Ghalib A Bello1, Katherine A Ornstein2, Roberto G Lucchini1,3,4, William W Hung2,5, Fred C Ko2,5, Elena Colicino6, Emanuela Taioli7,8,9, Michael A Crane10, Andrew C Todd1. 1. Department of Environmental Medicine and Public Health, World Trade Center Health Program General Responder Data Center, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2. Brookdale Department of Geriatrics and Palliative Medicine, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3. 5450Florida International University, School of Public Health, Miami, FL, USA. 4. University of Brescia, Brescia, Italy. 5. James J. Peters VA Medical Center, New York, NY, USA. 6. Department of Environmental Medicine and Public Health, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7. Institute for Translational Epidemiology, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA. 8. Department of Population Health Science and Policy, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9. Department of Thoracic Surgery, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA. 10. Department of Environmental Medicine and Public Health, World Trade Center Health Program Clinical Center of Excellence at Mount Sinai, 5925Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract
Objectives: To develop and validate a clinical frailty index to characterize aging among responders to the 9/11 World Trade Center (WTC) attacks. Methods: This study was conducted on health monitoring data on a sample of 6197 responders. A clinical frailty index, WTC FI-Clinical, was developed according to the cumulative deficit model of frailty. The validity of the resulting index was assessed using all-cause mortality as an endpoint. Its association with various cohort characteristics was evaluated. Results: The sample's median age was 51 years. Thirty items were selected for inclusion in the index. It showed a strong correlation with age, as well as significant adjusted associations with mortality, 9/11 exposure severity, sex, race, pre-9/11 occupation, education, and smoking status. Discussion: The WTC FI-Clinical highlights effects of certain risk factors on aging within the 9/11 responder cohort. It will serve as a useful instrument for monitoring and tracking frailty within this cohort.
Objectives: To develop and validate a clinical frailty index to characterize aging among responders to the 9/11 World Trade Center (WTC) attacks. Methods: This study was conducted on health monitoring data on a sample of 6197 responders. A clinical frailty index, WTC FI-Clinical, was developed according to the cumulative deficit model of frailty. The validity of the resulting index was assessed using all-cause mortality as an endpoint. Its association with various cohort characteristics was evaluated. Results: The sample's median age was 51 years. Thirty items were selected for inclusion in the index. It showed a strong correlation with age, as well as significant adjusted associations with mortality, 9/11 exposure severity, sex, race, pre-9/11 occupation, education, and smoking status. Discussion: The WTC FI-Clinical highlights effects of certain risk factors on aging within the 9/11 responder cohort. It will serve as a useful instrument for monitoring and tracking frailty within this cohort.
Entities:
Keywords:
9/11 responders; World Trade Center cohort; frailty index
Authors: Oleg Zaslavsky; Barbara B Cochrane; Hilaire J Thompson; Nancy F Woods; Jerald R Herting; Andrea LaCroix Journal: Biol Res Nurs Date: 2012-10-18 Impact factor: 2.522
Authors: Ghalib A Bello; Susan L Teitelbaum; Roberto G Lucchini; Christopher R Dasaro; Moshe Shapiro; Julia R Kaplan; Michael A Crane; Denise J Harrison; Benjamin J Luft; Jacqueline M Moline; Iris G Udasin; Andrew C Todd Journal: Am J Ind Med Date: 2017-11-17 Impact factor: 2.214
Authors: Francisco José Tarazona-Santabalbina; Mari Carmen Gómez-Cabrera; Pilar Pérez-Ros; Francisco Miguel Martínez-Arnau; Helena Cabo; Konstantina Tsaparas; Andrea Salvador-Pascual; Leocadio Rodriguez-Mañas; José Viña Journal: J Am Med Dir Assoc Date: 2016-03-03 Impact factor: 4.669
Authors: Arnold Mitnitski; Joanna Collerton; Carmen Martin-Ruiz; Carol Jagger; Thomas von Zglinicki; Kenneth Rockwood; Thomas B L Kirkwood Journal: BMC Med Date: 2015-07-13 Impact factor: 8.775
Authors: Sean A P Clouston; Erica D Diminich; Roman Kotov; Robert H Pietrzak; Marcus Richards; Avron Spiro; Yael Deri; Melissa Carr; Xiaohua Yang; Sam Gandy; Mary Sano; Evelyn J Bromet; Benjamin J Luft Journal: Alzheimers Dement (Amst) Date: 2019-09-06
Authors: Moshe Z Shapiro; Sylvan R Wallenstein; Christopher R Dasaro; Roberto G Lucchini; Henry S Sacks; Susan L Teitelbaum; Erin S Thanik; Michael A Crane; Denise J Harrison; Benjamin J Luft; Jacqueline M Moline; Iris G Udasin; Andrew C Todd Journal: JNCI Cancer Spectr Date: 2019-11-06
Authors: Matthew J Mears; David M Aslaner; Chad T Barson; Mitchell D Cohen; Matthew W Gorr; Loren E Wold Journal: Life Sci Date: 2021-11-14 Impact factor: 5.037