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Literature DB >> 26446953

Companion animals: Translational scientist's new best friends.

Amir Kol¹, Boaz Arzi², Kyriacos A Athanasiou³, Diana L Farmer⁴, Jan A Nolta⁵, Robert B Rebhun², Xinbin Chen⁶, Leigh G Griffiths⁷, Frank J M Verstraete², Christopher J Murphy⁸, Dori L Borjesson⁹.

Abstract

Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 26446953 PMCID： PMC4806851 DOI： 10.1126/scitranslmed.aaa9116

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

63 in total

Review 1. Origin and function of cartilage stem/progenitor cells in osteoarthritis.

Authors: Yangzi Jiang; Rocky S Tuan
Journal: Nat Rev Rheumatol Date: 2014-12-23 Impact factor: 20.543

Review 2. Cranial cruciate ligament disease in dogs: biology versus biomechanics.

Authors: James L Cook
Journal: Vet Surg Date: 2010-04 Impact factor: 1.495

3. Regenerating Mandibular Bone Using rhBMP-2: Part 1-Immediate Reconstruction of Segmental Mandibulectomies.

Authors: Boaz Arzi; Frank J M Verstraete; Daniel J Huey; Derek D Cissell; Kyriacos A Athanasiou
Journal: Vet Surg Date: 2014-01-10 Impact factor: 1.495

4. Feline foamy virus adversely affects feline mesenchymal stem cell culture and expansion: implications for animal model development.

Authors: Boaz Arzi; Amir Kol; Brian Murphy; Naomi J Walker; Joshua A Wood; Kaitlin Clark; Frank J M Verstraete; Dori L Borjesson
Journal: Stem Cells Dev Date: 2014-12-31 Impact factor: 3.272

Review 5. Inflammatory bowel disease in the dog: differences and similarities with humans.

Authors: Matteo Cerquetella; Andrea Spaterna; Fulvio Laus; Beniamino Tesei; Giacomo Rossi; Elisabetta Antonelli; Vincenzo Villanacci; Gabrio Bassotti
Journal: World J Gastroenterol Date: 2010-03-07 Impact factor: 5.742

6. Cancer biology: infectious tumour cells.

Authors: David Dingli; Martin A Nowak
Journal: Nature Date: 2006-09-07 Impact factor: 49.962

7. Limb-sparing treatment for osteosarcoma in dogs.

Authors: S M LaRue; S J Withrow; B E Powers; R H Wrigley; E L Gillette; P D Schwarz; R C Straw; S L Richter
Journal: J Am Vet Med Assoc Date: 1989-12-15 Impact factor: 1.936

Review 8. Translation of new cancer treatments from pet dogs to humans.

Authors: Melissa Paoloni; Chand Khanna
Journal: Nat Rev Cancer Date: 2008-02 Impact factor: 60.716

9. Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage.

Authors: Elizabeth P Murchison; David C Wedge; Ludmil B Alexandrov; Beiyuan Fu; Inigo Martincorena; Zemin Ning; Jose M C Tubio; Emma I Werner; Jan Allen; Andrigo Barboza De Nardi; Edward M Donelan; Gabriele Marino; Ariberto Fassati; Peter J Campbell; Fengtang Yang; Austin Burt; Robin A Weiss; Michael R Stratton
Journal: Science Date: 2014-01-24 Impact factor: 47.728

Review 10. History of narcolepsy at Stanford University.

Authors: Emmanuel J M Mignot
Journal: Immunol Res Date: 2014-05 Impact factor: 2.829

60 in total

1. Quantitative Evaluation of Equine Articular Cartilage Using Cationic Contrast-Enhanced Computed Tomography.

Authors: Brad B Nelson; Rachel C Stewart; Chris E Kawcak; Jonathan D Freedman; Amit N Patwa; Brian D Snyder; Laurie R Goodrich; Mark W Grinstaff
Journal: Cartilage Date: 2018-12-02 Impact factor: 4.634

2. Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs.

Authors: Brian C Leonard; Kathleen A Stewart; Gillian C Shaw; Alyssa L Hoehn; Amelia A Stanley; Christopher J Murphy; Sara M Thomasy
Journal: Cornea Date: 2019-12 Impact factor: 2.651

Review 3. Is Stem Cell Commerce in Small Animal Therapies Scientifically and Morally Justified?

Authors: Luane Lopes Pinheiro; Ana Rita de Lima; Érika Branco
Journal: Stem Cell Rev Rep Date: 2019-08 Impact factor: 5.739

4. Translational Geroscience: From invertebrate models to companion animal and human interventions.

Authors: Mitchell B Lee; Matt Kaeberlein
Journal: Transl Med Aging Date: 2018-08-17

Review 5. Preclinical Animal Models for Temporomandibular Joint Tissue Engineering.

Authors: Alejandro J Almarza; Bryan N Brown; Boaz Arzi; David Faustino Ângelo; William Chung; Stephen F Badylak; Michael Detamore
Journal: Tissue Eng Part B Rev Date: 2018-01-02 Impact factor: 6.389

6. Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Through Multiple Distinct Biochemical Pathways.

Authors: William H Wheat; Lyndah Chow; Jade N Kurihara; Daniel P Regan; Jonathan W Coy; Tracy L Webb; Steven W Dow
Journal: Stem Cells Dev Date: 2016-12-22 Impact factor: 3.272