Literature DB >> 26463210

The Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human Health.

Mridusmita Saikia1, Maria Hatzoglou2.   

Abstract

In mammalian cells, mature tRNAs are cleaved by stress-activated ribonuclease angiogenin to generate 5'- and 3'-tRNA halves: a novel class of small non-coding RNAs of 30-40 nucleotides in length. The biogenesis and biological functions of tRNA halves are emerging areas of research. This review will discuss the most recent findings on: (i) the mechanism and regulation of their biogenesis, (ii) their mechanism of action (we will specifically discuss their role in the protein synthesis inhibition and the intrinsic pathway of apoptosis), and (iii) their effects on the human physiology and disease conditions.
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  angiogenin; biomarker; cancer; cellular stress; neurodegeneration; stress; tRNA halves; tiRNA; transfer RNA (tRNA)

Mesh：

Substances：

Year:  2015        PMID： 26463210      PMCID： PMC4705977          DOI： 10.1074/jbc.R115.694661

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  100 in total

1.  The small RNA profile during Drosophila melanogaster development.

Authors:  Alexei A Aravin; Mariana Lagos-Quintana; Abdullah Yalcin; Mihaela Zavolan; Debora Marks; Ben Snyder; Terry Gaasterland; Jutta Meyer; Thomas Tuschl
Journal:  Dev Cell       Date:  2003-08       Impact factor: 12.270

Review 2.  Non-coding RNAs: hope or hype?

Authors:  Alexander Hüttenhofer; Peter Schattner; Norbert Polacek
Journal:  Trends Genet       Date:  2005-05       Impact factor: 11.639

Review 3.  MicroRNA-based therapy and breast cancer: A comprehensive review of novel therapeutic strategies from diagnosis to treatment.

Authors:  Parham Jabbarzadeh Kaboli; Asmah Rahmat; Patimah Ismail; King-Hwa Ling
Journal:  Pharmacol Res       Date:  2015-05-07       Impact factor: 7.658

4.  Angiogenin protects motoneurons against hypoxic injury.

Authors:  J Sebastià; D Kieran; B Breen; M A King; D F Netteland; D Joyce; S F Fitzpatrick; C T Taylor; J H M Prehn
Journal:  Cell Death Differ       Date:  2009-05-15       Impact factor: 15.828

Review 5.  Reduced proliferation and enhanced migration: two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1.

Authors:  Valentina Evdokimova; Cristina Tognon; Tony Ng; Poul H B Sorensen
Journal:  Cell Cycle       Date:  2009-09-16       Impact factor: 4.534

6.  Patterns of urinary excretion of modified nucleosides.

Authors:  C W Gehrke; K C Kuo; T P Waalkes; E Borek
Journal:  Cancer Res       Date:  1979-04       Impact factor: 12.701

7.  A combined kinetic and modeling study of the catalytic center subsites of human angiogenin.

Authors:  N Russo; K R Acharya; B L Vallee; R Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-23       Impact factor: 11.205

8.  Control of motoneuron survival by angiogenin.

Authors:  Dairín Kieran; Jordi Sebastia; Matthew J Greenway; Matthew A King; Dervla Connaughton; Caoimhin G Concannon; Beau Fenner; Orla Hardiman; Jochen H M Prehn
Journal:  J Neurosci       Date:  2008-12-24       Impact factor: 6.167

9.  Conformational change in transfer RNA is an early indicator of acute cellular damage.

Authors:  Eikan Mishima; Chisako Inoue; Daisuke Saigusa; Ryusuke Inoue; Koki Ito; Yusuke Suzuki; Daisuke Jinno; Yuri Tsukui; Yosuke Akamatsu; Masatake Araki; Kimi Araki; Ritsuko Shimizu; Haruka Shinke; Takehiro Suzuki; Yoichi Takeuchi; Hisato Shima; Yasutoshi Akiyama; Takafumi Toyohara; Chitose Suzuki; Yoshikatu Saiki; Teiji Tominaga; Shigehito Miyagi; Naoki Kawagisihi; Tomoyoshi Soga; Takayoshi Ohkubo; Kenichi Yamamura; Yutaka Imai; Satohiro Masuda; Venkata Sabbisetti; Takaharu Ichimura; David B Mount; Joseph V Bonventre; Sadayoshi Ito; Yoshihisa Tomioka; Kunihiko Itoh; Takaaki Abe
Journal:  J Am Soc Nephrol       Date:  2014-05-15       Impact factor: 10.121

