Literature DB >> 728115

Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.

A M Robinson, J R Girard, D H Williamson.   

Abstract

Fatty acid synthesis in the mammary gland of lactating rats in vivo was 5-fold higher than in the liver. Starvation decreased fatty acid synthesis in the gland 50-fold, whereas refeeding for 2h completely reversed this change. The plasma insulin concentration decreased 2-fold in starvation and was restored to the fed-rat value on refeeding. Glucagon and prolactin concentrations did not always change in parallel with lipogenesis, suggesting that insulin may be a regulator of this process in the gland.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 728115      PMCID： PMC1186235          DOI： 10.1042/bj1760343

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  31 in total

1.  Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.

Authors:  D Stansbie; R W Brownsey; M Crettaz; R M Denton
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

2.  Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

Authors:  D H WILLIAMSON; J MELLANBY; H A KREBS
Journal:  Biochem J       Date:  1962-01       Impact factor: 3.857

3.  Alterations in regulation of insulin biosynthesis in pregnancy and starvation studied in isolated rat islets of langerhans.

Authors:  A J Bone; S L Howell
Journal:  Biochem J       Date:  1977-09-15       Impact factor: 3.857

4.  Persistent effects of starvation on pyruvate dehydrogenase kinase and phosphatase of lactating rat mammary gland [proceedings].

Authors:  M A Baxter; H G Coore
Journal:  Biochem Soc Trans       Date:  1978       Impact factor: 5.407

5.  Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture.

Authors:  C K Osborne; M E Monaco; M E Lippman; C R Kahn
Journal:  Cancer Res       Date:  1978-01       Impact factor: 12.701

6.  Control of glucose metabolism in lactating-rat mammary gland: effects of other substrates, insulin and starvation [proceedings].

Authors:  D H Williamson; A M Robinson
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

7.  Fatty acid synthesis in adipose tissue incubated in tritiated water.

Authors:  R L Jungas
Journal:  Biochemistry       Date:  1968-10       Impact factor: 3.162

8.  A method for measuring rates of lactose synthesis in vivo in laboratory animals [proceedings].

Authors:  D T Carrick; N J Kuhn
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

9.  Hypothalamic influence on insulin and glucagon release in the rat.

Authors:  A de Jong; J H Strubbe; A B Steffens
Journal:  Am J Physiol       Date:  1977-11

10.  Comparison of glucose metabolism in the lactating mammary gland of the rat in vivo and in vitro. Effects of starvation, prolactin or insulin deficiency.

Authors:  A M Robinson; D H Williamson
Journal:  Biochem J       Date:  1977-04-15       Impact factor: 3.857
View more
  67 in total

1.  Dermot Hedley (Derek) Williamson (1929-1998).

Authors:  T H Da Costa; R D Evans
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-04       Impact factor: 2.673

2.  Regulation of the activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in mammary gland and liver of lactating rats. Effects of starvation, prolactin and insulin deficiency.

Authors:  M E Brosnan; V Ilic; D H Williamson
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

3.  Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state.

Authors:  R G Jones; V Ilic; D H Williamson
Journal:  Biochem J       Date:  1984-10-15       Impact factor: 3.857

4.  Acute change in the cyclic AMP content of rat mammary acini in vitro. Influence of physiological and pharmacological agents.

Authors:  R A Clegg; I Mullaney
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857

5.  Differences between lactating and non-lactating dairy cows in concentration and secretion rate of insulin.

Authors:  M A Lomax; G D Baird; C B Mallinson; H W Symonds
Journal:  Biochem J       Date:  1979-05-15       Impact factor: 3.857

6.  Changes in the proportion of acetyl-CoA carboxylase in the active form in rat liver. Effect of starvation, lactation and weaning.

Authors:  V A Zammit; C G Corstorphine
Journal:  Biochem J       Date:  1982-06-15       Impact factor: 3.857

7.  Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of starvation and of insulin and prolactin deficiency on the fraction of the enzyme in the active form in vivo.

Authors:  E M McNeillie; V A Zammit
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

8.  Regulation of peripheral lipogenesis by glucagon. Inability of the hormone to inhibit lipogenesis in rat mammary acini in vitro in the presence or absence of agents which alter its effects on adipocytes.

Authors:  N A Robson; R A Clegg; V A Zammit
Journal:  Biochem J       Date:  1984-02-01       Impact factor: 3.857

9.  Regulation of rat mammary-gland uptake of orally administered [1-14C]triolein by insulin and prolactin: evidence for bihormonal control of lipoprotein lipase activity.

Authors:  T H Da Costa; D H Williamson
Journal:  Biochem J       Date:  1994-05-15       Impact factor: 3.857

10.  Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis.

Authors:  V L Albaugh; J G Judson; P She; C H Lang; K P Maresca; J L Joyal; C J Lynch
Journal:  Mol Psychiatry       Date:  2010-03-23       Impact factor: 15.992
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.