| Literature DB >> 26461095 |
Xiaohui Yan1, Zhongyi Hu2, Yi Feng3, Xiaowen Hu2, Jiao Yuan2, Sihai D Zhao4, Youyou Zhang2, Lu Yang5, Weiwei Shan1, Qun He2, Lingling Fan1, Lana E Kandalaft6, Janos L Tanyi7, Chunsheng Li8, Chao-Xing Yuan9, Dongmei Zhang5, Huiqing Yuan10, Keqin Hua11, Yiling Lu12, Dionyssios Katsaros13, Qihong Huang14, Kathleen Montone15, Yi Fan16, George Coukos17, Jeff Boyd18, Anil K Sood19, Timothy Rebbeck20, Gordon B Mills12, Chi V Dang21, Lin Zhang22.
Abstract
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.Entities:
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Year: 2015 PMID： 26461095 PMCID： PMC4777353 DOI： 10.1016/j.ccell.2015.09.006
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743