Literature DB >> 26594089

Wideband Electrically-Pumped 1050 nm MEMS-Tunable VCSEL for Ophthalmic Imaging.

Demis D John1, Christopher B Burgner1, Benjamin Potsaid1, Martin E Robertson1, Byung Kun Lee1, Woo Jhon Choi1, Alex E Cable1, James G Fujimoto1, Vijaysekhar Jayaraman1.   

Abstract

In this paper, we present a 1050 nm electrically-pumped micro-electro-mechanically-tunable vertical-cavity-surface-emitting-laser (MEMS-VCSEL) with a record dynamic tuning bandwidth of 63.8 nm, suitable for swept source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost & complexity relative to previously demonstrated optically pumped devices by obviating the need for a pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging with the electrically-pumped MEMS-VCSEL at a 400 kHz axial scan rate for wide field imaging of the in vivo human retina over a 12 mm × 12 mm field and for OCT angiography of the macula over 6 mm × 6 mm & 3 mm × 3 mm fields to show retinal vasculature and capillary structure near the fovea. These results demonstrate the feasibility of electrically pumped MEMS-VCSELs in ophthalmic instrumentation, the largest clinical application of OCT. In addition, we estimate that the 3 dB coherence length in air is 225 meters ± 51 meters, far greater than required for ophthalmic SS-OCT and suggestive of other distance ranging applications.

Entities:  

Keywords:  Medical Imaging; Micro and Nano Opto-Electro-Mechanical Systems (MOEMS); Optical Coherence Tomography; Semiconductor Lasers; Tunable Lasers

Year:  2015        PMID: 26594089      PMCID: PMC4651169          DOI: 10.1109/JLT.2015.2397860

Source DB:  PubMed          Journal:  J Lightwave Technol        ISSN: 0733-8724            Impact factor:   4.142


  11 in total

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3.  Optical coherence angiography.

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4.  Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser.

Authors:  Thomas Klein; Wolfgang Wieser; Christoph M Eigenwillig; Benjamin R Biedermann; Robert Huber
Journal:  Opt Express       Date:  2011-02-14       Impact factor: 3.894

5.  Rapidly swept, ultra-widely-tunable 1060 nm MEMS-VCSELs.

Authors:  V Jayaraman; G D Cole; M Robertson; C Burgner; D John; A Uddin; A Cable
Journal:  Electron Lett       Date:  2012-10-11       Impact factor: 1.314

6.  Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror.

Authors:  Chen D Lu; Martin F Kraus; Benjamin Potsaid; Jonathan J Liu; Woojhon Choi; Vijaysekhar Jayaraman; Alex E Cable; Joachim Hornegger; Jay S Duker; James G Fujimoto
Journal:  Biomed Opt Express       Date:  2013-12-20       Impact factor: 3.732

7.  Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source.

Authors:  WooJhon Choi; Benjamin Potsaid; Vijaysekhar Jayaraman; Bernhard Baumann; Ireneusz Grulkowski; Jonathan J Liu; Chen D Lu; Alex E Cable; David Huang; Jay S Duker; James G Fujimoto
Journal:  Opt Lett       Date:  2013-02-01       Impact factor: 3.776

8.  High-precision, high-accuracy ultralong-range swept-source optical coherence tomography using vertical cavity surface emitting laser light source.

Authors:  Ireneusz Grulkowski; Jonathan J Liu; Benjamin Potsaid; Vijaysekhar Jayaraman; James Jiang; James G Fujimoto; Alex E Cable
Journal:  Opt Lett       Date:  2013-03-01       Impact factor: 3.776

9.  Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers.

Authors:  Ireneusz Grulkowski; Jonathan J Liu; Benjamin Potsaid; Vijaysekhar Jayaraman; Chen D Lu; James Jiang; Alex E Cable; Jay S Duker; James G Fujimoto
Journal:  Biomed Opt Express       Date:  2012-10-03       Impact factor: 3.732

10.  Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography.

Authors:  WooJhon Choi; Kathrin J Mohler; Benjamin Potsaid; Chen D Lu; Jonathan J Liu; Vijaysekhar Jayaraman; Alex E Cable; Jay S Duker; Robert Huber; James G Fujimoto
Journal:  PLoS One       Date:  2013-12-11       Impact factor: 3.240

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  9 in total

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Journal:  Biomed Opt Express       Date:  2016-06-02       Impact factor: 3.732

2.  Cubic meter volume optical coherence tomography.

Authors:  Zhao Wang; Benjamin Potsaid; Long Chen; Chris Doerr; Hsiang-Chieh Lee; Torben Nielson; Vijaysekhar Jayaraman; Alex E Cable; Eric Swanson; James G Fujimoto
Journal:  Optica       Date:  2016-12-15       Impact factor: 11.104

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Journal:  Biomed Opt Express       Date:  2016-07-12       Impact factor: 3.732

4.  Demonstration of Shot-noise-limited Swept Source OCT Without Balanced Detection.

Authors:  Vala Fathipour; Tilman Schmoll; Alireza Bonakdar; Skylar Wheaton; Hooman Mohseni
Journal:  Sci Rep       Date:  2017-04-26       Impact factor: 4.379

5.  Dynamical dispersion engineering in coupled vertical cavities employing a high-contrast grating.

Authors:  Alireza Taghizadeh; Il-Sug Chung
Journal:  Sci Rep       Date:  2017-05-18       Impact factor: 4.379

6.  New Endoscopic Imaging Technology Based on MEMS Sensors and Actuators.

Authors:  Zhen Qiu; Wibool Piyawattanamatha
Journal:  Micromachines (Basel)       Date:  2017-07-02       Impact factor: 2.891

7.  Vertical-cavity surface-emitting laser sources for gigahertz-bandwidth, multiwavelength frequency-domain photon migration.

Authors:  Thomas D O'Sullivan; Keunsik No; Alex Matlock; Robert V Warren; Brian Hill; Albert E Cerussi; Bruce J Tromberg
Journal:  J Biomed Opt       Date:  2017-10       Impact factor: 3.170

8.  Recovering distance information in spectral domain interferometry.

Authors:  Adrian Bradu; Niels Møller Israelsen; Michael Maria; Manuel J Marques; Sylvain Rivet; Thomas Feuchter; Ole Bang; Adrian Podoleanu
Journal:  Sci Rep       Date:  2018-10-18       Impact factor: 4.379

9.  High speed, long range, deep penetration swept source OCT for structural and angiographic imaging of the anterior eye.

Authors:  Siyu Chen; Benjamin Potsaid; Yan Li; Junhong Lin; Yunchan Hwang; Eric M Moult; Jason Zhang; David Huang; James G Fujimoto
Journal:  Sci Rep       Date:  2022-01-19       Impact factor: 4.379

  9 in total

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