Literature DB >> 27573685

CREBRF variant increases obesity risk and protects against diabetes in Samoans.

Ruth J F Loos1.   

Abstract

A genome-wide study in Samoans has identified a protein-altering variant (p.Arg475Gln) in CREBRF as being associated with 1.3-fold increased risk of obesity and, intriguingly, 1.6-fold decreased risk of type 2 diabetes. This variant, which is common among Samoans (minor allele frequency = 26%) but extremely rare in other populations, promotes fat storage and reduces energy use in cellular models.

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Year:  2016        PMID： 27573685     DOI： 10.1038/ng.3653

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study.

Authors:  Nicola L Hawley; Ryan L Minster; Daniel E Weeks; Satupaitea Viali; Muagututia Sefuiva Reupena; Guangyun Sun; Hong Cheng; Ranjan Deka; Stephen T Mcgarvey
Journal:  Am J Hum Biol       Date:  2014-05-05       Impact factor: 1.937

2.  Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis.

Authors:  J R Speakman
Journal:  Int J Obes (Lond)       Date:  2008-10-14       Impact factor: 5.095

3.  A thrifty variant in CREBRF strongly influences body mass index in Samoans.

Authors:  Ryan L Minster; Nicola L Hawley; Chi-Ting Su; Guangyun Sun; Erin E Kershaw; Hong Cheng; Olive D Buhule; Jerome Lin; Muagututi'a Sefuiva Reupena; Satupa'itea Viali; John Tuitele; Take Naseri; Zsolt Urban; Ranjan Deka; Daniel E Weeks; Stephen T McGarvey
Journal:  Nat Genet       Date:  2016-07-25       Impact factor: 38.330

4.  Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:  Tuomas O Kilpeläinen; M Carola Zillikens; Alena Stančákova; Francis M Finucane; Janina S Ried; Claudia Langenberg; Weihua Zhang; Jacques S Beckmann; Jian'an Luan; Liesbeth Vandenput; Unnur Styrkarsdottir; Yanhua Zhou; Albert Vernon Smith; Jing-Hua Zhao; Najaf Amin; Sailaja Vedantam; So-Youn Shin; Talin Haritunians; Mao Fu; Mary F Feitosa; Meena Kumari; Bjarni V Halldorsson; Emmi Tikkanen; Massimo Mangino; Caroline Hayward; Ci Song; Alice M Arnold; Yurii S Aulchenko; Ben A Oostra; Harry Campbell; L Adrienne Cupples; Kathryn E Davis; Angela Döring; Gudny Eiriksdottir; Karol Estrada; José Manuel Fernández-Real; Melissa Garcia; Christian Gieger; Nicole L Glazer; Candace Guiducci; Albert Hofman; Steve E Humphries; Bo Isomaa; Leonie C Jacobs; Antti Jula; David Karasik; Magnus K Karlsson; Kay-Tee Khaw; Lauren J Kim; Mika Kivimäki; Norman Klopp; Brigitte Kühnel; Johanna Kuusisto; Yongmei Liu; Osten Ljunggren; Mattias Lorentzon; Robert N Luben; Barbara McKnight; Dan Mellström; Braxton D Mitchell; Vincent Mooser; José Maria Moreno; Satu Männistö; Jeffery R O'Connell; Laura Pascoe; Leena Peltonen; Belén Peral; Markus Perola; Bruce M Psaty; Veikko Salomaa; David B Savage; Robert K Semple; Tatjana Skaric-Juric; Gunnar Sigurdsson; Kijoung S Song; Timothy D Spector; Ann-Christine Syvänen; Philippa J Talmud; Gudmar Thorleifsson; Unnur Thorsteinsdottir; André G Uitterlinden; Cornelia M van Duijn; Antonio Vidal-Puig; Sarah H Wild; Alan F Wright; Deborah J Clegg; Eric Schadt; James F Wilson; Igor Rudan; Samuli Ripatti; Ingrid B Borecki; Alan R Shuldiner; Erik Ingelsson; John-Olov Jansson; Robert C Kaplan; Vilmundur Gudnason; Tamara B Harris; Leif Groop; Douglas P Kiel; Fernando Rivadeneira; Mark Walker; Inês Barroso; Peter Vollenweider; Gérard Waeber; John C Chambers; Jaspal S Kooner; Nicole Soranzo; Joel N Hirschhorn; Kari Stefansson; H-Erich Wichmann; Claes Ohlsson; Stephen O'Rahilly; Nicholas J Wareham; Elizabeth K Speliotes; Caroline S Fox; Markku Laakso; Ruth J F Loos
Journal:  Nat Genet       Date:  2011-06-26       Impact factor: 38.330

