Literature DB >> 26758492

Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601.

Takuji Nakashima1, Rei Miyano2, Masato Iwatsuki1,2, Tatsuya Shirahata3, Toru Kimura2, Yukihiro Asami1, Yoshinori Kobayashi3, Kazuro Shiomi1,2, George A Petersson4, Yōko Takahashi1, Satoshi Ōmura1.   

Abstract

A new natural product, designated iminimycin A, was isolated from the cultured broth of a streptomycin-producing microbial strain, Streptomyces griseus OS-3601, via a physicochemical screening method using HP-20, silica gel and ODS column chromatographies and subsequent preparative HPLC. Iminimycin A is an indolizidine alkaloid, containing of an unusual iminium group and a cyclopropane ring with a triene side chain. The absolute configuration of iminimycin A was elucidated by NMR studies and electronic circular dichroism analysis. Iminimycin A shows anti-bacterial activity against Bacillus subtilis, Kocuria rhizophila and Xanthomonas campestris pv. orizae, and cytotoxic activity against HeLa S3 and Jurkat cells with IC50 values of 43 and 36 μM, respectively.

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Year:  2016        PMID： 26758492     DOI： 10.1038/ja.2015.142

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  23 in total

Review 1.  Bioactive microbial metabolites.

Authors:  János Bérdy
Journal:  J Antibiot (Tokyo)       Date:  2005-01       Impact factor: 2.649

2.  Dysinosin A: a novel inhibitor of Factor VIIa and thrombin from a new genus and species of Australian sponge of the family Dysideidae.

Authors:  Anthony R Carroll; Gregory K Pierens; Greg Fechner; Priscila De Almeida Leone; Anna Ngo; Moana Simpson; Edward Hyde; John N A Hooper; Stig-Lennart Boström; Djordje Musil; Ronald J Quinn
Journal:  J Am Chem Soc       Date:  2002-11-13       Impact factor: 15.419

3.  Mangromicin C, a new analog of mangromicin.

Authors:  Takuji Nakashima; Yoshiyuki Kamiya; Masato Iwatsuki; Noriko Sato; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2014-10-01       Impact factor: 2.649

4.  Macropodumines A-C: novel pentacyclic alkaloids with an unusual skeleton or zwitterion moiety from Daphniphyllum macropodum Miq.

Authors:  Wen Zhang; Yue-Wei Guo; Karsten Krohn
Journal:  Chemistry       Date:  2006-06-23       Impact factor: 5.236

5.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

Authors:  S D Bentley; K F Chater; A-M Cerdeño-Tárraga; G L Challis; N R Thomson; K D James; D E Harris; M A Quail; H Kieser; D Harper; A Bateman; S Brown; G Chandra; C W Chen; M Collins; A Cronin; A Fraser; A Goble; J Hidalgo; T Hornsby; S Howarth; C-H Huang; T Kieser; L Larke; L Murphy; K Oliver; S O'Neil; E Rabbinowitsch; M-A Rajandream; K Rutherford; S Rutter; K Seeger; D Saunders; S Sharp; R Squares; S Squares; K Taylor; T Warren; A Wietzorrek; J Woodward; B G Barrell; J Parkhill; D A Hopwood
Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

6.  New compounds, nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966.

Authors:  Takuji Nakashima; Panitch Boonsnongcheep; Toru Kimura; Masato Iwatsuki; Noriko Sato; Kenichi Nonaka; Sompop Prathanturarug; Yōko Takahashi; Satoshi Ōmura
Journal:  J Biosci Bioeng       Date:  2015-06-20       Impact factor: 2.894

7.  A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.

Authors:  S Omura; Y Iwai; A Hirano; A Nakagawa; J Awaya; H Tsuchya; Y Takahashi; R Masuma
Journal:  J Antibiot (Tokyo)       Date:  1977-04       Impact factor: 2.649

8.  A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil.

Authors:  Miho Izumikawa; Takahiro Hosoya; Motoki Takagi; Kazuo Shin-ya
Journal:  J Antibiot (Tokyo)       Date:  2011-11-02       Impact factor: 2.649

9.  Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510.

Authors:  Takuji Nakashima; Ryuki Okuyama; Yoshiyuki Kamiya; Atsuko Matsumoto; Masato Iwatsuki; Yuki Inahashi; Kenzaburo Yamaji; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2013-04-17       Impact factor: 2.649

Review 10.  Circular dichroism calculation for natural products.

Authors:  Alfarius Eko Nugroho; Hiroshi Morita
Journal:  J Nat Med       Date:  2013-04-07       Impact factor: 2.343
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  3 in total

1.  Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.

Authors:  Yoshihiro Watanabe; Yukihiro Asami; Satomi Narusawa; Shohei Hashimoto; Masato Iwatsuki; Kenichi Nonaka; Yasuo Shinohara; Takahiro Shiotsuki; Naoya Ichimaru; Hideto Miyoshi; Satoshi Ōmura; Kazuro Shiomi
Journal:  J Antibiot (Tokyo)       Date:  2017-10-11       Impact factor: 2.649

Review 2.  Actinomycetes, an Inexhaustible Source of Naturally Occurring Antibiotics.

Authors:  Yōko Takahashi; Takuji Nakashima
Journal:  Antibiotics (Basel)       Date:  2018-05-24

Review 3.  Novel Alkaloids from Marine Actinobacteria: Discovery and Characterization.

Authors:  Anne-Sofie De Rop; Jeltien Rombaut; Thomas Willems; Marilyn De Graeve; Lynn Vanhaecke; Paco Hulpiau; Sofie L De Maeseneire; Maarten L De Mol; Wim K Soetaert
Journal:  Mar Drugs       Date:  2021-12-22       Impact factor: 5.118
  3 in total

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