Literature DB >> 21890053

Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study.

Juan P Wisnivesky1, Susan L Teitelbaum, Andrew C Todd, Paolo Boffetta, Michael Crane, Laura Crowley, Rafael E de la Hoz, Cornelia Dellenbaugh, Denise Harrison, Robin Herbert, Hyun Kim, Yunho Jeon, Julia Kaplan, Craig Katz, Stephen Levin, Ben Luft, Steven Markowitz, Jacqueline M Moline, Fatih Ozbay, Robert H Pietrzak, Moshe Shapiro, Vansh Sharma, Gwen Skloot, Steven Southwick, Lori A Stevenson, Iris Udasin, Sylvan Wallenstein, Philip J Landrigan.   

Abstract

BACKGROUND: More than 50,000 people participated in the rescue and recovery work that followed the Sept 11, 2001 (9/11) attacks on the World Trade Center (WTC). Multiple health problems in these workers were reported in the early years after the disaster. We report incidence and prevalence rates of physical and mental health disorders during the 9 years since the attacks, examine their associations with occupational exposures, and quantify physical and mental health comorbidities.
METHODS: In this longitudinal study of a large cohort of WTC rescue and recovery workers, we gathered data from 27,449 participants in the WTC Screening, Monitoring, and Treatment Program. The study population included police officers, firefighters, construction workers, and municipal workers. We used the Kaplan-Meier procedure to estimate cumulative and annual incidence of physical disorders (asthma, sinusitis, and gastro-oesophageal reflux disease), mental health disorders (depression, post-traumatic stress disorder [PTSD], and panic disorder), and spirometric abnormalities. Incidence rates were assessed also by level of exposure (days worked at the WTC site and exposure to the dust cloud).
FINDINGS: 9-year cumulative incidence of asthma was 27·6% (number at risk: 7027), sinusitis 42·3% (5870), and gastro-oesophageal reflux disease 39·3% (5650). In police officers, cumulative incidence of depression was 7·0% (number at risk: 3648), PTSD 9·3% (3761), and panic disorder 8·4% (3780). In other rescue and recovery workers, cumulative incidence of depression was 27·5% (number at risk: 4200), PTSD 31·9% (4342), and panic disorder 21·2% (4953). 9-year cumulative incidence for spirometric abnormalities was 41·8% (number at risk: 5769); three-quarters of these abnormalities were low forced vital capacity. Incidence of most disorders was highest in workers with greatest WTC exposure. Extensive comorbidity was reported within and between physical and mental health disorders.
INTERPRETATION: 9 years after the 9/11 WTC attacks, rescue and recovery workers continue to have a substantial burden of physical and mental health problems. These findings emphasise the need for continued monitoring and treatment of the WTC rescue and recovery population. FUNDING: Centers for Disease Control and Prevention and National Institute for Occupational Safety and Health.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21890053      PMCID: PMC9453925          DOI: 10.1016/S0140-6736(11)61180-X

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   202.731


  30 in total

1.  Cough and bronchial responsiveness in firefighters at the World Trade Center site.

Authors:  David J Prezant; Michael Weiden; Gisela I Banauch; Georgeann McGuinness; William N Rom; Thomas K Aldrich; Kerry J Kelly
Journal:  N Engl J Med       Date:  2002-09-09       Impact factor: 91.245

2.  Respiratory symptoms were associated with lower spirometry results during the first examination of WTC responders.

Authors:  Iris Udasin; Clyde Schechter; Laura Crowley; Anays Sotolongo; Michael Gochfeld; Benjamin Luft; Jacqueline Moline; Denise Harrison; Paul Enright
Journal:  J Occup Environ Med       Date:  2011-01       Impact factor: 2.162

3.  Interpretative strategies for lung function tests.

Authors:  R Pellegrino; G Viegi; V Brusasco; R O Crapo; F Burgos; R Casaburi; A Coates; C P M van der Grinten; P Gustafsson; J Hankinson; R Jensen; D C Johnson; N MacIntyre; R McKay; M R Miller; D Navajas; O F Pedersen; J Wanger
Journal:  Eur Respir J       Date:  2005-11       Impact factor: 16.671

4.  Obstructive airways disease with air trapping among firefighters exposed to World Trade Center dust.

Authors:  Michael D Weiden; Natalia Ferrier; Anna Nolan; William N Rom; Ashley Comfort; Jackson Gustave; Rachel Zeig-Owens; Shugi Zheng; Roberta M Goldring; Kenneth I Berger; Kaitlyn Cosenza; Roy Lee; Mayris P Webber; Kerry J Kelly; Thomas K Aldrich; David J Prezant
Journal:  Chest       Date:  2009-10-09       Impact factor: 9.410

5.  Long-term posttraumatic stress symptoms among 3,271 civilian survivors of the September 11, 2001, terrorist attacks on the World Trade Center.

Authors:  Laura DiGrande; Yuval Neria; Robert M Brackbill; Paul Pulliam; Sandro Galea
Journal:  Am J Epidemiol       Date:  2010-12-29       Impact factor: 4.897

6.  Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.

Authors:  R L Spitzer; K Kroenke; J B Williams
Journal:  JAMA       Date:  1999-11-10       Impact factor: 56.272

7.  "Sarcoid like" granulomatous pulmonary disease in World Trade Center disaster responders.