5.  The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:  Thomas W Winkler; Anne E Justice; Mariaelisa Graff; Llilda Barata; Mary F Feitosa; Su Chu; Jacek Czajkowski; Tõnu Esko; Tove Fall; Tuomas O Kilpeläinen; Yingchang Lu; Reedik Mägi; Evelin Mihailov; Tune H Pers; Sina Rüeger; Alexander Teumer; Georg B Ehret; Teresa Ferreira; Nancy L Heard-Costa; Juha Karjalainen; Vasiliki Lagou; Anubha Mahajan; Michael D Neinast; Inga Prokopenko; Jeannette Simino; Tanya M Teslovich; Rick Jansen; Harm-Jan Westra; Charles C White; Devin Absher; Tarunveer S Ahluwalia; Shafqat Ahmad; Eva Albrecht; Alexessander Couto Alves; Jennifer L Bragg-Gresham; Anton J M de Craen; Joshua C Bis; Amélie Bonnefond; Gabrielle Boucher; Gemma Cadby; Yu-Ching Cheng; Charleston W K Chiang; Graciela Delgado; Ayse Demirkan; Nicole Dueker; Niina Eklund; Gudny Eiriksdottir; Joel Eriksson; Bjarke Feenstra; Krista Fischer; Francesca Frau; Tessel E Galesloot; Frank Geller; Anuj Goel; Mathias Gorski; Tanja B Grammer; Stefan Gustafsson; Saskia Haitjema; Jouke-Jan Hottenga; Jennifer E Huffman; Anne U Jackson; Kevin B Jacobs; Åsa Johansson; Marika Kaakinen; Marcus E Kleber; Jari Lahti; Irene Mateo Leach; Benjamin Lehne; Youfang Liu; Ken Sin Lo; Mattias Lorentzon; Jian'an Luan; Pamela A F Madden; Massimo Mangino; Barbara McKnight; Carolina Medina-Gomez; Keri L Monda; May E Montasser; Gabriele Müller; Martina Müller-Nurasyid; Ilja M Nolte; Kalliope Panoutsopoulou; Laura Pascoe; Lavinia Paternoster; Nigel W Rayner; Frida Renström; Federica Rizzi; Lynda M Rose; Kathy A Ryan; Perttu Salo; Serena Sanna; Hubert Scharnagl; Jianxin Shi; Albert Vernon Smith; Lorraine Southam; Alena Stančáková; Valgerdur Steinthorsdottir; Rona J Strawbridge; Yun Ju Sung; Ioanna Tachmazidou; Toshiko Tanaka; Gudmar Thorleifsson; Stella Trompet; Natalia Pervjakova; Jonathan P Tyrer; Liesbeth Vandenput; Sander W van der Laan; Nathalie van der Velde; Jessica van Setten; Jana V van Vliet-Ostaptchouk; Niek Verweij; Efthymia Vlachopoulou; Lindsay L Waite; Sophie R Wang; Zhaoming Wang; Sarah H Wild; Christina Willenborg; James F Wilson; Andrew Wong; Jian Yang; Loïc Yengo; Laura M Yerges-Armstrong; Lei Yu; Weihua Zhang; Jing Hua Zhao; Ehm A Andersson; Stephan J L Bakker; Damiano Baldassarre; Karina Banasik; Matteo Barcella; Cristina Barlassina; Claire Bellis; Paola Benaglio; John Blangero; Matthias Blüher; Fabrice Bonnet; Lori L Bonnycastle; Heather A Boyd; Marcel Bruinenberg; Aron S Buchman; Harry Campbell; Yii-Der Ida Chen; Peter S Chines; Simone