10.  Insoluble mutant SOD1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice.

Authors:  Manuela Basso; Tania Massignan; Giuseppina Samengo; Cristina Cheroni; Silvia De Biasi; Mario Salmona; Caterina Bendotti; Valentina Bonetto
Journal:  J Biol Chem       Date:  2006-08-30       Impact factor: 5.157
View more
  35 in total

1.  Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis.

Authors:  Theodoros Eleftheriadis; Georgios Pissas; Maria Sounidaki; Nikolaos Antoniadis; Georgia Antoniadi; Vassilios Liakopoulos; Ioannis Stefanidis
Journal:  Exp Ther Med       Date:  2016-10-06       Impact factor: 2.447

Review 2.  The Role of Non-coding RNAs in Oncology.

Authors:  Frank J Slack; Arul M Chinnaiyan
Journal:  Cell       Date:  2019-11-14       Impact factor: 41.582

Review 3.  Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology.

Authors:  Heng-Huan Lee; Ying-Nai Wang; Mien-Chie Hung
Journal:  Mol Aspects Med       Date:  2019-03-25

4.  piRNA-like small RNAs target transposable elements in a Clade IV parasitic nematode.

Authors:  Mona Suleiman; Asuka Kounosu; Ben Murcott; Mehmet Dayi; Rebecca Pawluk; Akemi Yoshida; Mark Viney; Taisei Kikuchi; Vicky L Hunt
Journal:  Sci Rep       Date:  2022-06-16       Impact factor: 4.996

Review 5.  Biogenesis and Function of Transfer RNA-Related Fragments (tRFs).

Authors:  Pankaj Kumar; Canan Kuscu; Anindya Dutta
Journal:  Trends Biochem Sci       Date:  2016-06-01       Impact factor: 13.807

6.  5'-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5'-halves.

Authors:  Megumi Shigematsu; Yohei Kirino
Journal:  RNA       Date:  2016-11-22       Impact factor: 4.942

Review 7.  Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.

Authors:  Albert Jeltsch; Ann Ehrenhofer-Murray; Tomasz P Jurkowski; Frank Lyko; Gunter Reuter; Serge Ankri; Wolfgang Nellen; Matthias Schaefer; Mark Helm
Journal:  RNA Biol       Date:  2016-05-27       Impact factor: 4.652

8.  Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Authors:  Christopher J Rhodes; Pavandeep Ghataorhe; John Wharton; Kevin C Rue-Albrecht; Charaka Hadinnapola; Geoffrey Watson; Marta Bleda; Matthias Haimel; Gerry Coghlan; Paul A Corris; Luke S Howard; David G Kiely; Andrew J Peacock; Joanna Pepke-Zaba; Mark R Toshner; S John Wort; J Simon R Gibbs; Allan Lawrie; Stefan Gräf; Nicholas W Morrell; Martin R Wilkins
Journal:  Circulation       Date:  2016-11-21       Impact factor: 29.690

9.  Integrative Analyses of Circulating Small RNAs and Kidney Graft Transcriptome in Transplant Glomerulopathy.

Authors:  Canan Kuscu; Manjari Kiran; Akram Mohammed; Cem Kuscu; Sarthak Satpathy; Aaron Wolen; Elissa Bardhi; Amandeep Bajwa; James D Eason; Daniel Maluf; Valeria Mas; Enver Akalin
Journal:  Int J Mol Sci       Date:  2021-06-09       Impact factor: 5.923

Review 10.  tRNAs taking charge.

Authors:  Jonathan W Cruz; Nancy A Woychik
Journal:  Pathog Dis       Date:  2015-12-10       Impact factor: 3.166
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.