| Literature DB >> 26651942 |
Jason T Ladner1, Michael R Wiley2, Suzanne Mate2, Gytis Dudas3, Karla Prieto2, Sean Lovett2, Elyse R Nagle2, Brett Beitzel2, Merle L Gilbert4, Lawrence Fakoli5, Joseph W Diclaro6, Randal J Schoepp7, Joseph Fair8, Jens H Kuhn9, Lisa E Hensley9, Daniel J Park10, Pardis C Sabeti11, Andrew Rambaut12, Mariano Sanchez-Lockhart2, Fatorma K Bolay5, Jeffrey R Kugelman2, Gustavo Palacios13.
Abstract
The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.Entities:
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Year: 2015 PMID： 26651942 PMCID： PMC4711363 DOI： 10.1016/j.chom.2015.11.008
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023