BACKGROUND: Rescue and recovery workers responding to the 2001 collapse of the World Trade Center (WTC) sustained exposures to toxic chemicals and have elevated rates of multiple morbidities. METHODS: Using data from the World Trade Center Health Program and the National Death Index for 2002-2011, we examined standardized mortality ratios (SMR) and proportional cancer mortality ratios (PCMR) with indirect standardization for age, sex, race, and calendar year to the U.S. general population, as well as associations between WTC-related environmental exposures and all-cause mortality. RESULTS: We identified 330 deaths among 28,918 responders (SMR 0.43, 95%CI 0.39-0.48). No cause-specific SMRs were meaningfully elevated. PCMRs were elevated for neoplasms of lymphatic and hematopoietic tissue (PCMR 1.76, 95%CI 1.06-2.75). Mortality hazard ratios showed no linear trend with exposure. CONCLUSIONS: Consistent with a healthy worker effect, all-cause mortality among responders was not elevated. There was no clear association between intensity and duration of exposure and mortality. Surveillance is needed to monitor the proportionally higher cancer mortality attributed to lymphatic/hematopoietic neoplasms.
BACKGROUND: Rescue and recovery workers responding to the 2001 collapse of the World Trade Center (WTC) sustained exposures to toxic chemicals and have elevated rates of multiple morbidities. METHODS: Using data from the World Trade Center Health Program and the National Death Index for 2002-2011, we examined standardized mortality ratios (SMR) and proportional cancer mortality ratios (PCMR) with indirect standardization for age, sex, race, and calendar year to the U.S. general population, as well as associations between WTC-related environmental exposures and all-cause mortality. RESULTS: We identified 330 deaths among 28,918 responders (SMR 0.43, 95%CI 0.39-0.48). No cause-specific SMRs were meaningfully elevated. PCMRs were elevated for neoplasms of lymphatic and hematopoietic tissue (PCMR 1.76, 95%CI 1.06-2.75). Mortality hazard ratios showed no linear trend with exposure. CONCLUSIONS: Consistent with a healthy worker effect, all-cause mortality among responders was not elevated. There was no clear association between intensity and duration of exposure and mortality. Surveillance is needed to monitor the proportionally higher cancer mortality attributed to lymphatic/hematopoietic neoplasms.
Authors: Rachel Zeig-Owens; Mayris P Webber; Charles B Hall; Theresa Schwartz; Nadia Jaber; Jessica Weakley; Thomas E Rohan; Hillel W Cohen; Olga Derman; Thomas K Aldrich; Kerry Kelly; David J Prezant Journal: Lancet Date: 2011-09-03 Impact factor: 79.321
Authors: Hannah T Jordan; Robert M Brackbill; James E Cone; Indira Debchoudhury; Mark R Farfel; Carolyn M Greene; James L Hadler; Joseph Kennedy; Jiehui Li; Jonathan Liff; Leslie Stayner; Steven D Stellman Journal: Lancet Date: 2011-09-03 Impact factor: 79.321
Authors: Juan P Wisnivesky; Susan L Teitelbaum; Andrew C Todd; Paolo Boffetta; Michael Crane; Laura Crowley; Rafael E de la Hoz; Cornelia Dellenbaugh; Denise Harrison; Robin Herbert; Hyun Kim; Yunho Jeon; Julia Kaplan; Craig Katz; Stephen Levin; Ben Luft; Steven Markowitz; Jacqueline M Moline; Fatih Ozbay; Robert H Pietrzak; Moshe Shapiro; Vansh Sharma; Gwen Skloot; Steven Southwick; Lori A Stevenson; Iris Udasin; Sylvan Wallenstein; Philip J Landrigan Journal: Lancet Date: 2011-09-03 Impact factor: 202.731
Authors: Robin Herbert; Jacqueline Moline; Gwen Skloot; Kristina Metzger; Sherry Baron; Benjamin Luft; Steven Markowitz; Iris Udasin; Denise Harrison; Diane Stein; Andrew Todd; Paul Enright; Jeanne Mager Stellman; Philip J Landrigan; Stephen M Levin Journal: Environ Health Perspect Date: 2006-12 Impact factor: 9.031
Authors: Samara Solan; Sylvan Wallenstein; Moshe Shapiro; Susan L Teitelbaum; Lori Stevenson; Anne Kochman; Julia Kaplan; Cornelia Dellenbaugh; Amy Kahn; F Noah Biro; Michael Crane; Laura Crowley; Janice Gabrilove; Lou Gonsalves; Denise Harrison; Robin Herbert; Benjamin Luft; Steven B Markowitz; Jacqueline Moline; Xiaoling Niu; Henry Sacks; Gauri Shukla; Iris Udasin; Roberto G Lucchini; Paolo Boffetta; Philip J Landrigan Journal: Environ Health Perspect Date: 2013-04-23 Impact factor: 9.031
Authors: Dana Hashim; Paolo Boffetta; Matthew Galsky; William Oh; Roberto Lucchini; Michael Crane; Benjamin Luft; Jaqueline Moline; Iris Udasin; Denise Harrison; Emanuela Taioli Journal: Eur J Cancer Prev Date: 2018-07 Impact factor: 2.497
Authors: Matthew J Mears; David M Aslaner; Chad T Barson; Mitchell D Cohen; Matthew W Gorr; Loren E Wold Journal: Life Sci Date: 2021-11-14 Impact factor: 5.037
Authors: Ghalib A Bello; Katherine A Ornstein; Roberto G Lucchini; William W Hung; Fred C Ko; Elena Colicino; Emanuela Taioli; Michael A Crane; Andrew C Todd Journal: J Aging Health Date: 2021-03-12
Authors: Ghalib A Bello; Roberto G Lucchini; Susan L Teitelbaum; Moshe Shapiro; Michael A Crane; Andrew C Todd Journal: Curr Gerontol Geriatr Res Date: 2018-02-26
Authors: Alpo Vuorio; Tanja Laukkala; Ilkka Junttila; Robert Bor; Bruce Budowle; Eero Pukkala; Pooshan Navathe; Antti Sajantila Journal: Int J Environ Res Public Health Date: 2018-11-12 Impact factor: 3.390
Authors: Albeliz Santiago-Colón; Robert Daniels; Dori Reissman; Kristi Anderson; Geoffrey Calvert; Alexis Caplan; Tania Carreón; Alan Katruska; Travis Kubale; Ruiling Liu; Rhonda Nembhard; W Allen Robison; James Yiin; John Howard Journal: Int J Environ Res Public Health Date: 2020-10-06 Impact factor: 3.390
Authors: David G Goldfarb; Rachel Zeig-Owens; Dana Kristjansson; Jiehui Li; Robert M Brackbill; Mark R Farfel; James E Cone; Amy R Kahn; Baozhen Qiao; Maria J Schymura; Mayris P Webber; Christopher R Dasaro; Roberto G Lucchini; Andrew C Todd; David J Prezant; Charles B Hall; Paolo Boffetta Journal: Am J Ind Med Date: 2021-07-19 Impact factor: 3.079