Wayne M Tsuang1. 1. Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Abstract
PURPOSE OF REVIEW: To discuss the current state of donor lung allocation in the United States, and future opportunities to increase the efficiency of donor lung allocation. RECENT FINDINGS: The current donor lung allocation system prioritizes clinical acuity by use of the Lung Allocation Score (LAS) which has reduced waitlist mortality since its implementation in 2005. Access to donor lungs can be further improved through policy changes using broader geographic sharing, and developing new technology such as ex vivo lung perfusion to recover marginal donor lungs. SUMMARY: The number of lung transplants in the U.S. continues to increase annually. However, the demand for donor lungs continues to be outpaced by an ever growing waitlist. Efficient allocation can be achieved through improved allocation policies and new technology.
PURPOSE OF REVIEW: To discuss the current state of donor lung allocation in the United States, and future opportunities to increase the efficiency of donor lung allocation. RECENT FINDINGS: The current donor lung allocation system prioritizes clinical acuity by use of the Lung Allocation Score (LAS) which has reduced waitlist mortality since its implementation in 2005. Access to donor lungs can be further improved through policy changes using broader geographic sharing, and developing new technology such as ex vivo lung perfusion to recover marginal donor lungs. SUMMARY: The number of lung transplants in the U.S. continues to increase annually. However, the demand for donor lungs continues to be outpaced by an ever growing waitlist. Efficient allocation can be achieved through improved allocation policies and new technology.
Authors: Marcelo Cypel; Jonathan C Yeung; Mingyao Liu; Masaki Anraku; Fengshi Chen; Wojtek Karolak; Masaaki Sato; Jane Laratta; Sassan Azad; Mindy Madonik; Chung-Wai Chow; Cecilia Chaparro; Michael Hutcheon; Lianne G Singer; Arthur S Slutsky; Kazuhiro Yasufuku; Marc de Perrot; Andrew F Pierre; Thomas K Waddell; Shaf Keshavjee Journal: N Engl J Med Date: 2011-04-14 Impact factor: 91.245
Authors: M Colvin-Adams; M Valapour; M Hertz; B Heubner; K Paulson; V Dhungel; M A Skeans; L Edwards; V Ghimire; C Waller; W S Cherikh; B L Kasiske; J J Snyder; A K Israni Journal: Am J Transplant Date: 2012-09-13 Impact factor: 8.086
Authors: Alexander Iribarne; David O Meltzer; Dhaval Chauhan; Joshua R Sonett; Robert D Gibbons; Wickii Vigneswaran; Mark J Russo Journal: Clin Transplant Date: 2016-04-15 Impact factor: 2.863
Authors: S E Gentry; A B Massie; S W Cheek; K L Lentine; E H Chow; C E Wickliffe; N Dzebashvili; P R Salvalaggio; M A Schnitzler; D A Axelrod; D L Segev Journal: Am J Transplant Date: 2013-07-09 Impact factor: 8.086
Authors: Awori J Hayanga; Jonathan K Aboagye; Heather E Hayanga; Matthew Morrell; Lynn Huffman; Norihisa Shigemura; Jay K Bhama; Jonathan D'Cunha; Christian A Bermudez Journal: J Heart Lung Transplant Date: 2014-11-06 Impact factor: 10.247
Authors: Mark J Russo; David Meltzer; Aurelie Merlo; Elizabeth Johnson; Nazly M Shariati; Joshua R Sonett; Robert Gibbons Journal: Ann Thorac Surg Date: 2013-01-24 Impact factor: 4.330
Authors: Miae Kim; Keri R Townsend; Isabelle G Wood; Steve Boukedes; Indira Guleria; Steven Gabardi; Souheil El-Chemaly; Phillip C Camp; Anil K Chandraker; Edgar L Milford; Hilary J Goldberg Journal: Am J Respir Crit Care Med Date: 2014-05-15 Impact factor: 21.405
Authors: Ajay K Israni; Nicholas Salkowski; Sally Gustafson; Jon J Snyder; John J Friedewald; Richard N Formica; Xinyue Wang; Eugene Shteyn; Wida Cherikh; Darren Stewart; Ciara J Samana; Adrine Chung; Allyson Hart; Bertram L Kasiske Journal: J Am Soc Nephrol Date: 2014-05-15 Impact factor: 10.121