| Literature DB >> 31730848 |
Frank J Slack1, Arul M Chinnaiyan2.
Abstract
For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular activity. An explosion of studies into ncRNA biology has since shown that they represent a diverse and prevalent group of RNAs, including both oncogenic molecules and those that work in a tumor suppressive manner. As a result, hundreds of cancer-focused clinical trials involving ncRNAs as novel biomarkers or therapies have begun and these are likely just the beginning.Entities:
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Year: 2019 PMID： 31730848 PMCID： PMC7347159 DOI： 10.1016/j.cell.2019.10.017
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582