Literature DB >> 26413210

GENETIC ANALYSIS OF STRUCTURAL BRAIN CONNECTIVITY USING DICCCOL MODELS OF DIFFUSION MRI IN 522 TWINS.

Dajiang Zhu1, Liang Zhan1, Joshua Faskowitz1, Madelaine Daianu1, Neda Jahanshad1, Greig I de Zubicaray2, Katie L McMahon3, Nicholas G Martin4, Margaret J Wright4, Paul M Thompson1.   

Abstract

Genetic and environmental factors affect white matter connectivity in the normal brain, and they also influence diseases in which brain connectivity is altered. Little is known about genetic influences on brain connectivity, despite wide variations in the brain's neural pathways. Here we applied the "DICCCOL" framework to analyze structural connectivity, in 261 twin pairs (522 participants, mean age: 21.8 y ± 2.7SD). We encoded connectivity patterns by projecting the white matter (WM) bundles of all "DICCCOLs" as a tracemap (TM). Next we fitted an A/C/E structural equation model to estimate additive genetic (A), common environmental (C), and unique environmental/error (E) components of the observed variations in brain connectivity. We found 44 "heritable DICCCOLs" whose connectivity was genetically influenced (a2>1%); half of them showed significant heritability (a2>20%). Our analysis of genetic influences on WM structural connectivity suggests high heritability for some WM projection patterns, yielding new targets for genome-wide association studies.

Entities:  

Keywords:  DICCCOL; heritability

Year:  2015        PMID： 26413210      PMCID： PMC4578156          DOI： 10.1109/ISBI.2015.7164080

Source DB:  PubMed          Journal:  Proc IEEE Int Symp Biomed Imaging        ISSN： 1945-7928


  19 in total

1.  Genetic influences on brain structure.

Authors:  P M Thompson; T D Cannon; K L Narr; T van Erp; V P Poutanen; M Huttunen; J Lönnqvist; C G Standertskjöld-Nordenstam; J Kaprio; M Khaledy; R Dail; C I Zoumalan; A W Toga
Journal:  Nat Neurosci       Date:  2001-12       Impact factor: 24.884

2.  DICCCOL: dense individualized and common connectivity-based cortical landmarks.

Authors:  Dajiang Zhu; Kaiming Li; Lei Guo; Xi Jiang; Tuo Zhang; Degang Zhang; Hanbo Chen; Fan Deng; Carlos Faraco; Changfeng Jin; Chong-Yaw Wee; Yixuan Yuan; Peili Lv; Yan Yin; Xiaolei Hu; Lian Duan; Xintao Hu; Junwei Han; Lihong Wang; Dinggang Shen; L Stephen Miller; Lingjiang Li; Tianming Liu
Journal:  Cereb Cortex       Date:  2012-04-05       Impact factor: 5.357

3.  Genetic influences on brain asymmetry: a DTI study of 374 twins and siblings.

Authors:  Neda Jahanshad; Agatha D Lee; Marina Barysheva; Katie L McMahon; Greig I de Zubicaray; Nicholas G Martin; Margaret J Wright; Arthur W Toga; Paul M Thompson
Journal:  Neuroimage       Date:  2010-04-27       Impact factor: 6.556

4.  Connectome-scale assessments of structural and functional connectivity in MCI.

Authors:  Dajiang Zhu; Kaiming Li; Douglas P Terry; A Nicholas Puente; Lihong Wang; Dinggang Shen; L Stephen Miller; Tianming Liu
Journal:  Hum Brain Mapp       Date:  2013-09-30       Impact factor: 5.038

Review 5.  Whole-genome analyses of whole-brain data: working within an expanded search space.

Authors:  Sarah E Medland; Neda Jahanshad; Benjamin M Neale; Paul M Thompson
Journal:  Nat Neurosci       Date:  2014-05-27       Impact factor: 24.884

6.  Automatic clustering and population analysis of white matter tracts using maximum density paths.

Authors:  Gautam Prasad; Shantanu H Joshi; Neda Jahanshad; Julio Villalon-Reina; Iman Aganj; Christophe Lenglet; Guillermo Sapiro; Katie L McMahon; Greig I de Zubicaray; Nicholas G Martin; Margaret J Wright; Arthur W Toga; Paul M Thompson
Journal:  Neuroimage       Date:  2014-04-18       Impact factor: 6.556

7.  Genetics of brain fiber architecture and intellectual performance.

Authors:  Ming-Chang Chiang; Marina Barysheva; David W Shattuck; Agatha D Lee; Sarah K Madsen; Christina Avedissian; Andrea D Klunder; Arthur W Toga; Katie L McMahon; Greig I de Zubicaray; Margaret J Wright; Anuj Srivastava; Nikolay Balov; Paul M Thompson
Journal:  J Neurosci       Date:  2009-02-18       Impact factor: 6.167

Review 8.  Fusing DTI and fMRI data: a survey of methods and applications.

