Literature DB >> 26523747

Broader Geographic Sharing of Pediatric Donor Lungs Improves Pediatric Access to Transplant.

W M Tsuang1, K M Chan2, M A Skeans3, J Pyke3, M I Hertz3,4, A J Israni3,4,5, L Robbins-Callahan6, G Visner7, X Wang3, T C Wozniak8, M Valapour1,3.   

Abstract

US pediatric transplant candidates have limited access to lung transplant due to the small number of donors within current geographic boundaries, leading to assertions that the current lung allocation system does not adequately serve pediatric patients. We hypothesized that broader geographic sharing of pediatric (adolescent, 12-17 years; child, <12 years) donor lungs would increase pediatric candidate access to transplant. We used the thoracic simulated allocation model to simulate broader geographic sharing. Simulation 1 used current allocation rules. Simulation 2 offered adolescent donor lungs across a wider geographic area to adolescents. Simulation 3 offered child donor lungs across a wider geographic area to adolescents. Simulation 4 combined simulations 2 and 3. Simulation 5 prioritized adolescent donor lungs to children across a wider geographic area. Simulation 4 resulted in 461 adolescent transplants per 100 patient-years on the waiting list (range 417-542), compared with 206 (range 180-228) under current rules. Simulation 5 resulted in 388 adolescent transplants per 100 patient-years on the waiting list (range 348-418) and likely increased transplant rates for children. Adult transplant rates, waitlist mortality, and 1-year posttransplant mortality were not adversely affected. Broader geographic sharing of pediatric donor lungs may increase pediatric candidate access to lung transplant. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

Entities:  

Keywords:  Scientific Registry for Transplant Recipients (SRTR); donation; donors; health services and outcomes research; lung transplantation; pulmonology

Mesh:

Year:  2015        PMID: 26523747     DOI: 10.1111/ajt.13507

Source DB:  PubMed          Journal:  Am J Transplant        ISSN: 1600-6135            Impact factor:   8.086


  4 in total

1.  Contemporary Issues in Lung Transplant Allocation Practices.

Authors:  Wayne M Tsuang
Journal:  Curr Transplant Rep       Date:  2017-07-21

2.  Effect of broader geographic sharing of donor lungs on lung transplant waitlist outcomes.

Authors:  Joshua J Mooney; Jay Bhattacharya; Gundeep S Dhillon
Journal:  J Heart Lung Transplant       Date:  2018-09-14       Impact factor: 10.247

3.  High emergency organ allocation rule in lung transplantation: a simulation study.

Authors:  Julien Riou; Pierre-Yves Boëlle; Jason D Christie; Gabriel Thabut
Journal:  ERJ Open Res       Date:  2017-11-20

4.  Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching.

Authors:  Matthias Niemann; Nils Lachmann; Kirsten Geneugelijk; Eric Spierings
Journal:  PLoS Comput Biol       Date:  2021-07-27       Impact factor: 4.475

  4 in total

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