Literature DB >> 29018265

Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.

Yoshihiro Watanabe1, Yukihiro Asami1,2, Satomi Narusawa3, Shohei Hashimoto3, Masato Iwatsuki1,2, Kenichi Nonaka1,2, Yasuo Shinohara4, Takahiro Shiotsuki5, Naoya Ichimaru6, Hideto Miyoshi7, Satoshi Ōmura2, Kazuro Shiomi1,2.   

Abstract

A new lanostane-type triterpenoid, ascosteroside D, was isolated from a fungus, Aspergillus sp. FKI-6682. It inhibited insect ADP/ATP carrier protein (AAC)-expressing Saccharomyces cerevisiae in glycerol-containing medium, but did not inhibit Δaac S. cerevisiae in glucose-containing medium. It is hypothesized that ascosteroside D inhibits ATP production in mitochondria.The Journal of Antibiotics advance online publication, 11 October 2017; doi:10.1038/ja.2017.118.

Entities:  

Year:  2017        PMID： 29018265     DOI： 10.1038/ja.2017.118

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae.

Authors:  Takuya Suga; Yukihiro Asami; Shohei Hashimoto; Kenichi Nonaka; Masato Iwatsuki; Takuji Nakashima; Ryohei Sugahara; Takahiro Shiotsuki; Takenori Yamamoto; Yasuo Shinohara; Naoya Ichimaru; Masatoshi Murai; Hideto Miyoshi; Satoshi Ōmura; Kazuro Shiomi
Journal:  J Antibiot (Tokyo)       Date:  2015-05-06       Impact factor: 2.649

2.  Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601.

Authors:  Takuji Nakashima; Rei Miyano; Masato Iwatsuki; Tatsuya Shirahata; Toru Kimura; Yukihiro Asami; Yoshinori Kobayashi; Kazuro Shiomi; George A Petersson; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2016-01-13       Impact factor: 2.649

3.  [Mucidin, the first Czechoslovakian antibiotic].

Authors:  P Ago
Journal:  Minerva Med       Date:  1970-09-25       Impact factor: 4.806

4.  Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.

Authors:  T Friedrich; P van Heek; H Leif; T Ohnishi; E Forche; B Kunze; R Jansen; W Trowitzsch-Kienast; G Höfle; H Reichenbach
Journal:  Eur J Biochem       Date:  1994-01-15

5.  Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system.

Authors:  Takuya Suga; Yukihiro Asami; Shohei Hashimoto; Kenichi Nonaka; Masato Iwatsuki; Takuji Nakashima; Yoshihiro Watanabe; Ryohei Sugahara; Takahiro Shiotsuki; Takenori Yamamoto; Yasuo Shinohara; Naoya Ichimaru; Masatoshi Murai; Hideto Miyoshi; Satoshi Ōmura; Kazuro Shiomi
Journal:  J Gen Appl Microbiol       Date:  2015       Impact factor: 1.452

6.  Expression of the bovine heart mitochondrial ADP/ATP carrier in yeast mitochondria: significantly enhanced expression by replacement of the N-terminal region of the bovine carrier by the corresponding regions of the yeast carriers.

Authors:  M Hashimoto; Y Shinohara; E Majima; T Hatanaka; N Yamazaki; H Terada
Journal:  Biochim Biophys Acta       Date:  1999-01-05
  6 in total

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