Literature DB >> 26566970

"This lifetime commitment": Public conceptions of disability and noninvasive prenatal genetic screening.

Rosemary J Steinbach1, Megan Allyse2, Marsha Michie3, Emily Y Liu1, Mildred K Cho1.   

Abstract

Recently, new noninvasive prenatal genetic screening technologies for Down syndrome and other genetic conditions have become commercially available. Unique characteristics of these screening tests have reignited long-standing concerns about prenatal testing for intellectual and developmental disabilities. We conducted a web-based survey of a sample of the US public to examine how attitudes towards disability inform views of prenatal testing in the context of these rapidly advancing prenatal genetic screening technologies. Regardless of opinion toward disability, the majority of respondents supported both the availability of screening and the decision to continue a pregnancy positive for aneuploidy. Individuals rationalized their support with various conceptions of disability; complications of the expressivist argument and other concerns from the disability literature were manifested in many responses analyzed.
© 2015 Wiley Periodicals, Inc.

Entities:  

Keywords:  NIPS; cell-free DNA; disability rights; down syndrome; intellectual disabilities; noninvasive prenatal screening; prenatal testing; public opinion; trisomy

Mesh:

Year:  2015        PMID: 26566970      PMCID: PMC4948186          DOI: 10.1002/ajmg.a.37459

Source DB:  PubMed          Journal:  Am J Med Genet A        ISSN: 1552-4825            Impact factor:   2.802


  56 in total

1.  A population-based evaluation of the impact of antenatal screening for Down's syndrome in France, 1981-2000.

Authors:  Babak Khoshnood; Catherine De Vigan; Véronique Vodovar; Janine Goujard; François Goffinet
Journal:  BJOG       Date:  2004-05       Impact factor: 6.531

Review 2.  Prenatal diagnosis and selective abortion: a challenge to practice and policy.

Authors:  A Asch
Journal:  Am J Public Health       Date:  1999-11       Impact factor: 9.308

3.  Noninvasive prenatal testing goes global.

Authors:  Subhashini Chandrasekharan; Mollie A Minear; Anthony Hung; Megan Allyse
Journal:  Sci Transl Med       Date:  2014-04-09       Impact factor: 17.956

4.  Birth prevalence of Down syndrome in Singapore from 1993 to 1998.

Authors:  F M Lai; B H Woo; K H Tan; J Huang; S T Lee; T B Yan; B H Tan; S K Chew; G S H Yeo
Journal:  Singapore Med J       Date:  2002-02       Impact factor: 1.858

5.  Noninvasive prenatal diagnosis: pregnant women's interest and expected uptake.

Authors:  Reana Tischler; Louanne Hudgins; Yair J Blumenfeld; Henry T Greely; Kelly E Ormond
Journal:  Prenat Diagn       Date:  2011-10-26       Impact factor: 3.050

6.  Uptake of noninvasive prenatal testing (NIPT) in women following positive aneuploidy screening.

Authors:  Shilpa Chetty; Matthew J Garabedian; Mary E Norton
Journal:  Prenat Diagn       Date:  2013-06       Impact factor: 3.050

7.  Attitudes towards non-invasive prenatal testing for aneuploidy among US adults of reproductive age.

Authors:  M Allyse; L C Sayres; T A Goodspeed; M K Cho
Journal:  J Perinatol       Date:  2014-03-06       Impact factor: 2.521

8.  DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study.

Authors:  Glenn E Palomaki; Cosmin Deciu; Edward M Kloza; Geralyn M Lambert-Messerlian; James E Haddow; Louis M Neveux; Mathias Ehrich; Dirk van den Boom; Allan T Bombard; Wayne W Grody; Stanley F Nelson; Jacob A Canick
Journal:  Genet Med       Date:  2012-02-02       Impact factor: 8.822

9.  Avoiding genetic genocide: understanding good intentions and eugenics in the complex dialogue between the medical and disability communities.

Authors:  Paul Steven Miller; Rebecca Leah Levine
Journal:  Genet Med       Date:  2012-08-16       Impact factor: 8.822

10.  Views and preferences for the implementation of non-invasive prenatal diagnosis for single gene disorders from health professionals in the United Kingdom.

Authors:  Melissa Hill; Madhavi Karunaratna; Celine Lewis; Frida Forya; Lyn Chitty
Journal:  Am J Med Genet A       Date:  2013-05-21       Impact factor: 2.802

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  2 in total

1.  Patients' Knowledge of Prenatal Screening for Trisomy 21.

Authors:  Michal Sheinis; Kira Bensimon; Amanda Selk
Journal:  J Genet Couns       Date:  2017-07-14       Impact factor: 2.537

Review 2.  Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome?

Authors:  Melissa Hill; Angela Barrett; Mahesh Choolani; Celine Lewis; Jane Fisher; Lyn S Chitty
Journal:  Prenat Diagn       Date:  2017-12       Impact factor: 3.050

  2 in total

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