Claudi-Boehm; John Cole; Francis S Collins; Eco J C de Geus; Lisette C P G M de Groot; Maria Dimitriou; Jubao Duan; Stefan Enroth; Elodie Eury; Aliki-Eleni Farmaki; Nita G Forouhi; Nele Friedrich; Pablo V Gejman; Bruna Gigante; Nicola Glorioso; Alan S Go; Omri Gottesman; Jürgen Gräßler; Harald Grallert; Niels Grarup; Yu-Mei Gu; Linda Broer; Annelies C Ham; Torben Hansen; Tamara B Harris; Catharina A Hartman; Maija Hassinen; Nicholas Hastie; Andrew T Hattersley; Andrew C Heath; Anjali K Henders; Dena Hernandez; Hans Hillege; Oddgeir Holmen; Kees G Hovingh; Jennie Hui; Lise L Husemoen; Nina Hutri-Kähönen; Pirro G Hysi; Thomas Illig; Philip L De Jager; Shapour Jalilzadeh; Torben Jørgensen; J Wouter Jukema; Markus Juonala; Stavroula Kanoni; Maria Karaleftheri; Kay Tee Khaw; Leena Kinnunen; Steven J Kittner; Wolfgang Koenig; Ivana Kolcic; Peter Kovacs; Nikolaj T Krarup; Wolfgang Kratzer; Janine Krüger; Diana Kuh; Meena Kumari; Theodosios Kyriakou; Claudia Langenberg; Lars Lannfelt; Chiara Lanzani; Vaneet Lotay; Lenore J Launer; Karin Leander; Jaana Lindström; Allan Linneberg; Yan-Ping Liu; Stéphane Lobbens; Robert Luben; Valeriya Lyssenko; Satu Männistö; Patrik K Magnusson; Wendy L McArdle; Cristina Menni; Sigrun Merger; Lili Milani; Grant W Montgomery; Andrew P Morris; Narisu Narisu; Mari Nelis; Ken K Ong; Aarno Palotie; Louis Pérusse; Irene Pichler; Maria G Pilia; Anneli Pouta; Myriam Rheinberger; Rasmus Ribel-Madsen; Marcus Richards; Kenneth M Rice; Treva K Rice; Carlo Rivolta; Veikko Salomaa; Alan R Sanders; Mark A Sarzynski; Salome Scholtens; Robert A Scott; William R Scott; Sylvain Sebert; Sebanti Sengupta; Bengt Sennblad; Thomas Seufferlein; Angela Silveira; P Eline Slagboom; Jan H Smit; Thomas H Sparsø; Kathleen Stirrups; Ronald P Stolk; Heather M Stringham; Morris A Swertz; Amy J Swift; Ann-Christine Syvänen; Sian-Tsung Tan; Barbara Thorand; Anke Tönjes; Angelo Tremblay; Emmanouil Tsafantakis; Peter J van der Most; Uwe Völker; Marie-Claude Vohl; Judith M Vonk; Melanie Waldenberger; Ryan W Walker; Roman Wennauer; Elisabeth Widén; Gonneke Willemsen; Tom Wilsgaard; Alan F Wright; M Carola Zillikens; Suzanne C van Dijk; Natasja M van Schoor; Folkert W Asselbergs; Paul I W de Bakker; Jacques S Beckmann; John Beilby; David A Bennett; Richard N Bergman; Sven Bergmann; Carsten A Böger; Bernhard O Boehm; Eric Boerwinkle; Dorret I Boomsma; Stefan R Bornstein; Erwin P Bottinger; Claude Bouchard; John C Chambers; Stephen J Chanock; Daniel I Chasman; Francesco Cucca; Daniele Cusi; George