PURPOSE: Zr-89 positron emission tomography (PET) is a valuable tool for understanding the biodistribution and pharmacokinetics of antibody-based therapeutics. We compared the image quality of Zr-89 PET and F-18 PET in the Siemens microPET Focus 220 preclinical scanner using different reconstruction methods. PROCEDURES: Image quality metrics were measured in various Zr-89 and F-18 PET phantoms, including the NEMA NU 4-2008 image quality phantom. Images were reconstructed using various algorithms. RESULTS: Zr-89 PET had greater image noise, inferior spatial resolution, and greater spillover than F-18 PET, but comparable recovery coefficients for cylinders of various diameters. Of the reconstruction methods, OSEM3D resulted in the lowest noise, highest recovery coefficients, best spatial resolution, but also the greatest spillover. Scatter correction results were found to be sensitive to varying object sizes. CONCLUSIONS: Zr-89 PET image quality was inferior to that of F-18, and no single reconstruction method was superior in all aspects of image quality.
PURPOSE: Zr-89 positron emission tomography (PET) is a valuable tool for understanding the biodistribution and pharmacokinetics of antibody-based therapeutics. We compared the image quality of Zr-89 PET and F-18 PET in the Siemens microPET Focus 220 preclinical scanner using different reconstruction methods. PROCEDURES: Image quality metrics were measured in various Zr-89 and F-18 PET phantoms, including the NEMA NU 4-2008 image quality phantom. Images were reconstructed using various algorithms. RESULTS: Zr-89 PET had greater image noise, inferior spatial resolution, and greater spillover than F-18 PET, but comparable recovery coefficients for cylinders of various diameters. Of the reconstruction methods, OSEM3D resulted in the lowest noise, highest recovery coefficients, best spatial resolution, but also the greatest spillover. Scatter correction results were found to be sensitive to varying object sizes. CONCLUSIONS: Zr-89 PET image quality was inferior to that of F-18, and no single reconstruction method was superior in all aspects of image quality.
Authors: Jonathan A Disselhorst; Maarten Brom; Peter Laverman; Cornelius H Slump; Otto C Boerman; Wim J G Oyen; Martin Gotthardt; Eric P Visser Journal: J Nucl Med Date: 2010-03-17 Impact factor: 10.057
Authors: Yuan-Chuan Tai; Ananya Ruangma; Douglas Rowland; Stefan Siegel; Danny F Newport; Patrick L Chow; Richard Laforest Journal: J Nucl Med Date: 2005-03 Impact factor: 10.057
Authors: Nikolaos E Makris; Ronald Boellaard; Eric P Visser; Johan R de Jong; Bruno Vanderlinden; Roel Wierts; Berlinda J van der Veen; Henri J N M Greuter; Danielle J Vugts; Guus A M S van Dongen; Adriaan A Lammertsma; Marc C Huisman Journal: J Nucl Med Date: 2013-12-19 Impact factor: 10.057
Authors: Andrew L Goertzen; Qinan Bao; Mélanie Bergeron; Eric Blankemeyer; Stephan Blinder; Mario Cañadas; Arion F Chatziioannou; Katherine Dinelle; Esmat Elhami; Hans-Sonke Jans; Eduardo Lage; Roger Lecomte; Vesna Sossi; Suleman Surti; Yuan-Chuan Tai; Juan José Vaquero; Esther Vicente; Darin A Williams; Richard Laforest Journal: J Nucl Med Date: 2012-06-14 Impact factor: 10.057