| Literature DB >> 26426971 |
Thomas W Winkler1, Anne E Justice2, Mariaelisa Graff2, Llilda Barata3, Mary F Feitosa3, Su Chu4, Jacek Czajkowski3, Tõnu Esko5, Tove Fall6, Tuomas O Kilpeläinen7, Yingchang Lu8, Reedik Mägi9, Evelin Mihailov10, Tune H Pers11, Sina Rüeger12, Alexander Teumer13, Georg B Ehret14, Teresa Ferreira15, Nancy L Heard-Costa16, Juha Karjalainen17, Vasiliki Lagou18, Anubha Mahajan15, Michael D Neinast19, Inga Prokopenko20, Jeannette Simino21, Tanya M Teslovich4, Rick Jansen22, Harm-Jan Westra23, Charles C White24, Devin Absher25, Tarunveer S Ahluwalia26, Shafqat Ahmad27, Eva Albrecht28, Alexessander Couto Alves29, Jennifer L Bragg-Gresham4, Anton J M de Craen30, Joshua C Bis31, Amélie Bonnefond32, Gabrielle Boucher33, Gemma Cadby34, Yu-Ching Cheng35, Charleston W K Chiang36, Graciela Delgado37, Ayse Demirkan38, Nicole Dueker39, Niina Eklund40, Gudny Eiriksdottir41, Joel Eriksson42, Bjarke Feenstra43, Krista Fischer10, Francesca Frau44, Tessel E Galesloot45, Frank Geller43, Anuj Goel46, Mathias Gorski47, Tanja B Grammer37, Stefan Gustafsson6, Saskia Haitjema48, Jouke-Jan Hottenga49, Jennifer E Huffman50, Anne U Jackson4, Kevin B Jacobs51, Åsa Johansson52, Marika Kaakinen53, Marcus E Kleber37, Jari Lahti54, Irene Mateo Leach55, Benjamin Lehne56, Youfang Liu57, Ken Sin Lo33, Mattias Lorentzon42, Jian'an Luan58, Pamela A F Madden59, Massimo Mangino60, Barbara McKnight61, Carolina Medina-Gomez62, Keri L Monda63, May E Montasser64, Gabriele Müller65, Martina Müller-Nurasyid66, Ilja M Nolte67, Kalliope Panoutsopoulou68, Laura Pascoe69, Lavinia Paternoster70, Nigel W Rayner71, Frida Renström27, Federica Rizzi44, Lynda M Rose72, Kathy A Ryan64, Perttu Salo73, Serena Sanna74, Hubert Scharnagl75, Jianxin Shi76, Albert Vernon Smith77, Lorraine Southam78, Alena Stančáková79, Valgerdur Steinthorsdottir80, Rona J Strawbridge81, Yun Ju Sung21, Ioanna Tachmazidou68, Toshiko Tanaka82, Gudmar Thorleifsson80, Stella Trompet83, Natalia Pervjakova84, Jonathan P Tyrer85, Liesbeth Vandenput42, Sander W van der Laan48, Nathalie van der Velde86, Jessica van Setten87, Jana V van Vliet-Ostaptchouk88, Niek Verweij55, Efthymia Vlachopoulou89, Lindsay L Waite25, Sophie R Wang90, Zhaoming Wang51, Sarah H Wild91, Christina Willenborg92, James F Wilson93, Andrew Wong94, Jian Yang95, Loïc Yengo32, Laura M Yerges-Armstrong64, Lei Yu96, Weihua Zhang97, Jing Hua Zhao58, Ehm A Andersson98, Stephan J L Bakker99, Damiano Baldassarre100, Karina Banasik98, Matteo Barcella101, Cristina Barlassina101, Claire Bellis102, Paola Benaglio103, John Blangero104, Matthias Blüher105, Fabrice Bonnet106, Lori L Bonnycastle107, Heather A Boyd43, Marcel Bruinenberg108, Aron S Buchman96, Harry Campbell93, Yii-Der Ida Chen109, Peter S Chines107, Simone Claudi-Boehm110, John Cole111, Francis S Collins107, Eco J C de Geus112, Lisette C P G M de Groot113, Maria Dimitriou114, Jubao Duan115, Stefan Enroth52, Elodie Eury32, Aliki-Eleni