G Roberts1,2, J J Lloyd3,4, J P M Kane3, R Durcan3, S Lawley3, K Howe4, G S Petrides4, J T O'Brien5, A J Thomas3. 1. Institute of Neuroscience, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK. gemma.roberts@newcastle.ac.uk. 2. Nuclear Medicine Department, Leazes Wing, Royal Victoria Infirmary, Richardson Road, Newcastle upon Tyne, NE1 4LP, UK. gemma.roberts@newcastle.ac.uk. 3. Institute of Neuroscience, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK. 4. Nuclear Medicine Department, Leazes Wing, Royal Victoria Infirmary, Richardson Road, Newcastle upon Tyne, NE1 4LP, UK. 5. Department of Psychiatry, University of Cambridge, Box 189, Level E4 Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Abstract
PURPOSE: Cardiac 123I-MIBG image interpretation is affected by population differences and technical factors. We recruited older adults without cognitive decline and compared their cardiac MIBG uptake with results from the literature. METHODS: Phantom calibration confirmed that cardiac uptake results from Japan could be applied to our center. We recruited 31 controls, 17 individuals with dementia with Lewy bodies (DLB) and 15 with Alzheimer's disease (AD). Images were acquired 20 minutes and four hours after injection using Siemens cameras with medium-energy low-penetration (MELP) collimators. Local normal heart-to-mediastinum (HMR) ratios were compared to Japanese results. RESULTS: Siemens gamma cameras with MELP collimators should give HMRs very close to the calibrated values used in Japan. However, our cut-offs with controls were lower at 2.07 for early and 1.86 for delayed images. Applying our lower cut-off to the dementia patients may increase the specificity of cardiac MIBG imaging for DLB diagnosis in a UK population without reducing sensitivity. CONCLUSIONS: Our local HMR cut-off values are lower than in Japan, higher than in a large US study but similar to those found in another UK center. UK centers using other cameras and collimators may need to use different cut-offs to apply our results.
PURPOSE: Cardiac 123I-MIBG image interpretation is affected by population differences and technical factors. We recruited older adults without cognitive decline and compared their cardiac MIBG uptake with results from the literature. METHODS: Phantom calibration confirmed that cardiac uptake results from Japan could be applied to our center. We recruited 31 controls, 17 individuals with dementia with Lewy bodies (DLB) and 15 with Alzheimer's disease (AD). Images were acquired 20 minutes and four hours after injection using Siemens cameras with medium-energy low-penetration (MELP) collimators. Local normal heart-to-mediastinum (HMR) ratios were compared to Japanese results. RESULTS: Siemens gamma cameras with MELP collimators should give HMRs very close to the calibrated values used in Japan. However, our cut-offs with controls were lower at 2.07 for early and 1.86 for delayed images. Applying our lower cut-off to the dementia patients may increase the specificity of cardiac MIBG imaging for DLB diagnosis in a UK population without reducing sensitivity. CONCLUSIONS: Our local HMR cut-off values are lower than in Japan, higher than in a large US study but similar to those found in another UK center. UK centers using other cameras and collimators may need to use different cut-offs to apply our results.
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Authors: Gemma Roberts; Joseph P M Kane; Jim Lloyd; Michael Firbank; Paul Christopher Donaghy; George S Petrides; John-Paul Taylor; John O'Brien; Alan J Thomas Journal: Nucl Med Commun Date: 2022-05-20 Impact factor: 1.698
Authors: Alan J Thomas; Calum A Hamilton; Amanda Heslegrave; Sally Barker; Rory Durcan; Sarah Lawley; Nicola Barnett; Debbie Lett; Michael Firbank; Gemma Roberts; John-Paul Taylor; Paul C Donaghy; Henrik Zetterberg; John O'Brien Journal: Mov Disord Date: 2022-03-23 Impact factor: 9.698
Authors: Gemma Roberts; Rory Durcan; Paul C Donaghy; Sarah Lawley; Joanna Ciafone; Calum A Hamilton; Sean J Colloby; Michael J Firbank; Louise Allan; Nicola Barnett; Sally Barker; Kim Howe; Tamir Ali; George S Petrides; Jim Lloyd; John-Paul Taylor; John O'Brien; Alan J Thomas Journal: Neurology Date: 2021-04-21 Impact factor: 9.910
Authors: Michael J Firbank; John T O'Brien; Rory Durcan; Louise M Allan; Sally Barker; Joanna Ciafone; Paul C Donaghy; Calum A Hamilton; Sarah Lawley; Jim Lloyd; Gemma Roberts; John-Paul Taylor; Alan J Thomas Journal: J Neurol Date: 2020-10-21 Impact factor: 4.849