Dedoussis; Jeanette Erdmann; Johan G Eriksson; Denis A Evans; Ulf de Faire; Martin Farrall; Luigi Ferrucci; Ian Ford; Lude Franke; Paul W Franks; Philippe Froguel; Ron T Gansevoort; Christian Gieger; Henrik Grönberg; Vilmundur Gudnason; Ulf Gyllensten; Per Hall; Anders Hamsten; Pim van der Harst; Caroline Hayward; Markku Heliövaara; Christian Hengstenberg; Andrew A Hicks; Aroon Hingorani; Albert Hofman; Frank Hu; Heikki V Huikuri; Kristian Hveem; Alan L James; Joanne M Jordan; Antti Jula; Mika Kähönen; Eero Kajantie; Sekar Kathiresan; Lambertus A L M Kiemeney; Mika Kivimaki; Paul B Knekt; Heikki A Koistinen; Jaspal S Kooner; Seppo Koskinen; Johanna Kuusisto; Winfried Maerz; Nicholas G Martin; Markku Laakso; Timo A Lakka; Terho Lehtimäki; Guillaume Lettre; Douglas F Levinson; Lars Lind; Marja-Liisa Lokki; Pekka Mäntyselkä; Mads Melbye; Andres Metspalu; Braxton D Mitchell; Frans L Moll; Jeffrey C Murray; Arthur W Musk; Markku S Nieminen; Inger Njølstad; Claes Ohlsson; Albertine J Oldehinkel; Ben A Oostra; Lyle J Palmer; James S Pankow; Gerard Pasterkamp; Nancy L Pedersen; Oluf Pedersen; Brenda W Penninx; Markus Perola; Annette Peters; Ozren Polašek; Peter P Pramstaller; Bruce M Psaty; Lu Qi; Thomas Quertermous; Olli T Raitakari; Tuomo Rankinen; Rainer Rauramaa; Paul M Ridker; John D Rioux; Fernando Rivadeneira; Jerome I Rotter; Igor Rudan; Hester M den Ruijter; Juha Saltevo; Naveed Sattar; Heribert Schunkert; Peter E H Schwarz; Alan R Shuldiner; Juha Sinisalo; Harold Snieder; Thorkild I A Sørensen; Tim D Spector; Jan A Staessen; Bandinelli Stefania; Unnur Thorsteinsdottir; Michael Stumvoll; Jean-Claude Tardif; Elena Tremoli; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; André L M Verbeek; Sita H Vermeulen; Jorma S Viikari; Veronique Vitart; Henry Völzke; Peter Vollenweider; Gérard Waeber; Mark Walker; Henri Wallaschofski; Nicholas J Wareham; Hugh Watkins; Eleftheria Zeggini; Aravinda Chakravarti; Deborah J Clegg; L Adrienne Cupples; Penny Gordon-Larsen; Cashell E Jaquish; D C Rao; Goncalo R Abecasis; Themistocles L Assimes; Inês Barroso; Sonja I Berndt; Michael Boehnke; Panos Deloukas; Caroline S Fox; Leif C Groop; David J Hunter; Erik Ingelsson; Robert C Kaplan; Mark I McCarthy; Karen L Mohlke; Jeffrey R O'Connell; David Schlessinger; David P Strachan; Kari Stefansson; Cornelia M van Duijn; Joel N Hirschhorn; Cecilia M Lindgren; Iris M Heid; Kari E North; Ingrid B Borecki; Zoltán Kutalik; Ruth J F Loos
Journal:  PLoS Genet       Date:  2015-10-01       Impact factor: 5.917

