Literature DB >> 26692922

H19 derived microRNA-675 regulates cell proliferation and migration through CDK6 in glioma.

Chao Li1, Bingxi Lei2, Shuaibin Huang2, Meiguang Zheng2, Zhenghao Liu2, Zhongjun Li2, Yuefei Deng2.   

Abstract

The long non-coding RNA (LncRNA) H19 is one of the most highly abundant and conserved transcripts involved in the mammalian development and tumorigenesis. H19 is expressed in both embryonic cells and tumor cells, but its physical and pathological functions still need to be further studied. Our results showed that microRNA-675, a microRNA in the first exon of H19, expressed in glioma. Over-expression of microRNA-675 in a range of glioma cell lines resulted in their immoderate proliferation and migration. In addition, H19 derived microRNA-675 was down-regulated in the glioma, and CDK6, a pivotal regulator in cell cycle, was a target of microRNA-675. The survival of glioma patients with low CDK6 expression significantly increased as compared to patients with high CDK6 expression. Moreover, the CDK6 expression was inversely correlated with microRNA-675 expression in the glioma. Our results suggest that H19 derived microRNA-675 may regulate giloma cell proliferation and migration through CDK6, and predict a poor prognosis of glioma patients.

Entities:  

Keywords:  H19; glioma; microRNA-675

Year:  2015        PMID： 26692922      PMCID： PMC4656755     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  50 in total

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Journal:  Epigenetics       Date:  2012-02       Impact factor: 4.528

2.  A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

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3.  miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase.

Authors:  Kun Wang; Xuan Wang; Jian Zou; Anling Zhang; Yingfeng Wan; Peiyu Pu; Zhengfei Song; Cong Qian; Yili Chen; Shuxu Yang; Yirong Wang
Journal:  Neuro Oncol       Date:  2013-02-14       Impact factor: 12.300

4.  Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.

Authors:  Laura H Tang; Tanupriya Contractor; Richard Clausen; David S Klimstra; Yi-Chieh Nancy Du; Peter J Allen; Murray F Brennan; Arnold J Levine; Chris R Harris
Journal:  Clin Cancer Res       Date:  2012-07-03       Impact factor: 12.531

5.  cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain.

Authors:  M J Grossel; G L Baker; P W Hinds
Journal:  J Biol Chem       Date:  1999-10-15       Impact factor: 5.157

6.  The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.

Authors:  Sabine Paternot; Bianca Colleoni; Xavier Bisteau; Pierre P Roger
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

7.  Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.

Authors:  L Yan; J Zhou; Y Gao; S Ghazal; L Lu; S Bellone; Y Yang; N Liu; X Zhao; A D Santin; H Taylor; Y Huang
Journal:  Oncogene       Date:  2014-08-04       Impact factor: 9.867

8.  Translocation t(2;7)(p11;q21) associated with the CDK6/IGK rearrangement is a rare but recurrent abnormality in B-cell lymphoproliferative malignancies.

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Journal:  Cancer Genet       Date:  2014-02-28

9.  Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia.

Authors:  Guo-Lian Ding; Fang-Fang Wang; Jing Shu; Shen Tian; Ying Jiang; Dan Zhang; Ning Wang; Qiong Luo; Yu Zhang; Fan Jin; Peter C K Leung; Jian-Zhong Sheng; He-Feng Huang
Journal:  Diabetes       Date:  2012-03-23       Impact factor: 9.461

10.  Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas.

Authors:  Chencheng Xie; Huarui Lu; Alice Nomura; Eric Allan Hanse; Colleen Lynn Forster; Josh Berken Parker; Michael Andrew Linden; Chris Karasch; Timothy Curtis Hallstrom
Journal:  Mol Cancer       Date:  2015-04-24       Impact factor: 27.401
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  25 in total

1.  LncRNA LINC00152 promoted glioblastoma progression through targeting the miR-107 expression.

Authors:  Xinzhi Liu; Yimamu Yidayitula; Heng Zhao; Yi Luo; Xiaoqiang Ma; Minhua Xu
Journal:  Environ Sci Pollut Res Int       Date:  2018-04-18       Impact factor: 4.223

2.  The evaluation expression of non-coding RNAs in response to HSV-G47∆ oncolytic virus infection in glioblastoma multiforme cancer stem cells.

Authors:  Reza Vazifehmand; Dhuha Saeed Ali; Zulkefley Othman; De-Ming Chau; Johnson Stanslas; Mehdi Shafa; Zamberi Sekawi
Journal:  J Neurovirol       Date:  2022-08-11       Impact factor: 3.739

Review 3.  A critical overview of long non-coding RNA in glioma etiology 2016: an update.

Authors:  Yuan-Feng Gao; Zhi-Bin Wang; Tao Zhu; Chen-Xue Mao; Xiao-Yuan Mao; Ling Li; Ji-Ye Yin; Hong-Hao Zhou; Zhao-Qian Liu
Journal:  Tumour Biol       Date:  2016-09-15

Review 4.  Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets.

Authors:  Sung-Hyun Kim; Key-Hwan Lim; Sumin Yang; Jae-Yeol Joo
Journal:  J Hematol Oncol       Date:  2021-05-12       Impact factor: 17.388

5.  Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing.

Authors:  C Voellenkle; J M Garcia-Manteiga; S Pedrotti; A Perfetti; I De Toma; D Da Silva; B Maimone; S Greco; P Fasanaro; P Creo; G Zaccagnini; C Gaetano; F Martelli
Journal:  Sci Rep       Date:  2016-04-11       Impact factor: 4.379

6.  Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features.

Authors:  Yang Lin; Lijian Xu; Wei Wei; Xiaohui Zhang; Rongchao Ying
Journal:  Biomed Res Int       Date:  2016-09-21       Impact factor: 3.411

Review 7.  Long non-coding RNA in glioma: signaling pathways.

Authors:  Jia Shi; Bo Dong; Jiachao Cao; Yumin Mao; Wei Guan; Ya Peng; Suinuan Wang
Journal:  Oncotarget       Date:  2017-04-18

Review 8.  An Insight into the Increasing Role of LncRNAs in the Pathogenesis of Gliomas.

Authors:  Yuanliang Yan; Zhijie Xu; Zhi Li; Lunquan Sun; Zhicheng Gong
Journal:  Front Mol Neurosci       Date:  2017-02-28       Impact factor: 5.639

9.  LncRNA H19 Upregulation Participates in the Response of Glioma Cells to Radiation.

Authors:  Yanbei Kuang; Zhitong Bing; Xiaodong Jin; Qiang Li
Journal:  Biomed Res Int       Date:  2021-05-31       Impact factor: 3.411

10.  The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter.

Authors:  Barbara Fazi; Sabrina Garbo; Nicola Toschi; Annunziato Mangiola; Malinska Lombari; Daria Sicari; Cecilia Battistelli; Silvia Galardi; Alessandro Michienzi; Gianluca Trevisi; Rona Harari-Steinfeld; Carla Cicchini; Silvia Anna Ciafrè
Journal:  Oncotarget       Date:  2018-02-14
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