Authors:  Laura E Crowley; Robin Herbert; Jacqueline M Moline; Sylvan Wallenstein; Gauri Shukla; Clyde Schechter; Gwen S Skloot; Iris Udasin; Benjamin J Luft; Denise Harrison; Moshe Shapiro; Karen Wong; Henry S Sacks; Philip J Landrigan; Alvin S Teirstein
Journal:  Am J Ind Med       Date:  2010-12-22       Impact factor: 2.214

8.  Epidemiologic research on man-made disasters: strategies and implications of cohort definition for World Trade Center worker and volunteer surveillance program.

Authors:  David A Savitz; Rachael T Oxman; Kristina B Metzger; Sylvan Wallenstein; Diane Stein; Jacqueline M Moline; Robin Herbert
Journal:  Mt Sinai J Med       Date:  2008 Mar-Apr

Review 9.  Occupational asthma: a review.

Authors:  L J Lombardo; J R Balmes
Journal:  Environ Health Perspect       Date:  2000-08       Impact factor: 9.031

10.  The World Trade Center disaster and the health of workers: five-year assessment of a unique medical screening program.

Authors:  Robin Herbert; Jacqueline Moline; Gwen Skloot; Kristina Metzger; Sherry Baron; Benjamin Luft; Steven Markowitz; Iris Udasin; Denise Harrison; Diane Stein; Andrew Todd; Paul Enright; Jeanne Mager Stellman; Philip J Landrigan; Stephen M Levin
Journal:  Environ Health Perspect       Date:  2006-12       Impact factor: 9.031

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  112 in total

Review 1.  Recent advances in the epidemiologic investigation of risk factors for asthma: a review of the 2011 literature.

Authors:  Josep M Antó
Journal:  Curr Allergy Asthma Rep       Date:  2012-06       Impact factor: 4.806

2.  Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade.

Authors:  Emanuela Taioli; William K Oh; Yixuan Gong; Li Wang; Haocheng Yu; Naomi Alpert; Mitchell D Cohen; Colette Prophete; Lori Horton; Maureen Sisco; Sung-Hyun Park; Hyun-Wook Lee; Judith Zelikoff; Lung-Chi Chen; Dana Hashim; Mayte Suarez-Farinas; Michael J Donovan; Stuart A Aaronson; Matthew Galsky; Jun Zhu
Journal:  Mol Cancer Res       Date:  2019-06-20       Impact factor: 5.852

3.  The role of modifiable health-related behaviors in the association between PTSD and respiratory illness.

Authors:  Monika A Waszczuk; Camilo Ruggero; Kaiqiao Li; Benjamin J Luft; Roman Kotov
Journal:  Behav Res Ther       Date:  2018-11-01

4.  Mental health, long-term medication adherence, and the control of asthma symptoms among persons exposed to the WTC 9/11 disaster.

Authors:  Jennifer Brite; Stephen Friedman; Rafael E de la Hoz; Joan Reibman; James Cone
Journal:  J Asthma       Date:  2019-10-10       Impact factor: 2.515

5.  Cohort Profile: World Trade Center Health Program General Responder Cohort.

Authors:  Christopher R Dasaro; William L Holden; Karen D Berman; Michael A Crane; Julia R Kaplan; Roberto G Lucchini; Benjamin J Luft; Jacqueline M Moline; Susan L Teitelbaum; Usha S Tirunagari; Iris G Udasin; Jean H Weiner; Patrice A Zigrossi; Andrew C Todd
Journal:  Int J Epidemiol       Date:  2017-04-01       Impact factor: 7.196

Review 6.  Health effects of World Trade Center (WTC) Dust: An unprecedented disaster's inadequate risk management.

Authors:  Morton Lippmann; Mitchell D Cohen; Lung-Chi Chen
Journal:  Crit Rev Toxicol       Date:  2015-07       Impact factor: 5.635

Review 7.  Airway Disease in Rescue/Recovery Workers: Recent Findings from the World Trade Center Collapse.

Authors:  Krystal L Cleven; Mayris P Webber; Rachel Zeig-Owens; Kerry M Hena; David J Prezant
Journal:  Curr Allergy Asthma Rep       Date:  2017-01       Impact factor: 4.806

8.  Chest CT scan findings in World Trade Center workers.

Authors:  Rafael E de la Hoz; Jonathan Weber; Dongming Xu; John T Doucette; Xiaoyu Liu; Deborah A Carson; Juan C Celedón
Journal:  Arch Environ Occup Health       Date:  2018-05-09       Impact factor: 1.663

9.  Chernobyl cleanup workers from Estonia: follow-up for cancer incidence and mortality.

Authors:  Kaja Rahu; Anssi Auvinen; Timo Hakulinen; Mare Tekkel; Peter D Inskip; Evelyn J Bromet; John D Boice; Mati Rahu
Journal:  J Radiol Prot       Date:  2013-03-27       Impact factor: 1.394

10.  One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.

Authors:  Soo Jung Cho; Ghislaine C Echevarria; Sophia Kwon; Bushra Naveed; Edward J Schenck; Jun Tsukiji; William N Rom; David J Prezant; Anna Nolan; Michael D Weiden
Journal:  Respir Med       Date:  2013-11-13       Impact factor: 3.415

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