Literature DB >> 26790771

Risky business: Microhomology-mediated end joining.

Supriya Sinha1, Diana Villarreal2, Eun Yong Shim3, Sang Eun Lee4.   

Abstract

Prevalence of microhomology (MH) at the breakpoint junctions in somatic and germ-line chromosomal rearrangements and in the programmed immune receptor rearrangements from cells deficient in classical end joining reveals an enigmatic process called MH-mediated end joining (MMEJ). MMEJ repairs DNA double strand breaks (DSBs) by annealing flanking MH and deleting genetic information at the repair junctions from yeast to humans. Being genetically distinct from canonical DNA DSB pathways, MMEJ is involved with the fusions of eroded/uncapped telomeres as well as with the assembly of chromosome fragments in chromothripsis. In this review article, we will discuss an up-to-date model representing the MMEJ process and the mechanism by which cells regulate MMEJ to limit repair-associated mutagenesis. We will also describe the possible therapeutic gains resulting from the inhibition of MMEJ in recombination deficient cancers. Lastly, we will embark on two contentious issues associated with MMEJ such as the significance of MH at the repair junction to be the hallmark of MMEJ and the relationship of MMEJ to other mechanistically related DSB repair pathways.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Chromosomal rearrangements; DNA double strand break repair; Microhomology

Mesh：

Year:  2016        PMID： 26790771      PMCID： PMC4887395          DOI： 10.1016/j.mrfmmm.2015.12.005

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  91 in total

1.  Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.

Authors:  L A Tobin; C Robert; A P Rapoport; I Gojo; M R Baer; A E Tomkinson; F V Rassool
Journal:  Oncogene       Date:  2012-05-28       Impact factor: 9.867

2.  CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.

Authors:  Hailong Wang; Zhengping Shao; Linda Z Shi; Patty Yi-Hwa Hwang; Lan N Truong; Michael W Berns; David J Chen; Xiaohua Wu
Journal:  J Biol Chem       Date:  2012-04-27       Impact factor: 5.157

3.  Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.

Authors:  Cristian Boboila; Mila Jankovic; Catherine T Yan; Jing H Wang; Duane R Wesemann; Tingting Zhang; Alex Fazeli; Lauren Feldman; Andre Nussenzweig; Michel Nussenzweig; Frederick W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-25       Impact factor: 11.205

4.  Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.

Authors:  Farjana Fattah; Eu Han Lee; Natalie Weisensel; Yongbao Wang; Natalie Lichter; Eric A Hendrickson
Journal:  PLoS Genet       Date:  2010-02-26       Impact factor: 5.917

5.  The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans.

Authors:  Feng Zhang; Mehrdad Khajavi; Anne M Connolly; Charles F Towne; Sat Dev Batish; James R Lupski
Journal:  Nat Genet       Date:  2009-06-21       Impact factor: 38.330

6.  Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ.

Authors:  Tatiana Kent; Gurushankar Chandramouly; Shane Michael McDevitt; Ahmet Y Ozdemir; Richard T Pomerantz
Journal:  Nat Struct Mol Biol       Date:  2015-02-02       Impact factor: 15.369

7.  Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9.

Authors:  Shota Nakade; Takuya Tsubota; Yuto Sakane; Satoshi Kume; Naoaki Sakamoto; Masanobu Obara; Takaaki Daimon; Hideki Sezutsu; Takashi Yamamoto; Tetsushi Sakuma; Ken-ichi T Suzuki
Journal:  Nat Commun       Date:  2014-11-20       Impact factor: 14.919

8.  DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.

Authors:  Grzegorz Ira; Achille Pellicioli; Alitukiriza Balijja; Xuan Wang; Simona Fiorani; Walter Carotenuto; Giordano Liberi; Debra Bressan; Lihong Wan; Nancy M Hollingsworth; James E Haber; Marco Foiani
Journal:  Nature       Date:  2004-10-21       Impact factor: 49.962

