| Literature DB >> 26183449 |
Ming Zhao1, Monday M Onakpa1,2, Bernard D Santarsiero3, Xiao-Jun Huang4, Xiao-Qi Zhang1,4, Jia Chen5, Jian-Jun Cheng1, Richard Longnecker5, Chun-Tao Che1.
Abstract
The 17-norpimarane diterpene is a small group of natural products. A new member, icacinlactone H (1), and a new rearranged 17-norpimarane with an unprecedented carbon skeleton, icacintrichantholide (2), were isolated from Icacina trichantha. Their structures including the absolute configuration were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. A plausible biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant activity against herpes simplex viruses HSV-1 and HSV-2 as well as the Epstein-Barr virus at 50 μM.Entities:
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Year: 2015 PMID： 26183449 DOI： 10.1021/acs.orglett.5b01806
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005