebral height restoration was slightly greater in the "bone edema" group (10.2% vs. 7.8%, P = 0.289). Correction of the kyphosis angle was greater in the "bone edema" group (P = 0.014) compared to the "no bone edema" group (P = 0.838). CONCLUSION: A preoperative MR-detectable vertebral bone marrow edema predicts a better short-term outcome after kyphoplasty, but is not a prerequisite for long-term pain reduction in patients with old, chronically painful osteoporotic vertebral fractures.
BACKGROUND: It is unclear if an MR-detectable bone marrow edema is a prerequisite for pain reduction and morphological correction by kyphoplasty. This comparative trial evaluates clinical and radiomorphological outcomes after kyphoplasty of painful osteoporotic vertebral fractures with and without preoperative MR-detectable bone marrow edema for 1 year of follow-up. METHODS: Preoperative MR-images of 45 patients who received kyphoplasty for treatment of painful osteoporotic vertebral fractures were evaluated with regard to presence (n = 27) or absence (n = 18) of vertebral bone marrow edema. Pain scores (VAS 0-100) and radiomorphological measures (midline vertebral height, kyphosis angle) were analysed at baseline, postoperatively and after 12 months. RESULTS: In the "bone edema" group, pain scores improved from 72.7 to 46.8 (postoperative) and 48.0 (12 months, P < 0.001, both). In the group without preoperative bone edema, pain score improved from 70.7 to 60.3 (postoperative, P = 0.013) and to 50.1 (12 months, P = 0.001). Pain scores of both groups were significantly different directly postoperative (P = 0.026), but not after 12 months (P = 0.714). Vertebral height restoration was slightly greater in the "bone edema" group (10.2% vs. 7.8%, P = 0.289). Correction of the kyphosis angle was greater in the "bone edema" group (P = 0.014) compared to the "no bone edema" group (P = 0.838). CONCLUSION: A preoperative MR-detectable vertebral bone marrow edema predicts a better short-term outcome after kyphoplasty, but is not a prerequisite for long-term pain reduction in patients with old, chronically painful osteoporotic vertebral fractures.
Entities:
Keywords:
Back pain; Bone marrow edema; Kyphoplasty; MRI; Vertebral fracture
Authors: Christian Kasperk; Jochen Hillmeier; Gerd Nöldge; Ingo A Grafe; Katharina Dafonseca; Dorothea Raupp; Hubert Bardenheuer; Martin Libicher; Ute Monika Liegibel; Ulrike Sommer; Ulrike Hilscher; Walter Pyerin; Marcus Vetter; Hans-Peter Meinzer; Peter-Jürgen Meeder; Rod S Taylor; Peter Nawroth Journal: J Bone Miner Res Date: 2004-12-06 Impact factor: 6.741
Authors: M H J Voormolen; W J van Rooij; M Sluzewski; Y van der Graaf; L E H Lampmann; P N M Lohle; J R Juttmann Journal: AJNR Am J Neuroradiol Date: 2006-08 Impact factor: 3.825
Authors: Ingo A Grafe; Katharina Da Fonseca; Jochen Hillmeier; Peter-Jürgen Meeder; Martin Libicher; Gerd Nöldge; Hubert Bardenheuer; Walter Pyerin; Linus Basler; Christel Weiss; Rod S Taylor; Peter Nawroth; Christian Kasperk Journal: Osteoporos Int Date: 2005-08-03 Impact factor: 4.507