9.  Escape from telomere-driven crisis is DNA ligase III dependent.

Authors:  Rhiannon E Jones; Sehyun Oh; Julia W Grimstead; Jacob Zimbric; Laureline Roger; Nicole H Heppel; Kevin E Ashelford; Kate Liddiard; Eric A Hendrickson; Duncan M Baird
Journal:  Cell Rep       Date:  2014-08-07       Impact factor: 9.423

10.  DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates.

Authors:  Katja Paul; Minli Wang; Emil Mladenov; Alena Bencsik-Theilen; Theresa Bednar; Wenqi Wu; Hiroshi Arakawa; George Iliakis
Journal:  PLoS One       Date:  2013-03-28       Impact factor: 3.240
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  30 in total

Review 1.  p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks.

Authors:  Howard B Lieberman; Sunil K Panigrahi; Kevin M Hopkins; Li Wang; Constantinos G Broustas
Journal:  Radiat Res       Date:  2017-01-31       Impact factor: 2.841

Review 2.  Ways of improving precise knock-in by genome-editing technologies.

Authors:  Svetlana A Smirnikhina; Arina A Anuchina; Alexander V Lavrov
Journal:  Hum Genet       Date:  2018-11-02       Impact factor: 4.132

Review 3.  Microhomology-mediated end joining: Good, bad and ugly.

Authors:  Ja-Hwan Seol; Eun Yong Shim; Sang Eun Lee
Journal:  Mutat Res       Date:  2017-07-16       Impact factor: 2.433

4.  Catastrophic Unbalanced Genome Rearrangements Cause Somatic Loss of Berry Color in Grapevine.

Authors:  Pablo Carbonell-Bejerano; Carolina Royo; Rafael Torres-Pérez; Jérôme Grimplet; Lucie Fernandez; José Manuel Franco-Zorrilla; Diego Lijavetzky; Elisa Baroja; Juana Martínez; Enrique García-Escudero; Javier Ibáñez; José Miguel Martínez-Zapater
Journal:  Plant Physiol       Date:  2017-08-15       Impact factor: 8.340

5.  Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions.

Authors:  Klaas Schotanus; Joseph Heitman
Journal:  Elife       Date:  2020-04-20       Impact factor: 8.140

6.  Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.

Authors:  Charlene H Emerson; Christopher R Lopez; Albert Ribes-Zamora; Erica J Polleys; Christopher L Williams; Lythou Yeo; Jacques E Zaneveld; Rui Chen; Alison A Bertuch
Journal:  Genetics       Date:  2018-03-02       Impact factor: 4.562

7.  Birth of a W sex chromosome by horizontal transfer of Wolbachia bacterial symbiont genome.

Authors:  Sébastien Leclercq; Julien Thézé; Mohamed Amine Chebbi; Isabelle Giraud; Bouziane Moumen; Lise Ernenwein; Pierre Grève; Clément Gilbert; Richard Cordaux
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-06       Impact factor: 11.205

Review 8.  Regulation of non-homologous end joining via post-translational modifications of components of the ligation step.

Authors:  Kristína Durdíková; Miroslav Chovanec
Journal:  Curr Genet       Date:  2016-12-03       Impact factor: 3.886

9.  Mycobacterium tuberculosis and Mycobacterium marinum non-homologous end-joining proteins can function together to join DNA ends in Escherichia coli.

Authors:  Douglas G Wright; Reneau Castore; Runhua Shi; Amrita Mallick; Don G Ennis; Lynn Harrison
Journal:  Mutagenesis       Date:  2017-03-01       Impact factor: 3.000

10.  Rtt105 promotes high-fidelity DNA replication and repair by regulating the single-stranded DNA-binding factor RPA.

Authors:  Xuejie Wang; Yang Dong; Xiaocong Zhao; Jinbao Li; Jordan Lee; Zhenxin Yan; Shuangshuang Yang; Wenqiang Wu; Ximiao Hou; Guangxue Liu; Yueyue Zhang; Lun Song; Gang Cai; Qing Li; Grzegorz Ira; Xinghua Zhang; Xuefeng Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2021-06-22       Impact factor: 11.205
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