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Literature DB >> 31140074

Is Stem Cell Commerce in Small Animal Therapies Scientifically and Morally Justified?

Luane Lopes Pinheiro¹, Ana Rita de Lima², Érika Branco².

Abstract

The lack of clear regulations for the use of veterinary stem cells has triggered the commercialization of unproven experimental therapies for companion animal diseases. Adult stem cells have complex biological characteristics that are directly related to the therapeutic application, but several questions remain to be answered. In order to regulate the use of these cells, well-conducted, controlled scientific studies that generate high-quality data should be performed, in order to assess the efficacy and safety of the intended treatment. This paper discusses the scientific challenges of mesenchymal stem cell therapy in veterinary regenerative medicine, and reviews published trials of adipose-tissue-derived stem cells in companion animal diseases that spontaneously occur.

Keywords: Adipose-derived stem cell (ASC); Cat; Cell therapy; Dog; Small animal

Year: 2019 PMID： 31140074 DOI： 10.1007/s12015-019-09898-z

Source DB: PubMed Journal: Stem Cell Rev Rep ISSN： 2629-3277 Impact factor: 5.739

102 in total

Review 1. Out of Eden: stem cells and their niches.

Authors: F M Watt; B L Hogan
Journal: Science Date: 2000-02-25 Impact factor: 47.728

Review 2. Mesenchymal stem cells as trophic mediators.

Authors: Arnold I Caplan; James E Dennis
Journal: J Cell Biochem Date: 2006-08-01 Impact factor: 4.429

3. Mesenchymal stem cells reside in virtually all post-natal organs and tissues.

Authors: Lindolfo da Silva Meirelles; Pedro Cesar Chagastelles; Nance Beyer Nardi
Journal: J Cell Sci Date: 2006-05-09 Impact factor: 5.285

4. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

Authors: M Dominici; K Le Blanc; I Mueller; I Slaper-Cortenbach; Fc Marini; Ds Krause; Rj Deans; A Keating; Dj Prockop; Em Horwitz
Journal: Cytotherapy Date: 2006 Impact factor: 5.414

1. Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial.

Authors: Sohyun Kim; Lindsay Elam; Valerie Johnson; Ann Hess; Tracy Webb; Steven Dow; Felix Duerr
Journal: Front Vet Sci Date: 2022-06-07

1 in total

Is Stem Cell Commerce in Small Animal Therapies Scientifically and Morally Justified?

Review 1. Out of Eden: stem cells and their niches.

Review 2. Mesenchymal stem cells as trophic mediators.

3. Mesenchymal stem cells reside in virtually all post-natal organs and tissues.

4. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

Review 5. Adipose-derived stem cells for regenerative medicine.

6. Multilineage cells from human adipose tissue: implications for cell-based therapies.

7. Comparison of osteogenic potentials of visceral and subcutaneous adipose-derived cells of rabbits.

8. Mesenchymal stem cells from rat visceral fat exhibit multipotential differentiation in vitro.

9. Differentiation of stromal-vascular cells isolated from canine adipose tissues in primary culture.

10. Mesenchymal stem cells avoid allogeneic rejection.

1. Intra-Articular Injections of Allogeneic Mesenchymal Stromal Cells vs. High Molecular Weight Hyaluronic Acid in Dogs With Osteoarthritis: Exploratory Data From a Double-Blind, Randomized, Prospective Clinical Trial.