BACKGROUND: This study was designed to assess the impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine (MIBG) indexes of cardiac sympathetic innervation. METHODS: Forty-five patients with heart failure (HF) (38 men, age 58±15 years) underwent (123)I-MIBG cardiac imaging. Of these patients, 10 were obese [body mass index (BMI) ≥30 kg/m(2)]. Ten-minute planar images of the thorax in anterior view were performed 15 minutes ("early" image) and 3 hours and 50 minutes ("late" image) after tracer administration in both supine- and prone-position. Early and late (123)I-MIBG heart-to-mediastinum (H/M) ratios and washout rate were computed. RESULTS: In overall study population, early and late (123)I-MIBG H/M ratios and washout rate were comparable between supine- and prone-position acquisitions. Obese patients had a lower early and late (123)I-MIBG H/M ratios both in supine (P<0.01) and prone (P<0.05) positions compared to non-obese subjects. CONCLUSIONS: Our results indicate that in HF patients, obesity has a significant impact on (123)I-MIBG indexes of cardiac sympathetic innervation. Prone-position did not change early and late (123)I-MIBG H/M ratios and washout rate compared to supine position both in obese and non-obese HF patients.
BACKGROUND: This study was designed to assess the impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine (MIBG) indexes of cardiac sympathetic innervation. METHODS: Forty-five patients with heart failure (HF) (38 men, age 58±15 years) underwent (123)I-MIBG cardiac imaging. Of these patients, 10 were obese [body mass index (BMI) ≥30 kg/m(2)]. Ten-minute planar images of the thorax in anterior view were performed 15 minutes ("early" image) and 3 hours and 50 minutes ("late" image) after tracer administration in both supine- and prone-position. Early and late (123)I-MIBG heart-to-mediastinum (H/M) ratios and washout rate were computed. RESULTS: In overall study population, early and late (123)I-MIBG H/M ratios and washout rate were comparable between supine- and prone-position acquisitions. Obesepatients had a lower early and late (123)I-MIBG H/M ratios both in supine (P<0.01) and prone (P<0.05) positions compared to non-obese subjects. CONCLUSIONS: Our results indicate that in HF patients, obesity has a significant impact on (123)I-MIBG indexes of cardiac sympathetic innervation. Prone-position did not change early and late (123)I-MIBG H/M ratios and washout rate compared to supine position both in obese and non-obese HFpatients.
Authors: Arnold F Jacobson; Roxy Senior; Manuel D Cerqueira; Nathan D Wong; Gregory S Thomas; Victor A Lopez; Denis Agostini; Fred Weiland; Harish Chandna; Jagat Narula Journal: J Am Coll Cardiol Date: 2010-02-25 Impact factor: 24.094
Authors: Tetsuo Sasano; M Roselle Abraham; Kuan-Cheng Chang; Hiroshi Ashikaga; Kevin J Mills; Daniel P Holt; John Hilton; Stephan G Nekolla; Jun Dong; Albert C Lardo; Henry Halperin; Robert F Dannals; Eduardo Marbán; Frank M Bengel Journal: J Am Coll Cardiol Date: 2008-06-10 Impact factor: 24.094
Authors: M Petretta; D Bonaduce; E de Filippo; G F Mureddu; L Scalfi; F Marciano; V Bianchi; L Salemme; G de Simone; F Contaldo Journal: Eur J Clin Invest Date: 1995-11 Impact factor: 4.686
Authors: Jeroen J Bax; Otakar Kraft; Alfred E Buxton; Jan Gunnar Fjeld; Petr Parízek; Denis Agostini; Juhani Knuuti; Albert Flotats; James Arrighi; Africa Muxi; Marie-Jeanne Alibelli; Gopa Banerjee; Arnold F Jacobson Journal: Circ Cardiovasc Imaging Date: 2008-07-30 Impact factor: 7.792
Authors: Jared P Reis; Caroline A Macera; Maria R Araneta; Suzanne P Lindsay; Simon J Marshall; Deborah L Wingard Journal: Obesity (Silver Spring) Date: 2009-02-05 Impact factor: 5.002
Authors: Hein J Verberne; G Aernout Somsen; Pavol Povinec; Berthe L F van Eck-Smit; Arnold F Jacobson Journal: Eur J Nucl Med Mol Imaging Date: 2009-03-04 Impact factor: 9.236
Authors: Sophie I Mavrogeni; Flora Bacopoulou; George Markousis-Mavrogenis; George Chrousos; Evangelia Charmandari Journal: Nutrients Date: 2021-02-26 Impact factor: 5.717
Authors: G Roberts; J J Lloyd; J P M Kane; R Durcan; S Lawley; K Howe; G S Petrides; J T O'Brien; A J Thomas Journal: J Nucl Cardiol Date: 2019-09-16 Impact factor: 5.952