Literature DB >> 2658976

Interleukin-1 and lipid metabolism in the rat.

J M Argilés1, F J Lopez-Soriano, R D Evans, D H Williamson.   

Abstract

Intravenous administration of a single dose (20 micrograms) of recombinant interleukin-1-beta to virgin, lactating and litter-removed rats rapidly decreased intestinal lipid absorption in all groups. In vivo, oxidation of [14C]triolein to 14CO2 was also significantly decreased by interleukin-1. In addition, the cytokine decreased [14C]lipid accumulation in the mammary gland of lactating rats and in the adipose tissue of virgin and litter-removed rats. The decrease in lipid uptake in the interleukin-treated rats was accompanied by hypertriglyceridaemia; however, there was no significant decrease in tissue lipoprotein lipase activity, except in heart from lactating rats. In contrast, interleukin-1 administration had no effect on lipogenesis in liver, white or brown adipose tissue of virgin rats fed on glucose. These results suggest that interleukin-1 profoundly affects lipid metabolism by delaying intestinal absorption and decreasing tissue uptake.

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Year:  1989        PMID： 2658976      PMCID： PMC1138571          DOI： 10.1042/bj2590673

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  33 in total

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Journal:  J Lipid Res       Date:  1976-09       Impact factor: 5.922

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Authors:  C A Dinarello
Journal:  N Engl J Med       Date:  1984-11-29       Impact factor: 91.245

5.  Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin.

Authors:  L Agius; A M Robinson; J R Girard; D H Williamson
Journal:  Biochem J       Date:  1979-06-15       Impact factor: 3.857

6.  Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.

Authors:  A M Robinson; J R Girard; D H Williamson
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857

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Journal:  Adv Enzyme Regul       Date:  1983

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Authors:  P R Bachwich; S W Chensue; J W Larrick; S L Kunkel
Journal:  Biochem Biophys Res Commun       Date:  1986-04-14       Impact factor: 3.575

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Authors:  P P Nawroth; I Bank; D Handley; J Cassimeris; L Chess; D Stern
Journal:  J Exp Med       Date:  1986-06-01       Impact factor: 14.307

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Journal:  J Exp Med       Date:  1986-06-01       Impact factor: 14.307
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  15 in total

1.  Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.

Authors:  R D Evans; V Ilic; D H Williamson
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

2.  Implication of low level inflammation in the insulin resistance of adipose tissue at late pregnancy.

Authors:  J de Castro; J Sevillano; J Marciniak; R Rodriguez; C González-Martín; M Viana; O H Eun-suk; S Hauguel de Mouzon; E Herrera; M P Ramos
Journal:  Endocrinology       Date:  2011-09-13       Impact factor: 4.736

3.  Comparative effects of tumour necrosis factor-alpha (cachectin), interleukin-1-beta and tumour growth on amino acid metabolism in the rat in vivo. Absorption and tissue uptake of alpha-amino[1-14C]isobutyrate.

Authors:  J M Argilés; F J López-Soriano; D Wiggins; D H Williamson
Journal:  Biochem J       Date:  1989-07-15       Impact factor: 3.857

4.  Lipid metabolism in the obese Zucker rat. Disposal of an oral [14C]triolein load and lipoprotein lipase activity.

Authors:  E J López-Soriano; N Carbó; J M Argilés
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

5.  Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis.

Authors:  R D Evans; V Ilic; D H Williamson
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

6.  Lipid metabolism during the initiation of lactation in the rat. The effects of starvation and tumour growth.

Authors:  R D Evans; D H Williamson
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

7.  Gene expression profiles characterize inflammation stages in the acute lung injury in mice.

Authors:  Isabelle Lesur; Julien Textoris; Béatrice Loriod; Cécile Courbon; Stéphane Garcia; Marc Leone; Catherine Nguyen
Journal:  PLoS One       Date:  2010-07-08       Impact factor: 3.240

8.  Acute effects of endotoxin (lipopolysaccharide) on tissue lipid metabolism in the lactating rat. The role of delivery of intestinal glucose.

Authors:  F J López-Soriano; D H Williamson
Journal:  Mol Cell Biochem       Date:  1994-12-21       Impact factor: 3.396

9.  Effects of tumour necrosis factor-alpha (cachectin) on glucose metabolism in the rat. Intestinal absorption and isolated enterocyte metabolism.

Authors:  J Arbós; F J López-Soriano; N Carbó; J M Argilés
Journal:  Mol Cell Biochem       Date:  1992-05-13       Impact factor: 3.396

10.  Bacterial lipopolysaccharide (LPS) and interleukin 1 (IL-1) exert multiple physiological effects in the tilapia Oreochromis mossambicus (Teleostei).

Authors:  P H Balm; E van Lieshout; J Lokate; S E Wendelaar Bonga
Journal:  J Comp Physiol B       Date:  1995       Impact factor: 2.200
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