Authors:  Dajiang Zhu; Tuo Zhang; Xi Jiang; Xintao Hu; Hanbo Chen; Ning Yang; Jinglei Lv; Junwei Han; Lei Guo; Tianming Liu
Journal:  Neuroimage       Date:  2013-10-05       Impact factor: 6.556

9.  Common genetic variants influence human subcortical brain structures.

Authors:  Derrek P Hibar; Jason L Stein; Miguel E Renteria; Alejandro Arias-Vasquez; Sylvane Desrivières; Neda Jahanshad; Roberto Toro; Katharina Wittfeld; Lucija Abramovic; Micael Andersson; Benjamin S Aribisala; Nicola J Armstrong; Manon Bernard; Marc M Bohlken; Marco P Boks; Janita Bralten; Andrew A Brown; M Mallar Chakravarty; Qiang Chen; Christopher R K Ching; Gabriel Cuellar-Partida; Anouk den Braber; Sudheer Giddaluru; Aaron L Goldman; Oliver Grimm; Tulio Guadalupe; Johanna Hass; Girma Woldehawariat; Avram J Holmes; Martine Hoogman; Deborah Janowitz; Tianye Jia; Sungeun Kim; Marieke Klein; Bernd Kraemer; Phil H Lee; Loes M Olde Loohuis; Michelle Luciano; Christine Macare; Karen A Mather; Manuel Mattheisen; Yuri Milaneschi; Kwangsik Nho; Martina Papmeyer; Adaikalavan Ramasamy; Shannon L Risacher; Roberto Roiz-Santiañez; Emma J Rose; Alireza Salami; Philipp G Sämann; Lianne Schmaal; Andrew J Schork; Jean Shin; Lachlan T Strike; Alexander Teumer; Marjolein M J van Donkelaar; Kristel R van Eijk; Raymond K Walters; Lars T Westlye; Christopher D Whelan; Anderson M Winkler; Marcel P Zwiers; Saud Alhusaini; Lavinia Athanasiu; Stefan Ehrlich; Marina M H Hakobjan; Cecilie B Hartberg; Unn K Haukvik; Angelien J G A M Heister; David Hoehn; Dalia Kasperaviciute; David C M Liewald; Lorna M Lopez; Remco R R Makkinje; Mar Matarin; Marlies A M Naber; D Reese McKay; Margaret Needham; Allison C Nugent; Benno Pütz; Natalie A Royle; Li Shen; Emma Sprooten; Daniah Trabzuni; Saskia S L van der Marel; Kimm J E van Hulzen; Esther Walton; Christiane Wolf; Laura Almasy; David Ames; Sampath Arepalli; Amelia A Assareh; Mark E Bastin; Henry Brodaty; Kazima B Bulayeva; Melanie A Carless; Sven Cichon; Aiden Corvin; Joanne E Curran; Michael Czisch; Greig I de Zubicaray; Allissa Dillman; Ravi Duggirala; Thomas D Dyer; Susanne Erk; Iryna O Fedko; Luigi Ferrucci; Tatiana M Foroud; Peter T Fox; Masaki Fukunaga; J Raphael Gibbs; Harald H H Göring; Robert C Green; Sebastian Guelfi; Narelle K Hansell; Catharina A Hartman; Katrin Hegenscheid; Andreas Heinz; Dena G Hernandez; Dirk J Heslenfeld; Pieter J Hoekstra; Florian Holsboer; Georg Homuth; Jouke-Jan Hottenga; Masashi Ikeda; Clifford R Jack; Mark Jenkinson; Robert Johnson; Ryota Kanai; Maria Keil; Jack W Kent; Peter Kochunov; John B Kwok; Stephen M Lawrie; Xinmin Liu; Dan L Longo; Katie L McMahon; Eva Meisenzahl; Ingrid Melle; Sebastian Mohnke; Grant W Montgomery; Jeanette C Mostert; Thomas W Mühleisen; Michael A Nalls; Thomas E Nichols; Lars G Nilsson; Markus M Nöthen; Kazutaka Ohi; Rene L Olvera; Rocio Perez-Iglesias; G Bruce Pike; Steven G Potkin; Ivar Reinvang; Simone Reppermund; Marcella Rietschel; Nina Romanczuk-Seiferth; Glenn D Rosen; Dan Rujescu; Knut Schnell; Peter R Schofield; Colin Smith; Vidar M Steen; Jessika E Sussmann; Anbupalam Thalamuthu; Arthur W Toga; Bryan J Traynor; Juan Troncoso; Jessica A Turner; Maria C Valdés Hernández; Dennis van 't Ent; Marcel van der Brug; Nic J A van der Wee; Marie-Jose van Tol; Dick J Veltman; Thomas H Wassink; Eric Westman; Ronald H Zielke; Alan B Zonderman; David G Ashbrook; Reinmar Hager; Lu Lu; Francis J McMahon; Derek W Morris; Robert W Williams; Han G Brunner; Randy L Buckner; Jan K Buitelaar; Wiepke Cahn; Vince D Calhoun; Gianpiero L Cavalleri; Benedicto Crespo-Facorro; Anders M Dale; Gareth E Davies; Norman Delanty; Chantal Depondt; Srdjan Djurovic; Wayne C Drevets; Thomas Espeseth; Randy L Gollub; Beng-Choon Ho; Wolfgang Hoffmann; Norbert Hosten; René S Kahn; Stephanie Le Hellard; Andreas Meyer-Lindenberg; Bertram Müller-Myhsok; Matthias Nauck; Lars Nyberg; Massimo Pandolfo; Brenda W J H Penninx; Joshua L Roffman; Sanjay M Sisodiya; Jordan W Smoller; Hans van Bokhoven; Neeltje E M van Haren; Henry Völzke; Henrik Walter; Michael W Weiner; Wei Wen; Tonya White; Ingrid Agartz; Ole A Andreassen; John Blangero; Dorret I Boomsma; Rachel M Brouwer; Dara M Cannon; Mark R Cookson; Eco J C de Geus; Ian J Deary; Gary Donohoe; Guillén Fernández; Simon E Fisher; Clyde Francks; David C Glahn; Hans J Grabe; Oliver Gruber; John Hardy; Ryota Hashimoto; Hilleke E Hulshoff Pol; Erik G Jönsson; Iwona Kloszewska; Simon Lovestone; Venkata S Mattay; Patrizia Mecocci; Colm McDonald; Andrew M McIntosh; Roel A Ophoff; Tomas Paus; Zdenka Pausova; Mina Ryten; Perminder S Sachdev; Andrew J Saykin; Andy Simmons; Andrew Singleton; Hilkka Soininen; Joanna M Wardlaw; Michael E Weale; Daniel R Weinberger; Hieab H H Adams; Lenore J Launer; Stephan Seiler; Reinhold Schmidt; Ganesh Chauhan; Claudia L Satizabal; James T Becker; Lisa Yanek; Sven J van der Lee; Maritza Ebling; Bruce Fischl; W T Longstreth; Douglas Greve; Helena Schmidt; Paul Nyquist; Louis N Vinke; Cornelia M van Duijn; Luting Xue; Bernard Mazoyer; Joshua C Bis; Vilmundur Gudnason; Sudha Seshadri; M Arfan Ikram; Nicholas G Martin; Margaret J Wright; Gunter Schumann; Barbara Franke; Paul M Thompson; Sarah E Medland
Journal:  Nature       Date:  2015-01-21       Impact factor: 49.962

