Literature DB >> 26454503

Estimation of post-mortem interval: A comparison between cerebrospinal fluid and vitreous humour chemistry.

Rajanikanta Swain1, Adarsh Kumar2, Jyotiranjan Sahoo3, R Lakshmy4, S K Gupta5, D N Bhardwaj6, R M Pandey7.   

Abstract

Accurate estimation of post-mortem interval is of great importance in medico-legal autopsy cases. The present study is intended to compare the accuracy of estimating post-mortem interval from biochemical parameters of vitreous humour and cerebrospinal fluid (CSF). Both the fluids were collected from 100 medico-legal autopsies with known time of death and analysed for potassium, glucose, sodium, calcium, urea and creatinine. The current study found that vitreous humour is a better fluid in comparison to CSF for estimation of post-mortem interval. It is also observed that among the statistically significant parameters in both the fluids, level of potassium and sodium in vitreous humour are giving more accurate results in comparison to their corresponding parameters in CSF while accuracy of glucose is more or less same in both the fluid. Nevertheless potassium concentration in vitreous humour is a single best time honoured parameter to estimate post-mortem interval.
Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Entities:  

Keywords:  Cerebrospinal fluid; Post-mortem interval; Thanatochemistry; Vitreous humour

Mesh:

Substances:

Year:  2015        PMID: 26454503     DOI: 10.1016/j.jflm.2015.09.017

Source DB:  PubMed          Journal:  J Forensic Leg Med        ISSN: 1752-928X            Impact factor:   1.614


  9 in total

1.  An investigation on annular cartilage samples for post-mortem interval estimation using Fourier transform infrared spectroscopy.

Authors:  Zhouru Li; Jiao Huang; Zhenyuan Wang; Ji Zhang; Ping Huang
Journal:  Forensic Sci Med Pathol       Date:  2019-08-01       Impact factor: 2.007

2.  A 1H NMR metabolomic approach for the estimation of the time since death using aqueous humour: an animal model.

Authors:  Emanuela Locci; Matteo Stocchero; Antonio Noto; Alberto Chighine; Luca Natali; Pietro Emanuele Napoli; Roberto Caria; Fabio De-Giorgio; Matteo Nioi; Ernesto d'Aloja
Journal:  Metabolomics       Date:  2019-05-08       Impact factor: 4.290

3.  A preliminary study on early postmortem submersion interval (PMSI) estimation and cause-of-death discrimination based on nontargeted metabolomics and machine learning algorithms.

Authors:  Fu-Yuan Zhang; Lin-Lin Wang; Wen-Wen Dong; Miao Zhang; Dilichati Tash; Xin-Jie Li; Shu-Kui Du; Hao-Miao Yuan; Rui Zhao; Da-Wei Guan
Journal:  Int J Legal Med       Date:  2022-01-31       Impact factor: 2.686

Review 4.  The biochemistry of the vitreous humour in estimating the post-mortem interval-a review of the literature, and use in forensic practice in Galicia (northwestern Spain).

Authors:  Elton Carreiro Da Cunha; Lucía Ordóñez-Mayán; Máximo Lucio Rodríguez Vázquez; Duarte Nuno Vieira; Manuel Febrero-Bande; José Ignacio Muñoz Barús
Journal:  Forensic Sci Med Pathol       Date:  2022-10-22       Impact factor: 2.456

5.  NMR-based metabolomics of human cerebrospinal fluid identifies signature of brain death.

Authors:  Martha E García-Aguilera; Eduardo Rodríguez de San Miguel; Jocelyn Cruz-Pérez; Lucinda Aguirre-Cruz; Christian M Ramirez-Alfaro; Nuria Esturau-Escofet
Journal:  Metabolomics       Date:  2021-04-16       Impact factor: 4.290

6.  Estimation of postmortem interval by vitreous potassium evaluation with a novel fluorescence aptasensor.

Authors:  Yanjun Ding; Xingmei Li; Yadong Guo; Weicheng Duan; Jiang Ling; Lagabaiyla Zha; Jie Yan; Ying Zou; Jifeng Cai
Journal:  Sci Rep       Date:  2017-05-12       Impact factor: 4.379

Review 7.  Postmortem Protein Degradation as a Tool to Estimate the PMI: A Systematic Review.

Authors:  Angela Zissler; Walter Stoiber; Peter Steinbacher; Janine Geissenberger; Fabio C Monticelli; Stefan Pittner
Journal:  Diagnostics (Basel)       Date:  2020-11-26

8.  The radiodensity of cerebrospinal fluid and vitreous humor as indicator of the time since death.

Authors:  Desirée H J L M Koopmanschap; Alireza R Bayat; Bela Kubat; Henri M de Bakker; Mathias W M Prokop; Willemijn M Klein
Journal:  Forensic Sci Med Pathol       Date:  2016-04-27       Impact factor: 2.007

Review 9.  Forensic NMR metabolomics: one more arrow in the quiver.

Authors:  Emanuela Locci; Giovanni Bazzano; Alberto Chighine; Francesco Locco; Ernesto Ferraro; Roberto Demontis; Ernesto d'Aloja
Journal:  Metabolomics       Date:  2020-11-07       Impact factor: 4.290

  9 in total

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