| Literature DB >> 20385361 |
Ruihuan Chen1, Merry C Nishimura, Stephanie M Bumbaca, Samir Kharbanda, William F Forrest, Ian M Kasman, Joan M Greve, Robert H Soriano, Laurie L Gilmour, Celina Sanchez Rivers, Zora Modrusan, Serban Nacu, Steve Guerrero, Kyle A Edgar, Jeffrey J Wallin, Katrin Lamszus, Manfred Westphal, Susanne Heim, C David James, Scott R VandenBerg, Joseph F Costello, Scott Moorefield, Cynthia J Cowdrey, Michael Prados, Heidi S Phillips.
Abstract
The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20385361 DOI： 10.1016/j.ccr.2009.12.049
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743