| Literature DB >> 23591606 |
Takuji Nakashima1, Ryuki Okuyama, Yoshiyuki Kamiya, Atsuko Matsumoto, Masato Iwatsuki, Yuki Inahashi, Kenzaburo Yamaji, Yōko Takahashi, Satoshi Ōmura.
Abstract
Three new natural products, designated trehangelins A, B and C, were isolated by solvent extraction, silica gel and octadecylsilyl silica gel column chromatographies and subsequent preparative HPLC from the cultured broth of an endophytic actinomycete strain, Polymorphospora rubra K07-0510. The trehangelins consisted of a trehalose moiety and two angelic acid moieties. Trehangelins A (IC50 value, 0.1 mg ml(-1)) and C (IC50 value, 0.4 mg ml(-1)), with symmetric structures, showed potent inhibitory activity against hemolysis of red blood cells induced by light-activated pheophorbide a. However, trehangelin B, with an asymmetric structure, displayed only a slight inhibition (IC50 value, 1.0 mg ml(-1)).Entities:
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Year: 2013 PMID： 23591606 DOI： 10.1038/ja.2013.17
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649