Amandine Coum1,2, Lobna Ouldamer3,4,5, Fanny Noury6,7, Laurent Barantin5,8, Aymeric Saint-Hilaire9, Anne Vilde9, Philippe Bougnoux4,5,10, Giulio Gambarota6,7. 1. Université de Rennes 1, 35000, Rennes, France. amandine.coum@gmail.com. 2. LTSI, INSERM, UMR 1099, 35000, Rennes, France. amandine.coum@gmail.com. 3. Département de Gynécologie, CHRU de Tours, 37044, Tours, France. 4. INSERM U1069, 37044, Tours, France. 5. Université François-Rabelais, 37044, Tours, France. 6. Université de Rennes 1, 35000, Rennes, France. 7. LTSI, INSERM, UMR 1099, 35000, Rennes, France. 8. INSERM U930, 37044, Tours, France. 9. Département de Radiologie, CHRU de Tours, 37044, Tours, France. 10. Département d'Oncologie, CHRU de Tours, 37044, Tours, France.
Abstract
OBJECTIVE: To evaluate the feasibility of in vivo measurement of the fatty acid (FA) composition of breast adipose tissue by MRS on a clinical platform. MATERIAL AND METHODS: MRS experiments were performed at 3 T, using a STEAM sequence, on 25 patients diagnosed with breast cancer. MR spectra, acquired on healthy breast tissue, were analysed with the LCModel. RESULTS: The measured values of the saturated fatty acid (SFA), mono-unsaturated fatty acid (MUFA) and poly-unsaturated fatty acid (PUFA) fractions were 23.8 ± 7.1%, 55.4 ± 6.8% and 20.8 ± 4.4%, respectively. The values of SFA, MUFA and PUFA observed in the current study are in the same range as those found in two previous studies performed at 7 T. CONCLUSION: The results of the current study show that it is possible to quantify the fatty acid composition of breast tissue in vivo in a clinical setting (3 T).
OBJECTIVE: To evaluate the feasibility of in vivo measurement of the fatty acid (FA) composition of breast adipose tissue by MRS on a clinical platform. MATERIAL AND METHODS:MRS experiments were performed at 3 T, using a STEAM sequence, on 25 patients diagnosed with breast cancer. MR spectra, acquired on healthy breast tissue, were analysed with the LCModel. RESULTS: The measured values of the saturated fatty acid (SFA), mono-unsaturated fatty acid (MUFA) and poly-unsaturated fatty acid (PUFA) fractions were 23.8 ± 7.1%, 55.4 ± 6.8% and 20.8 ± 4.4%, respectively. The values of SFA, MUFA and PUFA observed in the current study are in the same range as those found in two previous studies performed at 7 T. CONCLUSION: The results of the current study show that it is possible to quantify the fatty acid composition of breast tissue in vivo in a clinical setting (3 T).
Entities:
Keywords:
Breast cancer; Fatty acid; MRS; Quantification
Authors: Ivan E Dimitrov; Deborah Douglas; Jimin Ren; Nadine B Smith; Andrew G Webb; A Dean Sherry; Craig R Malloy Journal: Magn Reson Med Date: 2011-06-07 Impact factor: 4.668
Authors: K A Kvistad; I J Bakken; I S Gribbestad; B Ehrnholm; S Lundgren; H E Fjøsne; O Haraldseth Journal: J Magn Reson Imaging Date: 1999-08 Impact factor: 4.813
Authors: N R Jagannathan; M Kumar; V Seenu; O Coshic; S N Dwivedi; P K Julka; A Srivastava; G K Rath Journal: Br J Cancer Date: 2001-04-20 Impact factor: 7.640
Authors: Dianning He; Devkumar Mustafi; Xiaobing Fan; Sully Fernandez; Erica Markiewicz; Marta Zamora; Jeffrey Mueller; Joseph R Sachleben; Matthew J Brady; Suzanne D Conzen; Gregory S Karczmar Journal: PLoS One Date: 2018-01-11 Impact factor: 3.240
Authors: Vasiliki Mallikourti; Sai Man Cheung; Tanja Gagliardi; Nicholas Senn; Yazan Masannat; Trevor McGoldrick; Ravi Sharma; Steven D Heys; Jiabao He Journal: Sci Rep Date: 2020-11-18 Impact factor: 4.379