Literature DB >> 30146919

How to rekindle drug discovery process through integrative therapeutic targeting?

Ashok Vaidya1, Anuradha Roy2, Rathnam Chaguturu3.   

Abstract

Entities:  

Keywords:  Artificial intelligence; GWAS; drug targets; gene editing; intellectual property; observational therapeutics; open innovation; phenotypic screening; reverse pharmacology; traditional medicine

Mesh：

Year:  2018        PMID： 30146919      PMCID： PMC6436386          DOI： 10.1080/17460441.2018.1514010

Source DB:  PubMed          Journal:  Expert Opin Drug Discov        ISSN： 1746-0441            Impact factor:   6.098


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  16 in total

Review 1.  Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting.

Authors:  Georgina S Butler; Christopher M Overall
Journal:  Nat Rev Drug Discov       Date:  2009-12       Impact factor: 84.694

Review 2.  Developing predictive assays: the phenotypic screening "rule of 3".

Authors:  Fabien Vincent; Paula Loria; Marko Pregel; Robert Stanton; Linda Kitching; Karl Nocka; Regis Doyonnas; Claire Steppan; Adam Gilbert; Thomas Schroeter; Marie-Claire Peakman
Journal:  Sci Transl Med       Date:  2015-06-24       Impact factor: 17.956

3.  Academia-pharma partnerships for novel drug discovery: essential or nice to have?

Authors:  Michelle Palmer; Rathnam Chaguturu
Journal:  Expert Opin Drug Discov       Date:  2017-04-17       Impact factor: 6.098

Review 4.  The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.

Authors:  Ricardo Titze-de-Almeida; Catherine David; Simoneide Souza Titze-de-Almeida
Journal:  Pharm Res       Date:  2017-04-07       Impact factor: 4.200

Review 5.  Cornerstones of CRISPR-Cas in drug discovery and therapy.

Authors:  Christof Fellmann; Benjamin G Gowen; Pei-Chun Lin; Jennifer A Doudna; Jacob E Corn
Journal:  Nat Rev Drug Discov       Date:  2016-12-23       Impact factor: 84.694

Review 6.  Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds.

Authors:  Ammad Ahmad Farooqi; Nishil N Desai; Muhammad Zahid Qureshi; Daniele Rubert Nogueira Librelotto; Maria Luisa Gasparri; Anupam Bishayee; Seyed Mohammad Nabavi; Valeria Curti; Maria Daglia
Journal:  Biotechnol Adv       Date:  2017-12-14       Impact factor: 14.227

Review 7.  Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery.

Authors:  Shibing Tang; Min Xie; Nan Cao; Sheng Ding
Journal:  J Med Chem       Date:  2015-09-04       Impact factor: 7.446

Review 8.  The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:  Alexandra B Keenan; Sherry L Jenkins; Kathleen M Jagodnik; Simon Koplev; Edward He; Denis Torre; Zichen Wang; Anders B Dohlman; Moshe C Silverstein; Alexander Lachmann; Maxim V Kuleshov; Avi Ma'ayan; Vasileios Stathias; Raymond Terryn; Daniel Cooper; Michele Forlin; Amar Koleti; Dusica Vidovic; Caty Chung; Stephan C Schürer; Jouzas Vasiliauskas; Marcin Pilarczyk; Behrouz Shamsaei; Mehdi Fazel; Yan Ren; Wen Niu; Nicholas A Clark; Shana White; Naim Mahi; Lixia Zhang; Michal Kouril; John F Reichard; Siva Sivaganesan; Mario Medvedovic; Jaroslaw Meller; Rick J Koch; Marc R Birtwistle; Ravi Iyengar; Eric A Sobie; Evren U Azeloglu; Julia Kaye; Jeannette Osterloh; Kelly Haston; Jaslin Kalra; Steve Finkbiener; Jonathan Li; Pamela Milani; Miriam Adam; Renan Escalante-Chong; Karen Sachs; Alex Lenail; Divya Ramamoorthy; Ernest Fraenkel; Gavin Daigle; Uzma Hussain; Alyssa Coye; Jeffrey Rothstein; Dhruv Sareen; Loren Ornelas; Maria Banuelos; Berhan Mandefro; Ritchie Ho; Clive N Svendsen; Ryan G Lim; Jennifer Stocksdale; Malcolm S Casale; Terri G Thompson; Jie Wu; Leslie M Thompson; Victoria Dardov; Vidya Venkatraman; Andrea Matlock; Jennifer E Van Eyk; Jacob D Jaffe; Malvina Papanastasiou; Aravind Subramanian; Todd R Golub; Sean D Erickson; Mohammad Fallahi-Sichani; Marc Hafner; Nathanael S Gray; Jia-Ren Lin; Caitlin E Mills; Jeremy L Muhlich; Mario Niepel; Caroline E Shamu; Elizabeth H Williams; David Wrobel; Peter K Sorger; Laura M Heiser; Joe W Gray; James E Korkola; Gordon B Mills; Mark LaBarge; Heidi S Feiler; Mark A Dane; Elmar Bucher; Michel Nederlof; Damir Sudar; Sean Gross; David F Kilburn; Rebecca Smith; Kaylyn Devlin; Ron Margolis; Leslie Derr; Albert Lee; Ajay Pillai
Journal:  Cell Syst       Date:  2017-11-29       Impact factor: 10.304

9.  Sustainable data and metadata management at the BD2K-LINCS Data Coordination and Integration Center.

Authors:  Vasileios Stathias; Amar Koleti; Dušica Vidović; Daniel J Cooper; Kathleen M Jagodnik; Raymond Terryn; Michele Forlin; Caty Chung; Denis Torre; Nagi Ayad; Mario Medvedovic; Avi Ma'ayan; Ajay Pillai; Stephan C Schürer
Journal:  Sci Data       Date:  2018-06-19       Impact factor: 6.444

Review 10.  Opportunities and obstacles for deep learning in biology and medicine.

Authors:  Travers Ching; Daniel S Himmelstein; Brett K Beaulieu-Jones; Alexandr A Kalinin; Brian T Do; Gregory P Way; Enrico Ferrero; Paul-Michael Agapow; Michael Zietz; Michael M Hoffman; Wei Xie; Gail L Rosen; Benjamin J Lengerich; Johnny Israeli; Jack Lanchantin; Stephen Woloszynek; Anne E Carpenter; Avanti Shrikumar; Jinbo Xu; Evan M Cofer; Christopher A Lavender; Srinivas C Turaga; Amr M Alexandari; Zhiyong Lu; David J Harris; Dave DeCaprio; Yanjun Qi; Anshul Kundaje; Yifan Peng; Laura K Wiley; Marwin H S Segler; Simina M Boca; S Joshua Swamidass; Austin Huang; Anthony Gitter; Casey S Greene
Journal:  J R Soc Interface       Date:  2018-04       Impact factor: 4.293
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  1 in total

1.  The Resurrection of Phenotypic Drug Discovery.

Authors:  Wayne E Childers; Khaled M Elokely; Magid Abou-Gharbia
Journal:  ACS Med Chem Lett       Date:  2020-03-06       Impact factor: 4.345
  1 in total

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