| Literature DB >> 27629290 |
Yuan-Feng Gao1,2,3, Zhi-Bin Wang1,2,3, Tao Zhu1,2,3, Chen-Xue Mao1,2,3, Xiao-Yuan Mao1,2,3, Ling Li1,2,3, Ji-Ye Yin1,2,3, Hong-Hao Zhou1,2,3, Zhao-Qian Liu4,5,6.
Abstract
With the development of whole genome and transcriptome sequencing technologies, a growing body of long non-coding RNAs (lncRNAs) has been identified and is receiving increasing attention. LncRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases, specifically glioma. It has been established that lncRNAs are differently expressed in the central nervous system and may play a vital role in glioma. As of June 2016, 20 lncRNAs have been identified that may play a role in glioma pathogenesis. Investigation into the role of lncRNAs in glioma may help to identify potential biomarkers which can improve the diagnosis and treatment of glioma. In this paper, we review current understanding of the function of lncRNAs in glioma initiation and progression.Entities:
Keywords: Functional roles; Glioma; Potential biomarkers and therapeutic targets; lncRNAs
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Year: 2016 PMID： 27629290 DOI： 10.1007/s13277-016-5307-4
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283