Rebecca G Clifton1, Mary Evans2, Alison G Cahill3, Paul W Franks4,5, Dympna Gallagher6, Suzanne Phelan7, Jeremy Pomeroy8, Leanne M Redman9, Linda Van Horn10. 1. The George Washington University Biostatistics Center, Washington, DC, USA. 2. The National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA. 3. Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA. 4. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Malmö, Sweden. 5. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. 6. Department of Medicine, St. Luke's-Roosevelt Hospital and Columbia University, New York, New York, USA. 7. Department of Kinesiology, California Polytechnic State University, San Luis Obispo, California, USA. 8. Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA. 9. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. 10. Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Abstract
OBJECTIVE: The Lifestyle Interventions for Expectant Moms (LIFE-Moms) Consortium is designed to determine, in pregnant women with overweight or obesity, whether various behavioral and lifestyle interventions reduce excessive gestational weight gain (GWG) and subsequent adverse maternal and neonatal outcomes and obesity in offspring. The design and planning process of the LIFE-Moms Consortium is described. METHODS: The LIFE-Moms Consortium is a collaboration among seven clinical centers, a Research Coordinating Unit, and the NIH designed to support each clinical center's conduct of a separate trial of a unique intervention. Specific common measures, procedures, and eligibility criteria are consistent across the seven trials allowing data to be combined in exploratory analyses and/or compared readily. RESULTS: Numerous committees and working groups were created to define common measures and outcomes during pregnancy and through 1 year postpartum, develop Consortium policies, and oversee progress of the trials. The primary outcome for the Consortium is excessive GWG. Secondary outcomes include maternal, neonatal, and infant anthropometric measures, physical activity, sleep, and complications of pregnancy and delivery. CONCLUSIONS: A multi-center consortium of independent, lifestyle interventions with common measures and outcomes may enhance the ability to identify promising interventions for improving outcomes in pregnant women and their offspring.
OBJECTIVE: The Lifestyle Interventions for Expectant Moms (LIFE-Moms) Consortium is designed to determine, in pregnant women with overweight or obesity, whether various behavioral and lifestyle interventions reduce excessive gestational weight gain (GWG) and subsequent adverse maternal and neonatal outcomes and obesity in offspring. The design and planning process of the LIFE-Moms Consortium is described. METHODS: The LIFE-Moms Consortium is a collaboration among seven clinical centers, a Research Coordinating Unit, and the NIH designed to support each clinical center's conduct of a separate trial of a unique intervention. Specific common measures, procedures, and eligibility criteria are consistent across the seven trials allowing data to be combined in exploratory analyses and/or compared readily. RESULTS: Numerous committees and working groups were created to define common measures and outcomes during pregnancy and through 1 year postpartum, develop Consortium policies, and oversee progress of the trials. The primary outcome for the Consortium is excessive GWG. Secondary outcomes include maternal, neonatal, and infant anthropometric measures, physical activity, sleep, and complications of pregnancy and delivery. CONCLUSIONS: A multi-center consortium of independent, lifestyle interventions with common measures and outcomes may enhance the ability to identify promising interventions for improving outcomes in pregnant women and their offspring.
Authors: Mark Christopher Alanis; William H Goodnight; Elizabeth G Hill; Christopher J Robinson; Margaret S Villers; Donna D Johnson Journal: Acta Obstet Gynecol Scand Date: 2010-07 Impact factor: 3.636
Authors: Leslie A Lytle; Laura P Svetkey; Kevin Patrick; Steven H Belle; I Diana Fernandez; John M Jakicic; Karen C Johnson; Christine M Olson; Deborah F Tate; Rena Wing; Catherine M Loria Journal: Transl Behav Med Date: 2014-09 Impact factor: 3.046
Authors: B C Brost; R L Goldenberg; B M Mercer; J D Iams; P J Meis; A H Moawad; R B Newman; M Miodovnik; S N Caritis; G R Thurnau; S F Bottoms; A Das; D McNellis Journal: Am J Obstet Gynecol Date: 1997-08 Impact factor: 8.661
Authors: Israel Hendler; Robert L Goldenberg; Brian M Mercer; Jay D Iams; Paul J Meis; Atef H Moawad; Cora A MacPherson; Steve N Caritis; Menachem Miodovnik; Kate M Menard; Gary R Thurnau; Yoram Sorokin Journal: Am J Obstet Gynecol Date: 2005-03 Impact factor: 8.661
Authors: Shelly M Asbee; Todd R Jenkins; Jennifer R Butler; John White; Mollie Elliot; Allyson Rutledge Journal: Obstet Gynecol Date: 2009-02 Impact factor: 7.661
Authors: Jodie M Dodd; Deborah Turnbull; Andrew J McPhee; Andrea R Deussen; Rosalie M Grivell; Lisa N Yelland; Caroline A Crowther; Gary Wittert; Julie A Owens; Jeffrey S Robinson Journal: BMJ Date: 2014-02-10
Authors: Suzanne Phelan; Rena R Wing; Anna Brannen; Angelica McHugh; Todd A Hagobian; Andrew Schaffner; Elissa Jelalian; Chantelle N Hart; Theresa O Scholl; Karen Munoz-Christian; Elaine Yin; Maureen G Phipps; Sarah Keadle; Barbara Abrams Journal: Am J Clin Nutr Date: 2018-02-01 Impact factor: 7.045
Authors: Sharon J Herring; Jessica J Albert; Niesha Darden; Brooke Bailer; Jane Cruice; Sarmina Hassan; Gary G Bennett; Laura Goetzl; Daohai Yu; Linda M Kilby; Gary D Foster Journal: Contemp Clin Trials Date: 2019-08-07 Impact factor: 2.226
Authors: S Sonia Arteaga; Layla Esposito; Stavroula K Osganian; Charlotte A Pratt; Jill Reedy; Deborah Young-Hyman Journal: Transl Behav Med Date: 2018-11-21 Impact factor: 3.046
Authors: Adam K Lewkowitz; Julia D López; Richard I Stein; Janine S Rhoades; Rosa C Schulz; Candice L Woolfolk; George A Macones; Debra Haire-Joshu; Alison G Cahill Journal: Breastfeed Med Date: 2018-06-18 Impact factor: 1.817
Authors: Margaret C Fahey; G Wayne Talcott; Callie M Cox Bauer; Zoran Bursac; Leslie Gladney; Marion E Hare; Jean Harvey; Melissa Little; Deirdre McCullough; Ann S Hryshko-Mullen; Robert C Klesges; Mehmet Kocak; Teresa M Waters; Rebecca A Krukowski Journal: Contemp Clin Trials Date: 2018-10-04 Impact factor: 2.226