Literature DB >> 28616363

Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer.

Andrew J Warburton1,2, David N Boone3,1.   

Abstract

PURPOSE OF REVIEW: The goal of this review was to compare and contrast the results and implications from several recent transcriptomic studies that analyzed the expression of lncRNAs in breast cancer. How many lncRNAs are dysregulated in breast cancer? Do dysregulated lncRNAs contribute to breast cancer etiology? Are lncRNAs viable biomarkers in breast cancer? RECENT
FINDINGS: Transcriptomic profiling of breast cancer tissues, mostly from The Cancer Genome Atlas, identified thousands of long noncoding RNAs that are expressed and dysregulated in breast cancer. The expression of lncRNAs alone can divide patients into molecular subtypes. Subsequent functional studies demonstrated that several of these lncRNAs have important roles in breast cancer cell biology.
SUMMARY: Thousands of lncRNAs are dysregulated in breast cancer that can be developed as biomarkers for prognostic or therapeutic purposes. The reviewed reports provide a roadmap to guide functional studies to discover lncRNAs with critical biological functions relating to breast cancer development and progression.

Entities:  

Keywords:  The Cancer Genome Atlas; biomarkers; breast cancer; long noncoding RNAs; transcriptomics

Year:  2017        PMID： 28616363      PMCID： PMC5467540          DOI： 10.1007/s40139-017-0122-1

Source DB:  PubMed          Journal:  Curr Pathobiol Rep        ISSN： 2167-485X


  125 in total

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Authors:  Ron Edgar; Michael Domrachev; Alex E Lash
Journal:  Nucleic Acids Res       Date:  2002-01-01       Impact factor: 16.971

2.  The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.

Authors:  N Brockdorff; A Ashworth; G F Kay; V M McCabe; D P Norris; P J Cooper; S Swift; S Rastan
Journal:  Cell       Date:  1992-10-30       Impact factor: 41.582

3.  Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells.

Authors:  Séverine Lottin; Eric Adriaenssens; Thierry Dupressoir; Nathalie Berteaux; Claire Montpellier; Jean Coll; Thierry Dugimont; Jean Jacques Curgy
Journal:  Carcinogenesis       Date:  2002-11       Impact factor: 4.944

4.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.

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Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-11       Impact factor: 11.205

5.  Steroid hormones modulate H19 gene expression in both mammary gland and uterus.

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Journal:  Oncogene       Date:  1999-08-05       Impact factor: 9.867

6.  A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex.

Authors:  R B Lanz; N J McKenna; S A Onate; U Albrecht; J Wong; S Y Tsai; M J Tsai; B W O'Malley
Journal:  Cell       Date:  1999-04-02       Impact factor: 41.582

7.  Evidence for evolutionarily conserved secondary structure in the H19 tumor suppressor RNA.

Authors:  V Juan; C Crain; C Wilson
Journal:  Nucleic Acids Res       Date:  2000-03-01       Impact factor: 16.971

8.  Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation.

Authors:  Ilaria T R Cavarretta; Ratna Mukopadhyay; David M Lonard; Lex M Cowsert; C Frank Bennett; Bert W O'Malley; Carolyn L Smith
Journal:  Mol Endocrinol       Date:  2002-02

9.  Molecular portraits of human breast tumours.

Authors:  C M Perou; T Sørlie; M B Eisen; M van de Rijn; S S Jeffrey; C A Rees; J R Pollack; D T Ross; H Johnsen; L A Akslen; O Fluge; A Pergamenschikov; C Williams; S X Zhu; P E Lønning; A L Børresen-Dale; P O Brown; D Botstein
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

10.  Repeated observation of breast tumor subtypes in independent gene expression data sets.

Authors:  Therese Sorlie; Robert Tibshirani; Joel Parker; Trevor Hastie; J S Marron; Andrew Nobel; Shibing Deng; Hilde Johnsen; Robert Pesich; Stephanie Geisler; Janos Demeter; Charles M Perou; Per E Lønning; Patrick O Brown; Anne-Lise Børresen-Dale; David Botstein
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-26       Impact factor: 12.779
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  4 in total

Review 1.  Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2- metastatic breast cancer: a focus on ribociclib.

Authors:  Dumessa Edessa; Mekonnen Sisay
Journal:  Breast Cancer (Dove Med Press)       Date:  2017-12-06

2.  LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells.

Authors:  Aamira Tariq; Qinyu Hao; Qinyu Sun; Deepak K Singh; Mahdieh Jadaliha; Yang Zhang; Neha Chetlangia; Jian Ma; Sarah E Holton; Rohit Bhargava; Ashish Lal; Supriya G Prasanth; Kannanganattu V Prasanth
Journal:  RNA       Date:  2019-11-05       Impact factor: 4.942

3.  Genome-wide analysis of long noncoding RNA expression profile in nasal mucosa with allergic rhinitis.

Authors:  Xian Wei; Man Xu; Chao Wang; Shengjian Fang; Yu Zhang; Weihua Wang
Journal:  BMC Med Genomics       Date:  2021-04-09       Impact factor: 3.063

Review 4.  Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis.

Authors:  Guoku Hu; Fang Niu; Bree A Humburg; Ke Liao; Sunil Bendi; Shannon Callen; Howard S Fox; Shilpa Buch
Journal:  Oncotarget       Date:  2018-01-01
  4 in total

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