| Literature DB >> 26607379 |
Mohamed S Abdelfattah1,2, Naoki Ishikawa1, Utpal K Karmakar1, Masami Ishibashi3.
Abstract
One new alkyl sulfonic acid derivative, sulfotanone (1), and the known panosialin wA (2) were isolated from the methanolic extract of mycelium of Streptomyces sp. 11694. The structure of the new compound (1) was established by a combination of spectroscopic techniques, including HRESIMS, IR, 1D and 2D NMR measurements. Compound 1 (40 µM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance in human gastric adenocarcinoma cell lines.Entities:
Keywords: Actinomycetes; Spectroscopy; Sulfonic acid; TRAIL
Mesh:
Substances:
Year: 2015 PMID: 26607379 DOI: 10.1007/s11418-015-0951-3
Source DB: PubMed Journal: J Nat Med ISSN: 1340-3443 Impact factor: 2.343