Literature DB >> 26474062

It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles.

Lin Guo1, James Shorter2.   

Abstract

Paradigm-shifting advances have revealed that diverse membraneless organelles originate via liquid-liquid phase separation, but how their distinct structural and functional milieux are specified is not understood. Recent work elucidates that RNA governs the biophysical characteristics of liquid droplets formed by RNA-binding proteins with low-complexity domains and can decelerate pathogenic fibrillogenesis.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26474062      PMCID： PMC4653132          DOI： 10.1016/j.molcel.2015.10.006

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  12 in total

1.  A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

Authors:  Avinash Patel; Hyun O Lee; Louise Jawerth; Shovamayee Maharana; Marcus Jahnel; Marco Y Hein; Stoyno Stoynov; Julia Mahamid; Shambaditya Saha; Titus M Franzmann; Andrej Pozniakovski; Ina Poser; Nicola Maghelli; Loic A Royer; Martin Weigert; Eugene W Myers; Stephan Grill; David Drechsel; Anthony A Hyman; Simon Alberti
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582

2.  A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship.

Authors:  Fabrice Caudron; Yves Barral
Journal:  Cell       Date:  2013-12-05       Impact factor: 41.582

Review 3.  Nuclear bodies: the emerging biophysics of nucleoplasmic phases.

Authors:  Lian Zhu; Clifford P Brangwynne
Journal:  Curr Opin Cell Biol       Date:  2015-05-15       Impact factor: 8.382

4.  Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.

Authors:  Kathleen A Burke; Abigail M Janke; Christy L Rhine; Nicolas L Fawzi
Journal:  Mol Cell       Date:  2015-10-08       Impact factor: 17.970

5.  Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Authors:  Masato Kato; Tina W Han; Shanhai Xie; Kevin Shi; Xinlin Du; Leeju C Wu; Hamid Mirzaei; Elizabeth J Goldsmith; Jamie Longgood; Jimin Pei; Nick V Grishin; Douglas E Frantz; Jay W Schneider; She Chen; Lin Li; Michael R Sawaya; David Eisenberg; Robert Tycko; Steven L McKnight
Journal:  Cell       Date:  2012-05-11       Impact factor: 41.582

6.  Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.

Authors:  Amandine Molliex; Jamshid Temirov; Jihun Lee; Maura Coughlin; Anderson P Kanagaraj; Hong Joo Kim; Tanja Mittag; J Paul Taylor
Journal:  Cell       Date:  2015-09-24       Impact factor: 41.582

Review 7.  Stress granules as crucibles of ALS pathogenesis.

Authors:  Yun R Li; Oliver D King; James Shorter; Aaron D Gitler
Journal:  J Cell Biol       Date:  2013-04-29       Impact factor: 10.539

8.  Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles.

Authors:  Timothy J Nott; Evangelia Petsalaki; Patrick Farber; Dylan Jervis; Eden Fussner; Anne Plochowietz; Timothy D Craggs; David P Bazett-Jones; Tony Pawson; Julie D Forman-Kay; Andrew J Baldwin
Journal:  Mol Cell       Date:  2015-03-05       Impact factor: 17.970

9.  Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Authors:  Yuan Lin; David S W Protter; Michael K Rosen; Roy Parker
Journal:  Mol Cell       Date:  2015-09-24       Impact factor: 17.970

10.  Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules.

Authors:  Sonja Kroschwald; Shovamayee Maharana; Daniel Mateju; Liliana Malinovska; Elisabeth Nüske; Ina Poser; Doris Richter; Simon Alberti
Journal:  Elife       Date:  2015-08-04       Impact factor: 8.140
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  50 in total

1.  Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies.

Authors:  Tetsuya Kawaguchi; Tetsuro Hirose
Journal:  Nucleus       Date:  2015-12-28       Impact factor: 4.197

2.  The SH3 domain of Fyn kinase interacts with and induces liquid-liquid phase separation of the low-complexity domain of hnRNPA2.

Authors:  Joshua Amaya; Veronica H Ryan; Nicolas L Fawzi
Journal:  J Biol Chem       Date:  2018-11-05       Impact factor: 5.157

3.  Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells.

Authors:  Joseph R Simon; Seyed Ali Eghtesadi; Michael Dzuricky; Lingchong You; Ashutosh Chilkoti
Journal:  Mol Cell       Date:  2019-06-04       Impact factor: 17.970

4.  Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.

Authors:  Jeremy J Ryan; Macy L Sprunger; Kayla Holthaus; James Shorter; Meredith E Jackrel
Journal:  J Biol Chem       Date:  2019-06-05       Impact factor: 5.157

Review 5.  Harnessing biomolecular condensates in living cells.

Authors:  Hideki Nakamura; Robert DeRose; Takanari Inoue
Journal:  J Biochem       Date:  2019-07-01       Impact factor: 3.387

6.  Biphasic adaptation to osmotic stress in the C. elegans germ line.

Authors:  Michael Davis; Andrea Montalbano; Megan P Wood; Jennifer A Schisa
Journal:  Am J Physiol Cell Physiol       Date:  2017-04-05       Impact factor: 4.249

Review 7.  Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Authors:  Lin Guo; James Shorter
Journal:  Cold Spring Harb Perspect Med       Date:  2017-09-01       Impact factor: 6.915

8.  Structure-Dependent Binding of hnRNPA1 to Telomere RNA.

Authors:  Xiao Liu; Takumi Ishizuka; Hong-Liang Bao; Kei Wada; Yuma Takeda; Keisuke Iida; Kazuo Nagasawa; Danzhou Yang; Yan Xu
Journal:  J Am Chem Soc       Date:  2017-05-24       Impact factor: 15.419

Review 9.  RNA Biology in Retinal Development and Disease.

Authors:  Lina Zelinger; Anand Swaroop
Journal:  Trends Genet       Date:  2018-01-31       Impact factor: 11.639

10.  Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.

Authors:  Chan Zhou; Benoit Molinie; Kaveh Daneshvar; Joshua V Pondick; Jinkai Wang; Nicholas Van Wittenberghe; Yi Xing; Cosmas C Giallourakis; Alan C Mullen
Journal:  Cell Rep       Date:  2017-08-29       Impact factor: 9.423
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