6.  A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Authors:  Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
Journal:  Science       Date:  2007-04-12       Impact factor: 47.728

7.  Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.

Authors:  Hanieh Yaghootkar; Robert A Scott; Charles C White; Weihua Zhang; Elizabeth Speliotes; Patricia B Munroe; Georg B Ehret; Joshua C Bis; Caroline S Fox; Mark Walker; Ingrid B Borecki; Joshua W Knowles; Laura Yerges-Armstrong; Claes Ohlsson; John R B Perry; John C Chambers; Jaspal S Kooner; Nora Franceschini; Claudia Langenberg; Marie-France Hivert; Zari Dastani; J Brent Richards; Robert K Semple; Timothy M Frayling
Journal:  Diabetes       Date:  2014-07-21       Impact factor: 9.337

8.  Analysis of protein-coding genetic variation in 60,706 humans.

Authors:  Monkol Lek; Konrad J Karczewski; Eric V Minikel; Kaitlin E Samocha; Eric Banks; Timothy Fennell; Anne H O'Donnell-Luria; James S Ware; Andrew J Hill; Beryl B Cummings; Taru Tukiainen; Daniel P Birnbaum; Jack A Kosmicki; Laramie E Duncan; Karol Estrada; Fengmei Zhao; James Zou; Emma Pierce-Hoffman; Joanne Berghout; David N Cooper; Nicole Deflaux; Mark DePristo; Ron Do; Jason Flannick; Menachem Fromer; Laura Gauthier; Jackie Goldstein; Namrata Gupta; Daniel Howrigan; Adam Kiezun; Mitja I Kurki; Ami Levy Moonshine; Pradeep Natarajan; Lorena Orozco; Gina M Peloso; Ryan Poplin; Manuel A Rivas; Valentin Ruano-Rubio; Samuel A Rose; Douglas M Ruderfer; Khalid Shakir; Peter D Stenson; Christine Stevens; Brett P Thomas; Grace Tiao; Maria T Tusie-Luna; Ben Weisburd; Hong-Hee Won; Dongmei Yu; David M Altshuler; Diego Ardissino; Michael Boehnke; John Danesh; Stacey Donnelly; Roberto Elosua; Jose C Florez; Stacey B Gabriel; Gad Getz; Stephen J Glatt; Christina M Hultman; Sekar Kathiresan; Markku Laakso; Steven McCarroll; Mark I McCarthy; Dermot McGovern; Ruth McPherson; Benjamin M Neale; Aarno Palotie; Shaun M Purcell; Danish Saleheen; Jeremiah M Scharf; Pamela Sklar; Patrick F Sullivan; Jaakko Tuomilehto; Ming T Tsuang; Hugh C Watkins; James G Wilson; Mark J Daly; Daniel G MacArthur
Journal:  Nature       Date:  2016-08-18       Impact factor: 49.962

Review 9.  Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants.

Authors: 
Journal:  Lancet       Date:  2016-04-02       Impact factor: 79.321

10.  Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.

Authors: 
Journal:  Lancet       Date:  2016-04-06       Impact factor: 79.321
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  6 in total

Review 1.  The Genetic Basis of Metabolic Disease.

Authors:  Inês Barroso; Mark I McCarthy
Journal:  Cell       Date:  2019-03-21       Impact factor: 41.582

2.  The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.

Authors:  Hannah J Burden; Shannon Adams; Braydon Kulatea; Morag Wright-McNaughton; Danielle Sword; Jennifer J Ormsbee; Conor Watene-O'Sullivan; Tony R Merriman; Jennifer L Knopp; J Geoffrey Chase; Jeremy D Krebs; Rosemary M Hall; Lindsay D Plank; Rinki Murphy; Peter R Shepherd; Troy L Merry
Journal:  Diabetologia       Date:  2021-08-21       Impact factor: 10.122

3.  Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program.

Authors:  Alyna T Khan; Stephanie M Gogarten; Caitlin P McHugh; Adrienne M Stilp; Tamar Sofer; Michael L Bowers; Quenna Wong; L Adrienne Cupples; Bertha Hidalgo; Andrew D Johnson; Merry-Lynn N McDonald; Stephen T McGarvey; Matthew R G Taylor; Stephanie M Fullerton; Matthew P Conomos; Sarah C Nelson
Journal:  Cell Genom       Date:  2022-07-26

4.  Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.

Authors:  Mohanraj Krishnan; Tanya J Major; Ruth K Topless; Ofa Dewes; Lennex Yu; John M D Thompson; Lesley McCowan; Janak de Zoysa; Lisa K Stamp; Nicola Dalbeth; Jennie Harré Hindmarsh; Nuku Rapana; Ranjan Deka; Winston W H Eng; Daniel E Weeks; Ryan L Minster; Stephen T McGarvey; Satupa'itea Viali; Take Naseri; Muagututi'a Sefuiva Reupena; Phillip Wilcox; David Grattan; Peter R Shepherd; Andrew N Shelling; Rinki Murphy; Tony R Merriman
Journal:  Diabetologia       Date:  2018-05-02       Impact factor: 10.122

5.  A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity.

Authors:  Li Liu; Qianrui Fan; Feng Zhang; Xiong Guo; Xiao Liang; Yanan Du; Ping Li; Yan Wen; Jingcan Hao; Wenyu Wang; Awen He
Journal:  Biomed Res Int       Date:  2018-05-08       Impact factor: 3.411

6.  Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools.

Authors:  Keolu Fox; Kartik Lakshmi Rallapalli; Alexis C Komor
Journal:  Genes (Basel)       Date:  2020-01-12       Impact factor: 4.096
  6 in total

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