Ming Zhao1, Monday M Onakpa1,2, Bernard D Santarsiero3, Wei-Lun Chen1, Karina M Szymulanska-Ramamurthy1, Steven M Swanson1,4, Joanna E Burdette1, Chun-Tao Che1. 1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States. 2. Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja , Abuja 920001, Nigeria. 3. Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago , Chicago, Illinois 60607, United States. 4. School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Abstract
New 17-nor-pimaranes (1, 2), (9βH)-pimaranes (3, 4), and 17-nor-(9βH)-pimarane (5) were isolated from the tuber of Icacina trichantha. The structures were elucidated based on spectroscopic and HRMS data. The absolute configurations of 3 and 5 were determined by single-crystal X-ray diffraction. Compound 5 possesses a unique 19,20-δ-lactone moiety. Compound 3 showed cytotoxicity against MDA-MB-435 (human melanoma cancer) cells with an IC50 value of 7.04 μM. A plausible biogenetic pathway for compounds 1-5 is proposed.
New 17-nor-pimaranes (1, 2), (9βH)-n class="Chemical">pimaranes (3, 4), and 17-nor-(9βH)-pimarane (5) were isolated from the tuber of Icacina trichantha. The structures were elucidated based on spectroscopic and HRMS data. The absolute configurations of 3 and 5 were determined by single-crystal X-ray diffraction. Compound 5 possesses a unique 19,20-δ-lactone moiety. Compound 3 showed cytotoxicity against MDA-MB-435 (humanmelanoma cancer) cells with an IC50 value of 7.04 μM. A plausible biogenetic pathway for compounds 1-5 is proposed.
Authors: Ming Zhao; Monday M Onakpa; Bernard D Santarsiero; Xiao-Jun Huang; Xiao-Qi Zhang; Jia Chen; Jian-Jun Cheng; Richard Longnecker; Chun-Tao Che Journal: Org Lett Date: 2015-07-17 Impact factor: 6.005
Authors: Ming Zhao; Michael Monday Onakpa; Wei-Lun Chen; Bernard D Santarsiero; Steven M Swanson; Joanna E Burdette; Isaac Uzoma Asuzu; Chun-Tao Che Journal: J Nat Prod Date: 2015-03-17 Impact factor: 4.050
Authors: Michael Monday Onakpa; Ming Zhao; Tanja Gödecke; Wei-Lun Chen; Chun-Tao Che; Bernard D Santarsiero; Steven M Swanson; Isaac Uzoma Asuzu Journal: Chem Biodivers Date: 2014-12 Impact factor: 2.408
Authors: Yulin Ren; Wei-Lun Chen; Daniel D Lantvit; Ellen J Sass; Pratik Shriwas; Tran Ngoc Ninh; Hee-Byung Chai; Xiaoli Zhang; Djaja D Soejarto; Xiaozhuo Chen; David M Lucas; Steven M Swanson; Joanna E Burdette; A Douglas Kinghorn Journal: J Nat Prod Date: 2016-12-16 Impact factor: 4.050
Authors: Brian Guo; Ming Zhao; Zhenlong Wu; Monday M Onakpa; Joanna E Burdette; Chun-Tao Che Journal: Fitoterapia Date: 2020-05-11 Impact factor: 2.882
Authors: Brian Guo; Monday M Onakpa; Xiao-Jun Huang; Bernard D Santarsiero; Wei-Lun Chen; Ming Zhao; Xiao-Qi Zhang; Steven M Swanson; Joanna E Burdette; Chun-Tao Che Journal: J Nat Prod Date: 2016-06-24 Impact factor: 4.050