Farmaki116, Nita G Forouhi58, Nele Friedrich117, Pablo V Gejman115, Bruna Gigante118, Nicola Glorioso119, Alan S Go120, Omri Gottesman121, Jürgen Gräßler122, Harald Grallert123, Niels Grarup98, Yu-Mei Gu124, Linda Broer125, Annelies C Ham125, Torben Hansen126, Tamara B Harris127, Catharina A Hartman128, Maija Hassinen129, Nicholas Hastie130, Andrew T Hattersley131, Andrew C Heath59, Anjali K Henders132, Dena Hernandez133, Hans Hillege55, Oddgeir Holmen134, Kees G Hovingh135, Jennie Hui136, Lise L Husemoen137, Nina Hutri-Kähönen138, Pirro G Hysi60, Thomas Illig139, Philip L De Jager140, Shapour Jalilzadeh46, Torben Jørgensen141, J Wouter Jukema142, Markus Juonala143, Stavroula Kanoni144, Maria Karaleftheri145, Kay Tee Khaw146, Leena Kinnunen147, Steven J Kittner111, Wolfgang Koenig148, Ivana Kolcic149, Peter Kovacs150, Nikolaj T Krarup98, Wolfgang Kratzer110, Janine Krüger151, Diana Kuh94, Meena Kumari152, Theodosios Kyriakou46, Claudia Langenberg153, Lars Lannfelt154, Chiara Lanzani155, Vaneet Lotay156, Lenore J Launer157, Karin Leander118, Jaana Lindström158, Allan Linneberg159, Yan-Ping Liu124, Stéphane Lobbens32, Robert Luben160, Valeriya Lyssenko161, Satu Männistö162, Patrik K Magnusson163, Wendy L McArdle164, Cristina Menni60, Sigrun Merger110, Lili Milani10, Grant W Montgomery132, Andrew P Morris165, Narisu Narisu107, Mari Nelis10, Ken K Ong166, Aarno Palotie167, Louis Pérusse168, Irene Pichler169, Maria G Pilia74, Anneli Pouta170, Myriam Rheinberger171, Rasmus Ribel-Madsen98, Marcus Richards94, Kenneth M Rice172, Treva K Rice173, Carlo Rivolta174, Veikko Salomaa162, Alan R Sanders115, Mark A Sarzynski175, Salome Scholtens67, Robert A Scott58, William R Scott97, Sylvain Sebert176, Sebanti Sengupta4, Bengt Sennblad177, Thomas Seufferlein110, Angela Silveira81, P Eline Slagboom178, Jan H Smit22, Thomas H Sparsø98, Kathleen Stirrups144, Ronald P Stolk67, Heather M Stringham4, Morris A Swertz17, Amy J Swift107, Ann-Christine Syvänen179, Sian-Tsung Tan180, Barbara Thorand181, Anke Tönjes182, Angelo Tremblay183, Emmanouil Tsafantakis184, Peter J van der Most67, Uwe Völker185, Marie-Claude Vohl186, Judith M Vonk67, Melanie Waldenberger187, Ryan W Walker8, Roman Wennauer188, Elisabeth Widén189, Gonneke Willemsen49, Tom Wilsgaard190, Alan F Wright130, M Carola Zillikens191, Suzanne C van Dijk125, Natasja M van Schoor192, Folkert W Asselbergs193, Paul I W de Bakker194, Jacques S Beckmann195, John Beilby196, David A Bennett96, Richard N Bergman197, Sven Bergmann198, Carsten A Böger171, Bernhard O Boehm199, Eric Boerwinkle200, Dorret I Boomsma49, Stefan R Bornstein201, Erwin P Bottinger121, Claude Bouchard175, John C Chambers202, Stephen J Chanock203, Daniel I Chasman204, Francesco Cucca205, Daniele Cusi206, George Dedoussis116, Jeanette Erdmann92, Johan G Eriksson207, Denis A Evans208, Ulf de Faire118, Martin Farrall209, Luigi Ferrucci82, Ian Ford210, Lude Franke211, Paul W Franks212, Philippe