10.  Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group.

Authors:  Neda Jahanshad; Peter V Kochunov; Emma Sprooten; René C Mandl; Thomas E Nichols; Laura Almasy; John Blangero; Rachel M Brouwer; Joanne E Curran; Greig I de Zubicaray; Ravi Duggirala; Peter T Fox; L Elliot Hong; Bennett A Landman; Nicholas G Martin; Katie L McMahon; Sarah E Medland; Braxton D Mitchell; Rene L Olvera; Charles P Peterson; John M Starr; Jessika E Sussmann; Arthur W Toga; Joanna M Wardlaw; Margaret J Wright; Hilleke E Hulshoff Pol; Mark E Bastin; Andrew M McIntosh; Ian J Deary; Paul M Thompson; David C Glahn
Journal:  Neuroimage       Date:  2013-04-28       Impact factor: 6.556
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  2 in total

1.  The heritability of multi-modal connectivity in human brain activity.

Authors:  Giles L Colclough; Stephen M Smith; Thomas E Nichols; Anderson M Winkler; Stamatios N Sotiropoulos; Matthew F Glasser; David C Van Essen; Mark W Woolrich
Journal:  Elife       Date:  2017-07-26       Impact factor: 8.140

2.  Are Sex Differences in Human Brain Structure Associated With Sex Differences in Behavior?

Authors:  Liza van Eijk; Dajiang Zhu; Baptiste Couvy-Duchesne; Lachlan T Strike; Anthony J Lee; Narelle K Hansell; Paul M Thompson; Greig I de Zubicaray; Katie L McMahon; Margaret J Wright; Brendan P Zietsch
Journal:  Psychol Sci       Date:  2021-07-29
  2 in total

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