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Literature DB >> 25782063

17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha.

Ming Zhao¹, Michael Monday Onakpa^1,2, Wei-Lun Chen¹, Bernard D Santarsiero³, Steven M Swanson^1,4, Joanna E Burdette¹, Isaac Uzoma Asuzu², Chun-Tao Che¹.

Abstract

Seven new 17-norpimarane and (9βH)-17-norpimarane diterpenoids, icacinlactones A-G (1-7), were isolated from the tuber of Icacina trichantha. The structures were elucidated by spectroscopic and HRMS techniques, and the absolute configuration of 2 was determined by means of X-ray crystallographic analysis. Compounds 1-7, as well as four known related structures, were evaluated for cytotoxic activity against MDA-MB-435 (human melanoma cancer), MDA-MB-231 (human breast cancer), and OVCAR3 (human ovarian cancer) cell lines. Several of these natural products displayed significant cytotoxic activity, with humirianthenolide C being the most active.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2015 PMID： 25782063 PMCID： PMC4703125 DOI： 10.1021/np5010328

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

6 in total

1. Diterpenoids from Humirianthera ampla.

Authors: I B Graebner; M A Mostardeiro; E M Ethur; R A Burrow; E C Dessoy; A F Morel
Journal: Phytochemistry Date: 2000-04 Impact factor: 4.072

2. Screening of Icacina trichantha extracts for pharmacological activity.

Authors: I U Asuzu; E E Ugwueze
Journal: J Ethnopharmacol Date: 1990-02 Impact factor: 4.360

3. Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta-cells of alloxan induced diabetic rats.

Authors: Onakpa Michael Monday; Asuzu Isaac Uzoma
Journal: Asian Pac J Trop Biomed Date: 2013-08

4. Cytotoxic diterpenoids from two lianas from the Suriname rainforest.

Authors: Eba Adou; Russell B Williams; Jennifer K Schilling; Stan Malone; Jan Meyer; Jan H Wisse; Djon Frederik; Delon Koese; Marga C M Werkhoven; Carl E Snipes; Todd L Werk; David G I Kingston
Journal: Bioorg Med Chem Date: 2005-11-01 Impact factor: 3.641

5. Cytotoxic (9βH)-pimarane and (9βH)-17-norpimarane diterpenes from the tuber of Icacina trichantha.

Authors: Michael Monday Onakpa; Ming Zhao; Tanja Gödecke; Wei-Lun Chen; Chun-Tao Che; Bernard D Santarsiero; Steven M Swanson; Isaac Uzoma Asuzu
Journal: Chem Biodivers Date: 2014-12 Impact factor: 2.408

6. Search for the centrally active component of Icacina trichantha tuber.

Authors: I U Asuzu; O K Egwu
Journal: Phytomedicine Date: 1998-03 Impact factor: 5.340

6 in total

8 in total

17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha.

1. Diterpenoids from Humirianthera ampla.

2. Screening of Icacina trichantha extracts for pharmacological activity.

3. Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta-cells of alloxan induced diabetic rats.

4. Cytotoxic diterpenoids from two lianas from the Suriname rainforest.

5. Cytotoxic (9βH)-pimarane and (9βH)-17-norpimarane diterpenes from the tuber of Icacina trichantha.

6. Search for the centrally active component of Icacina trichantha tuber.

1. Activity of Icacinol from Icacina trichantha on Seedling Growth of Oryza sativa and Arabidopsis thaliana.

2. 19-nor-pimaranes from Icacina trichantha.

3. (9βH)- and 17-Nor-Pimaranes from Icacina oliviformis.

Review 4. Icacina trichantha, A Tropical Medicinal Plant.

5. Di-nor- and 17-nor-pimaranes from Icacina trichantha.

6. (9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha.

7. Phytochemical study of Illicium angustisepalum and its biological activities.

Review 8. A Synthetic View on Momilactones and Related 9β-H Pimarane Skeleton Diterpenoids.