Froguel32, Ron T Gansevoort99, Christian Gieger213, Henrik Grönberg163, Vilmundur Gudnason77, Ulf Gyllensten52, Per Hall163, Anders Hamsten214, Pim van der Harst215, Caroline Hayward130, Markku Heliövaara147, Christian Hengstenberg216, Andrew A Hicks169, Aroon Hingorani217, Albert Hofman218, Frank Hu219, Heikki V Huikuri220, Kristian Hveem134, Alan L James221, Joanne M Jordan57, Antti Jula162, Mika Kähönen222, Eero Kajantie223, Sekar Kathiresan224, Lambertus A L M Kiemeney225, Mika Kivimaki152, Paul B Knekt226, Heikki A Koistinen227, Jaspal S Kooner228, Seppo Koskinen147, Johanna Kuusisto79, Winfried Maerz229, Nicholas G Martin132, Markku Laakso79, Timo A Lakka230, Terho Lehtimäki231, Guillaume Lettre232, Douglas F Levinson233, Lars Lind234, Marja-Liisa Lokki89, Pekka Mäntyselkä235, Mads Melbye236, Andres Metspalu10, Braxton D Mitchell237, Frans L Moll238, Jeffrey C Murray239, Arthur W Musk240, Markku S Nieminen241, Inger Njølstad190, Claes Ohlsson42, Albertine J Oldehinkel242, Ben A Oostra38, Lyle J Palmer243, James S Pankow244, Gerard Pasterkamp48, Nancy L Pedersen163, Oluf Pedersen98, Brenda W Penninx22, Markus Perola245, Annette Peters187, Ozren Polašek246, Peter P Pramstaller247, Bruce M Psaty248, Lu Qi219, Thomas Quertermous249, Olli T Raitakari250, Tuomo Rankinen175, Rainer Rauramaa251, Paul M Ridker204, John D Rioux232, Fernando Rivadeneira62, Jerome I Rotter109, Igor Rudan93, Hester M den Ruijter48, Juha Saltevo252, Naveed Sattar253, Heribert Schunkert216, Peter E H Schwarz201, Alan R Shuldiner254, Juha Sinisalo241, Harold Snieder67, Thorkild I A Sørensen255, Tim D Spector60, Jan A Staessen256, Bandinelli Stefania257, Unnur Thorsteinsdottir258, Michael Stumvoll105, Jean-Claude Tardif232, Elena Tremoli100, Jaakko Tuomilehto259, André G Uitterlinden62, Matti Uusitupa260, André L M Verbeek45, Sita H Vermeulen261, Jorma S Viikari262, Veronique Vitart130, Henry Völzke263, Peter Vollenweider264, Gérard Waeber264, Mark Walker265, Henri Wallaschofski266, Nicholas J Wareham58, Hugh Watkins46, Eleftheria Zeggini68, Aravinda Chakravarti267, Deborah J Clegg19, L Adrienne Cupples268, Penny Gordon-Larsen269, Cashell E Jaquish270, D C Rao271, Goncalo R Abecasis4, Themistocles L Assimes249, Inês Barroso272, Sonja I Berndt273, Michael Boehnke4, Panos Deloukas274, Caroline S Fox275, Leif C Groop276, David J Hunter277, Erik Ingelsson278, Robert C Kaplan279, Mark I McCarthy280, Karen L Mohlke281, Jeffrey R O'Connell64, David Schlessinger157, David P Strachan282, Kari Stefansson258, Cornelia M van Duijn283, Joel N Hirschhorn284, Cecilia M Lindgren285, Iris M Heid286, Kari E North287, Ingrid B Borecki3, Zoltán Kutalik288, Ruth J F Loos289.
Abstract
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Entities:
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Year: 2015 PMID： 26426971 PMCID： PMC4591371 DOI： 10.1371/journal.pgen.1005378
Source DB: PubMed Journal: PLoS Genet ISSN： 1553-7390 Impact factor: 5.917