Literature DB >> 2165397

Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis.

R D Evans1, V Ilic, D H Williamson.   

Abstract

1. The effects of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; PAF) on hepatic metabolism in vivo in rats were studied. 2. PAF stimulated synthesis of hepatic lipid (saponified and non-saponified) in a dose-dependent fashion and caused hypertriglyceridaemia. There was no effect of PAF on lipogenesis in isolated hepatocytes. 3. High doses of PAF also decreased hepatic glycogen. 4. All doses of PAF decreased plasma insulin, and this was accompanied by hyperglycaemia, except at the lowest dose. 5. The selective PAF-receptor antagonist L659.989 prevented the stimulation of lipogenesis, but indomethacin did not.

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Year:  1990        PMID： 2165397      PMCID： PMC1131564          DOI： 10.1042/bj2690269

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.

Authors:  D Stansbie; R W Brownsey; M Crettaz; R M Denton
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

2.  [A simple technic for extremely rapid freezing of large pieces of tissue].

Authors:  A WOLLENBERGER; O RISTAU; G SCHOFFA
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1960

3.  [A new determination of the neutral fats in blood serum and tissue. I. Principles, procedure, and discussion of the method].

Authors:  M Eggstein; F H Kreutz
Journal:  Klin Wochenschr       Date:  1966-03-01

4.  Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.

Authors:  A M Robinson; J R Girard; D H Williamson
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857

5.  The effect of acetylglyceryl ether phosphorylcholine on glycogenolysis and phosphatidylinositol 4,5-bisphosphate metabolism in rat hepatocytes.

Authors:  R A Fisher; S D Shukla; M S Debuysere; D J Hanahan; M S Olson
Journal:  J Biol Chem       Date:  1984-07-25       Impact factor: 5.157

6.  Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin.

Authors:  F Gonzalez-Crussi; W Hsueh
Journal:  Am J Pathol       Date:  1983-07       Impact factor: 4.307

7.  Effects of inhibition of protein synthesis by cycloheximide on lipogenesis in mammary gland and liver of lactating rats.

Authors:  A F Roberts; J R Viña; M R Munday; R Farrell; D H Williamson
Journal:  Biochem J       Date:  1982-05-15       Impact factor: 3.857

8.  Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine.

Authors:  D B Buxton; S D Shukla; D J Hanahan; M S Olson
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

9.  Regulation of cholesterol synthesis in the liver and mammary gland of the lactating rat.

Authors:  G F Gibbons; C R Pullinger; M R Munday; D H Williamson
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

10.  Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.

Authors:  S D Shukla; D B Buxton; M S Olson; D J Hanahan
Journal:  J Biol Chem       Date:  1983-09-10       Impact factor: 5.157
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  2 in total

1.  Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.

Authors:  R D Evans; V Ilic; D H Williamson
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

2.  Is hypertriglyceridemia a prognostic factor in sepsis?

Authors:  Ali Cetinkaya; Abdulsamet Erden; Deniz Avci; Hatice Karagoz; Samet Karahan; Mustafa Basak; Kadir Bulut; Vedat Gencer; Hasan Mutlu
Journal:  Ther Clin Risk Manag       Date:  2014-02-27       Impact factor: 2.423
  2 in total

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