Lubna N Chaudhary1, Zeeshan Jawa2, Aniko Szabo3, Alexis Visotcky3, Christopher R Chitambar4. 1. Division of Hematology and Oncology, Medical College of Wisconsin, WI, USA. Electronic address: lchaudhary@mcw.edu. 2. Department of Internal Medicine, Medical College of Wisconsin, WI, USA. 3. Division of Biostatistics, Medical College of Wisconsin, WI, USA. 4. Division of Hematology and Oncology, Medical College of Wisconsin, WI, USA.
Abstract
OBJECTIVE/ BACKGROUND: Progesterone-receptor negativity (PR-) is predictive of adverse outcomes in estrogen receptor-positive (ER+) breast cancer. The Oncotype DX assay provides risk stratification for hormone receptor-positive (HR+) invasive breast cancer; however, the association of PR status and Oncotype DX recurrence scores (RSs) is less clear. METHODS: We designed an analysis to determine whether a significant difference exists in the RS for ER+/PR- tumors when compared with ER+/PR+ breast cancer. Three hundred and fifty patients with HR+ invasive breast cancer who underwent Oncotype DX testing at our institution from December 2006 to October 2013 were included. We also examined the concordance in the HR status reported by immunohistochemical (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses. The data were analyzed by analysis of variance, F test, t test, and chi-square tests. Multivariate linear regression was used to determine significant predictors of Oncotype DX RS. RESULTS: A total of 301 patients had ER+/PR+ tumors and 47 patients had ER+/PR- tumors by IHC. PR- tumors had a significantly higher RS than PR+ tumors (24.7±8.53 vs. 17.3±7.38; p<.001), predicting a greater 10-year risk of distant recurrence. Multivariate linear regression showed PR status and tumor grade to be significant predictors of Oncotype DX RS (p<.0001). A total of 284 patients had HR status reported by Oncotype DX assay. Concordance between IHC and RT-PCR was 99.3% for ER and 88.7% for PR. CONCLUSION: Our study shows that ER+/PR- breast cancer tumors are associated with a significantly higher Oncotype DX scores; this interprets into a higher risk of recurrence. Our data also show that the concordance between IHC and RT-PCR was 99.3% for ER and lower at 88.7% for PR.
OBJECTIVE/ BACKGROUND:Progesterone-receptor negativity (PR-) is predictive of adverse outcomes in estrogen receptor-positive (ER+) breast cancer. The Oncotype DX assay provides risk stratification for hormone receptor-positive (HR+) invasive breast cancer; however, the association of PR status and Oncotype DX recurrence scores (RSs) is less clear. METHODS: We designed an analysis to determine whether a significant difference exists in the RS for ER+/PR- tumors when compared with ER+/PR+ breast cancer. Three hundred and fifty patients with HR+ invasive breast cancer who underwent Oncotype DX testing at our institution from December 2006 to October 2013 were included. We also examined the concordance in the HR status reported by immunohistochemical (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses. The data were analyzed by analysis of variance, F test, t test, and chi-square tests. Multivariate linear regression was used to determine significant predictors of Oncotype DX RS. RESULTS: A total of 301 patients had ER+/PR+ tumors and 47 patients had ER+/PR- tumors by IHC. PR- tumors had a significantly higher RS than PR+ tumors (24.7±8.53 vs. 17.3±7.38; p<.001), predicting a greater 10-year risk of distant recurrence. Multivariate linear regression showed PR status and tumor grade to be significant predictors of Oncotype DX RS (p<.0001). A total of 284 patients had HR status reported by Oncotype DX assay. Concordance between IHC and RT-PCR was 99.3% for ER and 88.7% for PR. CONCLUSION: Our study shows that ER+/PR- breast cancer tumors are associated with a significantly higher Oncotype DX scores; this interprets into a higher risk of recurrence. Our data also show that the concordance between IHC and RT-PCR was 99.3% for ER and lower at 88.7% for PR.
Authors: Kathleen Van Asten; Laurence Slembrouck; Siel Olbrecht; Lynn Jongen; Olivier Brouckaert; Hans Wildiers; Giuseppe Floris; Erik Van Limbergen; Caroline Weltens; Ann Smeets; Robert Paridaens; Anita Giobbie-Hurder; Meredith M Regan; Giuseppe Viale; Beat Thürlimann; Ignace Vergote; Evangelia Christodoulou; Ben Van Calster; Patrick Neven Journal: Oncologist Date: 2018-08-31
Authors: Patrick Neven; Giuseppe Floris; Laurence Slembrouck; Isabelle Vanden Bempt; Hans Wildiers; Ann Smeets; Anne-Sophie Van Rompuy; Chantal Van Ongeval; Lynn Jongen; Caroline Weltens; Kevin Punie; Griet Hoste; Els Van Nieuwenhuysen; Sileny Han; Ines Nevelsteen Journal: Mod Pathol Date: 2021-02-08 Impact factor: 7.842
Authors: M G Davey; É J Ryan; P J Folan; N O'Halloran; M R Boland; M K Barry; K J Sweeney; C M Malone; R J McLaughlin; M J Kerin; A J Lowery Journal: BJS Open Date: 2021-05-07