Literature DB >> 21090727

Izumiphenazines A-C: isolation and structure elucidation of phenazine derivatives from Streptomyces sp. IFM 11204.

Mohamed S Abdelfattah1, Toume Kazufumi, Masami Ishibashi.   

Abstract

Three new phenazine derivatives, named izumiphenazines A-C (1-3), and the known phenazine-1,6-dicarboxylic acid (4) were isolated from Streptomyces sp. IFM 11204. The structures of the isolated compounds were elucidated by means of spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. Compounds 1-3 were evaluated for their activity in overcoming TRAIL (TNF-related apoptosis-inducing ligand) resistance in human gastric adenocarcinoma cells. Compounds 2 (30 μM) and 3 (20 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant AGS cells.

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Year:  2010        PMID： 21090727     DOI： 10.1021/np100400t

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

1.  Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.

Authors:  Rajkumar Rajule; Vashti C Bryant; Hernando Lopez; Xu Luo; Amarnath Natarajan
Journal:  Bioorg Med Chem       Date:  2012-02-16       Impact factor: 3.641

2.  Diastaphenazine, a new dimeric phenazine from an endophytic Streptomyces diastaticus subsp. ardesiacus.

Authors:  Yiqing Li; Li Han; He Rong; Liya Li; Lixing Zhao; Longxia Wu; Lihua Xu; Yi Jiang; Xueshi Huang
Journal:  J Antibiot (Tokyo)       Date:  2014-09-17       Impact factor: 2.649

3.  Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.

Authors:  Xiachang Wang; Muhammad Abbas; Yinan Zhang; Sherif I Elshahawi; Larissa V Ponomareva; Zheng Cui; Steven G Van Lanen; Imran Sajid; S Randal Voss; Khaled A Shaaban; Jon S Thorson
Journal:  J Nat Prod       Date:  2019-05-22       Impact factor: 4.050

4.  Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

Authors:  Changsheng Wu; Gilles P van Wezel; Young Hae Choi
Journal:  J Antibiot (Tokyo)       Date:  2015-02-18       Impact factor: 2.649

5.  Sulfotanone, a new alkyl sulfonic acid derivative from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activity.

Authors:  Mohamed S Abdelfattah; Naoki Ishikawa; Utpal K Karmakar; Masami Ishibashi
Journal:  J Nat Med       Date:  2015-11-25       Impact factor: 2.343

6.  New phenazine analogues from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activities.

Authors:  Mohamed S Abdelfattah; Naoki Ishikawa; Utpal K Karmakar; Kazuki Yamaku; Masami Ishibashi
Journal:  J Antibiot (Tokyo)       Date:  2015-12-16       Impact factor: 2.649

7.  Chromomycins A2 and A3 from marine actinomycetes with TRAIL resistance-overcoming and Wnt signal inhibitory activities.

Authors:  Kazufumi Toume; Kentaro Tsukahara; Hanako Ito; Midori A Arai; Masami Ishibashi
Journal:  Mar Drugs       Date:  2014-06-05       Impact factor: 5.118

8.  The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in Streptomyces.

Authors:  Ramón I Santamaría; Laura Sevillano; Jesús Martín; Olga Genilloud; Ignacio González; Margarita Díaz
Journal:  Front Microbiol       Date:  2018-11-16       Impact factor: 5.640

9.  Isolation and structure elucidation of phenazine derivative from Streptomyces sp. strain UICC B-92 isolated from Neesia altissima (Malvaceae).

Authors:  Rina Hidayati Pratiwi; Iman Hidayat; Muhammad Hanafi; Wibowo Mangunwardoyo
Journal:  Iran J Microbiol       Date:  2020-04

10.  Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.

Authors:  Aida Sarmiento-Vizcaíno; Julia Espadas; Jesús Martín; Alfredo F Braña; Fernando Reyes; Luis A García; Gloria Blanco
Journal:  Front Microbiol       Date:  2018-04-23       Impact factor: 5.640
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