Literature DB >> 25130507

Ivermectin: panacea for resource-poor communities?

Satoshi Omura1, Andy Crump2.   

Abstract

The 2014 Gairdner Global Health Award was conferred for discovery of the unique microorganism that is the sole source of the endectocidal avermectins, and the Public sector/Private sector Partnership that developed innovative biopharmaceuticals with immeasurably beneficial impact on public health worldwide. Ivermectin is already labelled a 'wonder drug', essential for campaigns to eliminate two disfiguring and devastating tropical diseases. New uses for it are identified regularly, including possible antibacterial, antiviral, and anticancer potential. Hundreds of millions of people are taking ivermectin to combat various diseases and afflictions, and mass administration of ivermectin in polyparasitised poor communities around the world is increasingly recognised as a mechanism to easily and cost-effectively improve overall health and quality of life for everyone.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  endectocide; global public health; ivermectin; onchocerciasis; wonder drug

Mesh:

Substances:

Year:  2014        PMID: 25130507     DOI: 10.1016/j.pt.2014.07.005

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN: 1471-4922


  42 in total

1.  Fate of ivermectin in the terrestrial and aquatic environment: mobility, degradation, and toxicity towards Daphnia similis.

Authors:  Susanne Rath; Leandro Alves Pereira; Sandra Maria Dal Bosco; Milena Guedes Maniero; Anne Hélène Fostier; José Roberto Guimarães
Journal:  Environ Sci Pollut Res Int       Date:  2015-11-18       Impact factor: 4.223

Review 2.  Taxonomy, Physiology, and Natural Products of Actinobacteria.

Authors:  Essaid Ait Barka; Parul Vatsa; Lisa Sanchez; Nathalie Gaveau-Vaillant; Cedric Jacquard; Jan P Meier-Kolthoff; Hans-Peter Klenk; Christophe Clément; Yder Ouhdouch; Gilles P van Wezel
Journal:  Microbiol Mol Biol Rev       Date:  2015-11-25       Impact factor: 11.056

3.  Ivermectin Impairs the Development of Sexual and Asexual Stages of Plasmodium falciparum In Vitro.

Authors:  Lais Pessanha de Carvalho; Thaisa Lucas Sandri; Edésio José Tenório de Melo; Rolf Fendel; Peter G Kremsner; Benjamin Mordmüller; Jana Held
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

4.  Ivermectin and COVID-19: Keeping Rigor in Times of Urgency.

Authors:  Carlos Chaccour; Felix Hammann; Santiago Ramón-García; N Regina Rabinovich
Journal:  Am J Trop Med Hyg       Date:  2020-06       Impact factor: 2.345

5.  Avermectin B1a production in Streptomyces avermitilis is enhanced by engineering aveC and precursor supply genes.

Authors:  Yi Hao; Yanting You; Zhi Chen; Jilun Li; Gang Liu; Ying Wen
Journal:  Appl Microbiol Biotechnol       Date:  2022-03-08       Impact factor: 4.813

6.  A New Golden Age of Natural Products Drug Discovery.

Authors:  Ben Shen
Journal:  Cell       Date:  2015-12-03       Impact factor: 41.582

Review 7.  Heartworm disease - Overview, intervention, and industry perspective.

Authors:  Sandra Noack; John Harrington; Douglas S Carithers; Ronald Kaminsky; Paul M Selzer
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2021-04-27       Impact factor: 4.077

8.  Screening for an ivermectin slow-release formulation suitable for malaria vector control.

Authors:  Carlos Chaccour; Ángel Barrio; Ana Gloria Gil Royo; Diego Martinez Urbistondo; Hannah Slater; Felix Hammann; Jose Luis Del Pozo
Journal:  Malar J       Date:  2015-03-05       Impact factor: 2.979

9.  Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase.

Authors:  Ji Zhang; Yi-Jun Yan; Jing An; Sheng-Xiong Huang; Xiang-Jing Wang; Wen-Sheng Xiang
Journal:  Microb Cell Fact       Date:  2015-09-24       Impact factor: 5.328

10.  Effect of ivermectin on the larvae of Anopheles gambiae and Culex quinquefasciatus.

Authors:  Yahya A Derua; Bernard B Malongo; Paul E Simonsen
Journal:  Parasit Vectors       Date:  2016-03-08       Impact factor: 3.876

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